Itraconazole Capsule (Itraconazole)

Adult dosage

To increase absorption, it is preferable to administer this medicine immediately after a meal. The capsules must be swallowed whole. 1. Short-term treatment This medicine continues to have a therapeutic effect in skin tissue even after discontinuation. Therefore, the final clinical and mycological response should preferably be assessed 2～4 weeks after completing the prescribed course of treatment. 1) Vulvovaginal candidiasis: Administer itraconazole 200 mg twice daily (morning and evening) for 1 day, or 200 mg once daily for 3 days. 2) Pityriasis versicolor: Administer 200 mg once daily for 7 days. 3) Tinea corporis and tinea cruris: Administer 100 mg once daily for 15 days. 4) Tinea manuum (interdigital type) and tinea pedis (interdigital type): Administer 100 mg once daily for 15 days. 5) Tinea manuum (palms) and tinea pedis (soles): Administer 100 mg once daily for 30 days or 200 mg twice daily for 7 days. 6) Oral candidiasis: Administer 100 mg once daily for 15 days. 7) Fungal keratitis: Administer 200 mg once daily for 21 days. 2. Onychomycosis 1) Pulse therapy Administer 200 mg twice daily for 1 week, followed by a 3-week treatment-free period; this constitutes one cycle. Administer up to 2 cycles if only the fingernails are infected and up to 3 cycles if the toenails are infected. Site of onychomycosis Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Toenails (with or without fingernail infection) Treatment Treatment-free Treatment Treatment-free Treatment Fingernails Treatment Treatment-free Treatment 2) Continuous therapy Administer 200 mg once daily for 3 months. The therapeutic effect continues for 3 months for fingernails and 6 months for toenails after completion of treatment. 3. Systemic fungal infections In patients with impaired immune function, such as those with neutropenia, AIDS, or organ transplant recipients, the oral bioavailability of this medicine may be reduced; therefore, if necessary, the dose may be doubled. Aspergillosis: 200mg once daily for 2~5 months. For invasive or disseminated disease, increase to 200mg twice daily. Candidiasis: 100~200mg once daily for 3 weeks~7 months. Cryptococcal meningitis: 200mg twice daily for 2 months~1 year. Maintenance therapy (for AIDS patients only): 200mg once daily2 Paracoccidioidomycosis: 100mg once daily for 6 months. There are no efficacy data for this dosage regimen for the treatment of paracoccidioidomycosis in ADIS patients. 1 The duration of treatment should be adjusted according to clinical response. 2 The duration of treatment should depend on immune recovery.

It is crucial not to use this medication in patients with compromised heart function. Particularly, caution is needed in patients with congestive heart failure or reduced ventricular function as it may pose a life-threatening risk. Patients who have had allergic reactions to this medication or are hypersensitive to its components should avoid its use. Additionally, serious side effects can occur when this drug is taken with certain medications, so it is essential to consult with a physician. Women who are pregnant or potentially pregnant, as well as those who are breastfeeding, should refrain from using this medication as it may affect the fetus and can be transmitted to the baby through breast milk. Patients with liver dysfunction may have difficulty metabolizing this medication and should undergo regular liver function tests, while those with impaired renal function may also need dose adjustments. During treatment, symptoms such as headache, nausea, abdominal pain may occur, and rarely, serious side effects like liver dysfunction, skin rash, and hearing loss can arise, so any such symptoms should be reported to a physician immediately. Moreover, this medication can interact with multiple drugs and may alter the effectiveness or increase the side effects of concomitant medications, so all medications being taken should be informally disclosed to healthcare providers. Lastly, caution should be exercised when administering this medication to children or the elderly, ensuring that the recommended dosage is not exceeded. In cases of overdose, prompt medical attention should be sought.

Headache, nausea, abdominal pain, rhinitis, sinusitis, upper respiratory infection, leukopenia, hypersensitivity, taste disorder, sensory loss, sensory distortion, tinnitus, constipation, diarrhea, dyspepsia, bloating, vomiting, liver dysfunction, hyperbilirubinemia, itching, rash, urticaria, polyuria, erectile dysfunction, menstrual disorders, edema, neutropenia, thrombocytopenia, anaphylactoid reaction, hyperglycemia, hyperkalemia, hypokalemia, hypomagnesemia, altered mental status, peripheral neuropathy, dizziness, drowsiness, tremors, heart failure, left ventricular failure, tachycardia, hypertension, hypotension, pulmonary edema, voice disorder, cough, gastrointestinal disturbance, liver failure, hepatitis, jaundice, erythematous rash, hyperhidrosis, myalgia, arthralgia, renal impairment, urinary incontinence, generalized edema, facial edema, chest pain, fever, pain, fatigue, chills, increased alanine aminotransferase, increased aspartate aminotransferase, elevated serum alkaline phosphatase, increased serum lactate dehydrogenase, increased blood urea, increased gamma-glutamyl transferase, elevated liver enzymes, abnormal urinalysis, leukocytosis, eosinophilia, anemia, vascular edema, serum sickness, angioedema, anaphylaxis, anaphylactic shock, allergic reaction, diplopia, visual impairment, hearing loss, ventricular premature contractions, atrial block, palpitations, increased bowel motility, belching, tongue inflammation, stomatitis, abdominal pain in the lumbar region, pancreatitis, elevated serum total protein, increased total bilirubin, elevated LAP, anorexia, malaise, brown urine, skin mucous membrane syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, Riel syndrome, erythema multiforme, hair loss, photosensitivity reaction, exfoliative dermatitis, leukocytoclastic vasculitis, acute generalized pustular rash, increased BUN, positive urine protein reaction, positive urine glucose reaction, decreased libido, drowsiness, shoulder stiffness, insomnia, chest discomfort, elevated serum triglycerides, burning sensation, elevated serum uric acid, increased serum potassium, serum sickness, angioedema, anaphylactic reaction, hypertriglyceridemia, tremors, visual impairment, transient or permanent hearing loss, congestive heart failure, dyspnea, pancreatitis, serious liver toxicity, toxic epidermal necrolysis, acute generalized pustular rash, erythema multiforme, exfoliative dermatitis, leukocytoclastic vasculitis, hair loss, photosensitivity, increased serum creatine phosphokinase activity

This medication should be stored in a tightly sealed container to prevent air ingress and is best kept at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the drug's efficacy and prevent degradation.

Appearance

A hard capsule with a milky blue upper part and a pink lower part filled with white or yellowish spherical pellets

Package unit

30 capsules/bottle, 100 capsules/bottle