Megafebokjeong 80 Milligrams (Febuxostat)

Adult dosage

1. Adults This medicine is administered at a dose of 40mg or 80mg once daily, regardless of meals. As this medicine acts very rapidly, recheck the serum uric acid concentration after 2 weeks. The treatment goal is to lower and maintain the serum uric acid concentration below 6 mg/dL(357 μmol/L). 2. Patients with renal impairment No dosage adjustment is necessary in patients with mild or moderate renal impairment. The safety and efficacy of this medicine have not been adequately evaluated in patients with severe renal impairment (creatinine clearance less than 30mL/min). 3. Patients with hepatic impairment No special dosage adjustment is necessary in patients with mild or moderate hepatic impairment. Limited information is available for patients with moderate hepatic impairment, and the efficacy and safety of this medicine have not been studied in patients with severe hepatic impairment (Child Pugh class C).

This drug may increase the risk of cardiovascular death when administered to patients with cardiovascular diseases, so caution should be exercised when using in patients with a history of cardiovascular diseases. Patients with hypersensitivity to the components of this drug or those taking certain medications (mercaptopurine, azathioprine), along with patients with specific genetic diseases such as lactose intolerance, should not use this drug. Patients with a history of liver disease or thyroid dysfunction, and those with heart failure should have regular liver function tests and thyroid function tests conducted when administering this medication. This drug may cause side effects such as liver dysfunction, diarrhea, headache, rash, fatigue, dizziness, and if symptoms of liver dysfunction occur, administration should be stopped immediately, and tests should be conducted. When acute gout attacks are present, this medication should not be initiated, and it should not be discontinued during a gout attack but rather managed appropriately. If cardiovascular symptoms or adverse reactions occur, it is important to inform medical personnel immediately and to monitor carefully. This drug may cause symptoms like drowsiness and dizziness, so caution should be taken when driving or operating dangerous machinery. There may be interactions with certain medications, so if you are taking other medications, you must inform medical personnel, especially to avoid co-administration with mercaptopurine and azathioprine. Women who are pregnant or breastfeeding are advised not to take this medication. There is no experience in using this medication in children under 18 years, so it should not be administered. There is no need for special dosage adjustments for the elderly, although caution is needed. While there are no specific cases reported for overdose, appropriate treatment should be administered based on symptoms. This drug should be kept out of reach of children, and special storage conditions are not required.

Liver dysfunction, dizziness, diarrhea, headache, rash, nausea, fatigue, arthralgia, limb pain, gout, myalgia, pruritus, respiratory distress, anemia, idiopathic thrombocytopenic purpura, leukocytosis, leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia, angina, atrial fibrillation, atrial flutter, heart murmur, abnormal electrocardiogram, palpitations, bradycardia, tachycardia, hearing loss, tinnitus, vertigo, blurred vision, abdominal distension, abdominal pain, constipation, dry mouth, dyspepsia, flatulence, increased bowel frequency, gastritis, gastroesophageal reflux disease, gastrointestinal discomfort, gum pain, hematemesis, excessive hydrochloric acid, passage of blood in stools, oral ulcer, pancreatitis, gastric ulcer, vomiting, weakness, chest pain, chest discomfort, edema, emotional disturbances, walking difficulties, influenza-like symptoms, pain, thirst, cholelithiasis, diabetes mellitus, fatty liver, hepatitis, hepatomegaly, hypersensitivity, herpes zoster, anorexia, decreased appetite, increased appetite, dehydration, diabetes, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, hypokalemia, weight loss, weight gain, arthritis, joint stiffness, joint swelling, muscle cramping, muscle single contraction, muscle tightness, muscle weakness, musculoskeletal pain, muscle rigidity, taste changes, balance disturbances, cerebrovascular accident, Guillain-Barré syndrome, headache, partial motor paralysis, sensory deficit, olfactory decrease, heat stroke, drowsiness, mental disorders, migraine, sensory abnormalities, sleepiness, transient ischemic attack, tremors, restlessness, anxiety, depression, insomnia, excitability, decreased libido, neuroirritability, panic attacks, personality changes, hematuria, nephrolithiasis, increased urinary frequency, proteinuria, renal failure, renal insufficiency, urinary urgency, urinary incontinence, breast pain, erectile dysfunction, gynecomastia, bronchitis, cough, respiratory distress, nosebleed, nasal dryness, sinus hypersecretion, pharyngeal edema, airway congestion, sneezing, throat irritation, upper respiratory infection, alopecia, angioedema, dermatitis, skin rash, petechiae, eczema, hair discoloration, abnormal hair growth, hyperhidrosis, skin peeling, petechial hemorrhages, photosensitivity, itching, purpura, skin discoloration, pigmentation changes, skin lesions, axillary hyperhidrosis, urticaria, flushing, facial flushing, hypertension, hypotension, activated partial thromboplastin time prolongation, creatinine elevation, bicarbonate decrease, sodium increase, EEG abnormalities, glucose elevation, cholesterol elevation, triglycerides elevation, amylase elevation, potassium elevation, thyroid-stimulating hormone elevation, thrombocyte decrease, hematocrit decrease, hemoglobin decrease, MCV increase, erythrocyte decrease, creatinine increase, blood urea elevation, blood urea to creatinine ratio increase, CPK elevation, ALP elevation, LDH elevation, PSA elevation, increased urine output, decreased urine output, lymphocyte count decrease, neutrophil count decrease, leukocyte count increase, leukocyte count decrease, abnormal blood coagulation tests, low-density lipoprotein elevation, prothrombin time prolongation, urinary casts, positive urinary white blood cells, positive urinary protein, bruising, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute anaphylactic reaction, shock, severe allergic reaction, hypersensitivity reactions, eosinophilia, systemic symptoms, fever, hematological disorders, renal disorders, liver disorders, liver failure, jaundice, hepatic impairment, agranulocytosis, rhabdomyolysis

This medication should be stored in a tightly closed container to protect it from air or moisture and is best kept at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the effectiveness of the medication for a longer time.

Appearance

Pale yellow to yellow oblong film-coated tablet

Package unit

30 tablets / bottle, 100 tablets / bottle