Metirin Tablet (Cimetidine)

Adult dosage

As cimetidine, administer 400 mg orally twice daily (in the morning and at bedtime) or one dose of 800 mg at bedtime. Additionally, administer 300 mg orally four times a day (after meals and at bedtime). The dosage can be increased to 400 mg orally four times daily (after meals and at bedtime) up to a total of 1.6 g. For acute gastritis and acute exacerbations of chronic gastritis, administer 200 mg twice daily or one dose of 400 mg daily.

Children's dosage

Administer 20–40 mg per kg of body weight divided orally per day.

This medication contains the ingredient cimetidine and should not be administered to certain patients. For example, patients who are allergic to this medication or have experienced hypersensitive reactions, as well as those taking dofetilide, should not use this medication as it can significantly increase the risk of serious arrhythmia. Patients with kidney or liver function disorders, a history of drug allergies, the elderly, children under the age of 19, and those undergoing dialysis should use this medication with caution. In particular, patients with kidney impairment may have elevated blood concentrations of this medication, necessitating a reduction in dosage or an increase in the dosing interval, and it is preferable to administer it after dialysis. This medication may mask symptoms of stomach cancer, so it should only be used after stomach cancer has been ruled out. Patients with gastric or duodenal ulcers caused by Helicobacter pylori require treatment to eradicate the bacteria. Additionally, this medication contains colorants Yellow No. 4 and Yellow No. 5, so patients allergic to these components should exercise caution. While taking this medication, rare occurrences of blood cell count reduction, liver dysfunction, kidney problems, hypersensitivity reactions, gynecomastia, dyspepsia, headache, dizziness, mental disorders, cardiac rhythm abnormalities, and severe skin reactions may occur, so patients should consult their physician immediately if any unusual symptoms arise. During treatment, carefully monitor the progression of the illness, and if there is no effect, consider changing to another treatment method. Particularly, in the elderly or patients with chronic diseases, the risk of pneumonia may increase, so caution is advised. This medication has many drug interactions that may affect the efficacy or concentration of other drugs such as anticoagulants, anxiolytics, cardiac medications, and antidepressants; therefore, patients should inform their healthcare provider of any other medications they are taking. Women who are pregnant or may become pregnant should use this medication cautiously, as its safety has not been definitively established; it can cross the placenta and be excreted in breast milk, so it should be avoided during breastfeeding or the nursing period should be halted. For children, safety has not been established and should only be used when absolutely necessary; in the elderly, dosage adjustments may be needed due to decreased kidney function that can lead to increased drug concentrations. In case of overdose, serious symptoms such as respiratory depression may occur, requiring immediate emergency treatment, and this medication should be kept out of the reach of children. Finally, this medication is best kept in its original container to maintain quality.

Serious side effects

Systemic malaise, weakness, subcutaneous hemorrhage, mucosal bleeding, fever (initial symptom of blood system disorders), jaundice, fever (initial symptom of renal dysfunction), shock, anaphylaxis-like reactions (generalized rash, difficulty breathing), seizures, altered consciousness, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), epidermal necrosis, polymorphic erythema, generalized exfoliative erythema, respiratory depression with cyanosis of the lips, convulsions, respiratory difficulty, cardiac.

Mild side effects

• Leukopenia
• granulocytopenia
• agranulocytosis
• thrombocytopenia
• pancytopenia
• aplastic anemia
• immune hemolytic anemia
• hepatitis
• elevated AST and ALT
• liver fibrosis

This medication should be stored in a well-sealed container that is airtight, and it is important to maintain storage temperatures between 1 and 30 degrees Celsius at room temperature. Proper storage will help preserve the drug's effectiveness and prevent deterioration.

Appearance

Light green round film-coated tablet

Package unit

500 tablets/bottle