Pantoprazole 40 mg Tablet (Pantoprazole Sodium Sesquihydrate)

Adult dose

1. Antibiotic combination therapy to prevent recurrence of gastroduodenal ulcers infected with Helicobacter pylori - The usual adult dose is 40 mg of pantoprazole twice daily (before breakfast and the evening meal) for 1 week, in combination with the following antibiotics. Do not chew or crush. (1) Take 1,000 mg of amoxicillin and 500 mg of clarithromycin twice daily for 1 week, or (2) Take 500 mg of metronidazole and 500 mg of clarithromycin twice daily for 1 week, or (3) Take 1,000 mg of amoxicillin and 500 mg of metronidazole twice daily for 1 week. - The metronidazole regimens in (2) and (3) should be used only when regimen (1) is inappropriate. - If additional treatment with pantoprazole is indicated to ensure ulcer healing, the recommended doses according to the regimens below should be considered for duodenal and gastric ulcers. - If combination therapy is not needed (e.g., negative for Helicobacter pylori infection), use pantoprazole monotherapy according to the regimens below. 2. Gastric ulcer and reflux esophagitis - The usual adult dose is 40 mg of pantoprazole once daily, taken with water before breakfast. Do not chew or crush. - Healing occurs within 4 weeks in most patients, although the healing time may vary occasionally. If the ulcer has not healed after the initial 4 weeks of treatment, continue treatment for an additional 4 weeks. - If there has been no response to other treatments, the dose may be doubled (to 80 mg of pantoprazole daily). 3. Duodenal ulcer - The usual adult dose is 40 mg of pantoprazole once daily, taken with water before breakfast. Do not chew or crush. - Healing occurs within 2 weeks in most patients, although the healing time may vary occasionally. If the ulcer has not healed after the initial 2 weeks of treatment, continue treatment for an additional 2 weeks. - If there has been no response to other treatments, the dose may be doubled (to 80 mg of pantoprazole daily). 4. Zollinger-Ellison syndrome and other pathological hypersecretory conditions - Start with an initial dose of 80 mg of pantoprazole daily, then increase or decrease the dose according to gastric acid secretion measurements. - Doses greater than 80 mg should be divided into two daily doses. - A temporary increase to more than 160 mg is possible, but should be used only for as long as needed to achieve adequate acid control. - The duration of treatment is not limited, but should be adjusted according to clinical need. ○ In patients with severe liver impairment, reduce the dose so that it does not exceed 20mg of pantoprazole once daily. ○ In elderly patients or patients with renal impairment, the dose should not exceed 40 mg of pantoprazole daily. As an exception, elderly patients may take 40 mg of this medicine twice daily (before breakfast and the evening meal) for 1 week as part of the antibiotic combination therapy described above. Do not chew or crush. ○ Antibiotic combination therapy should not be used in patients with moderate to severe hepatic/renal impairment. There are insufficient data on the efficacy and safety of this combination therapy.

It is advisable to avoid using this medication in patients with moderately to severely impaired liver or kidney function. Patients with allergies or hypersensitivity to this drug, its components, or benzimidazole drugs should not take it. Care should be taken when combining this medication with penicillin or macrolide antibiotics in patients with known allergies. Women in early pregnancy, those who may become pregnant, and breastfeeding women should avoid using this drug. This medication suppresses gastric acid secretion and may increase the risk of infection due to bacterial overgrowth in the stomach with long-term use. Long-term use may lead to vitamin B12 absorption disorders or electrolyte abnormalities like hypomagnesemia, necessitating regular monitoring. This medication interacts with certain antiviral drugs or antibiotics, which may reduce its efficacy or increase the risk of side effects; therefore, it should be discussed with a healthcare professional. Dizziness or vision disturbances may occur while taking this medication, requiring caution during driving or machinery operation. When taking this medication, it should be swallowed whole, not chewed or crushed, and kept out of reach of children. There is no specific antidote for overdose; appropriate treatment should be provided based on symptoms. The safety and efficacy of this medication have not been sufficiently confirmed in children or adolescents under 18 years of age. Any unusual symptoms or suspected side effects during treatment should prompt immediate consultation with a healthcare professional.

• Upper abdominal pain
• constipation
• bloating
• diarrhea
• gastric polyps
• nausea
• vomiting
• belching
• dry mouth
• fatigue

This medication is sensitive to light and should be stored in a tightly closed container that protects it from light. It is important to maintain the storage temperature between 1°C and 30°C at room temperature.

Appearance

Yellow oval enteric-coated tablet

Package unit

30 tablets/bottle