Samsetil Tablets (Cefuroxime Axetil)

Adult dose

For optimal absorption, take after meals. Adults and children aged 12 years or older Most infections: Administer 250mg per dose twice daily. Severe lower respiratory tract infections, pneumonia, severe infections, or infections suspected to be caused by organisms with low susceptibility: Administer 500mg per dose twice daily. Urinary tract infections: Administer 250mg per dose twice daily. Uncomplicated gonorrhea: Administer 1g as a single dose. Lyme disease: Administer 500mg per dose twice daily for 14 days (10~21 days). Patients with renal impairment ≥ 30 mL/min/1.73m2: No dosage adjustment required (standard dose: 125mg-500mg per dose twice daily) 10 - 29 mL/min/1.73m2: Administer the standard single dose every 24 hours < 10 mL/min/1.73m2: Administer the standard single dose every 48 hours Patients undergoing hemodialysis: Administer an additional standard single dose at the end of each dialysis session

Child dose

Infants and children under 12 years of age, most infections: Administer 125mg per dose twice daily. Children aged 2 years or older with otitis media or severe infections: Administer 250mg per dose twice daily. Infants and children under 12 years of age, Lyme disease: Administer 250mg per dose twice daily for 14 days (10~21 days). Infants under 3 months of age: There is insufficient experience with use. For the treatment of infections caused by Streptococcus pyogenes (Group A beta-hemolytic), this medicine should be administered for 7~10 days. This medicine must not be divided and is therefore not suitable for patients who cannot swallow tablets, such as young infants and children.

This medication is a cephalosporin antibiotic and should not be administered to patients with a known allergy to this class of drugs. Caution should be taken for patients with a history of allergy to penicillin or other beta-lactam antibiotics, those with a familial history or who are predisposed to allergies. Patients with severely impaired renal function, those who cannot take it orally, the elderly, and those in poor systemic condition should also be monitored closely. While using this drug, excessive proliferation of Candida or resistant bacteria in the intestines may occur, thus monitoring is necessary. If gastrointestinal symptoms such as diarrhea or abdominal pain occur, consider the possibility of pseudomembranous colitis and discontinue treatment immediately. Serious skin reactions can occur, so monitor the skin condition and stop use immediately if any abnormal symptoms arise. Caution is advised while driving or operating machinery, as dizziness may occur. This drug may interact with other medications, especially diuretics, certain antibiotics, and antacids, which can affect renal function or drug efficacy, so consulting a specialist is advised. Use during pregnancy or nursing should be decided with caution, particularly considering risks and benefits during early pregnancy. It is not established as safe for infants under 3 months old, and for children, it is advisable to select an appropriate formulation due to potential difficulties with taste. Elderly patients may experience more side effects due to declining physical function, so dosages and intervals should be adjusted and monitored closely. This medication can affect the results of blood tests, so inform healthcare professionals about its usage during testing. In cases of overdose, seizures may occur; seek medical attention immediately for appropriate treatment. Finally, this medication should be kept out of the reach of children and stored in its original container to maintain quality.

• Candida overgrowth
• eosinophilia
• positive Coombs test
• thrombocytopenia
• leukopenia
• granulocytopenia
• anemia
• decreased hemoglobin
• decreased hematocrit
• hemolytic anemia

Store this medication in a sealed container to prevent exposure to air and moisture, and keep it in a cool place below 30 degrees Celsius. Storing it this way will help maintain its effectiveness for a longer period.

Appearance

White to off-white, oval film-coated tablet

Package unit

100 tablets/box [(10 tablets/PTP×10)]