Invega Extended-Release Tablet 3mg (Paliperidone)

Adult dose

Schizophrenia, adults (18 years and older): This medicine is administered orally as paliperidone 6mg once daily in the morning. Administer this medicine consistently either with food or on an empty stomach; do not alternate between the two. No initial dose adjustment is necessary. Some patients may benefit from a lower or higher dose within the range of 3-12mg of paliperidone once daily. Dose adjustments should be made only after clinical reassessment. If dose escalation is needed, it is recommended to increase the dose by 3mg per day at intervals of at least 5 days. Schizoaffective disorder, adults (18 years and older): This medicine is administered orally as paliperidone 6mg once daily in the morning. Administer this medicine consistently either with food or on an empty stomach; do not alternate between the two. No initial dose adjustment is necessary. Some patients may benefit from a lower or higher dose within the range of 3-12mg of paliperidone once daily. Dose adjustments should be made only after clinical reassessment. If dose escalation is needed, it is recommended to increase the dose by 3mg per day at intervals of at least 4 days. This medicine should be swallowed whole with liquid and must not be chewed, cut, or crushed. Patients with hepatic impairment: No dose adjustment is necessary in patients with mild or moderate hepatic impairment (Child-Pugh Classification A and B). This medicine has not been studied in patients with severe hepatic impairment. Patients with renal impairment: Dosing should be individualized according to the patient's renal function. Patients with mild renal impairment (creatinine clearance of 50ml/min or more and less than 80ml/min): The recommended initial dose is 3mg once daily. Following clinical reassessment, the dose may be increased up to a maximum of 6mg per day. Patients with moderate or severe renal impairment (creatinine clearance of 10ml/min or more and less than 50ml/min): The recommended initial dose is 1.5mg once daily. Following clinical reassessment, the dose may be increased up to a maximum of 3mg per day. This medicine has not been studied in patients with creatinine clearance below 10ml/min; therefore, administration of this medicine to these patients is not recommended. Older adults: Renal function may be decreased in older adults, and dose adjustment may be needed based on renal function. In general, the recommended dose for older adults with normal renal function is the same as that for adults with normal renal function. In patients with moderate or severe renal impairment (creatinine clearance of 10ml/min or more and less than 50ml/min), the maximum recommended dose of this medicine is 3mg once daily.

Child dose

Adolescents (12-17 years): This medicine is administered orally as paliperidone 3mg once daily in the morning. Administer this medicine consistently either with food or on an empty stomach; do not alternate between the two. No initial dose adjustment is necessary. Some patients may benefit from a higher dose within the range of 6-12mg of paliperidone once daily. Dose adjustments should be made only after clinical reassessment. If dose escalation is needed, the dose should be increased by 3mg per day at intervals of at least 5 days. High doses in clinical trials in adolescents with schizophrenia: less than 51kg: 6mg; 51kg or more: 12mg

Caution is advised as this medication may increase the risk of death when used in elderly patients with dementia-related psychosis. Before taking this medication, assess the risk factors for venous thromboembolism and take necessary preventive measures. Do not take this medication if you are allergic to it or any of its components, or if you have certain gastrointestinal diseases or swallowing difficulties. Women who are breastfeeding should not take this medication. Patients with cardiovascular disease or cerebrovascular disease, hypotension, epilepsy, or severely impaired kidney or liver function should use this medication with caution. Patients with diabetes or temperature regulation issues, or patients with Parkinson's disease or certain types of dementia also require caution. This medication can cause various side effects such as drowsiness, dizziness, cardiac irregularities, gastrointestinal discomfort, and weight changes, and patients should consult healthcare providers if symptoms occur. Particularly, watch carefully for cardiac-related side effects and neurological symptoms. Women who are pregnant or planning to become pregnant should consult with a doctor before taking this medication as it may affect the fetus. This medication is also not recommended for women who are breastfeeding. This medication may interact with other drugs, so be sure to inform your healthcare provider of any other medications you are taking. It may cause QT interval prolongation; therefore, patients with a history of heart disease or those at risk for QT prolongation need careful evaluation before taking this medication. In case of overdose, seek medical assistance immediately for appropriate treatment, and keep this medication out of reach of children. It is advisable to avoid activities requiring alertness, such as driving or operating machinery, while taking this medication.

Increased mortality, heart failure, sudden death, pneumonia, venous thrombosis, first-degree atrioventricular block, bradycardia, bundle branch block, palpitations, arrhythmia, tachycardia, rapid heartbeat, dry eyes, eye movement, blurred vision, abdominal pain, upper abdominal pain, diarrhea, dry mouth, dyspepsia, nausea, hypersalivation, gastric discomfort, toothache, vomiting, weakness, fatigue, fever, bronchitis, nasopharyngitis, rhinitis, upper respiratory infection, viral infection, falls, increase in alanine aminotransferase, increase in blood creatine phosphokinase, increase in blood insulin, increase in blood pressure, increase in blood triglycerides, prolonged QT interval on electrocardiogram, T wave abnormalities on electrocardiogram, T wave inversion on electrocardiogram, abnormal electrocardiogram, increased heart rate, increase in insulin C-peptide, weight loss, weight gain, decreased appetite, increased appetite, arthralgia, lumbago, muscle rigidity, neck pain, severe pain, shoulder pain, inability to sit still, dizziness, movement disorders, dystonia, extrapyramidal disorders, headache, excessive tension, Parkinsonism, sedation, drowsiness, syncope, tremor, aggression, anxiety, depression, nightmares, suicidal thoughts, cough, nasal congestion, pruritus, hypotension, orthostatic hypotension, agranulocytosis, thrombocytopenia, inappropriate secretion of antidiuretic hormone, diabetes mellitus, diabetic ketoacidosis, hypoglycemia, water intoxication, tension syndrome, mania, sleepwalking, sleep-related eating disorder, taste disturbance, delayed movement disorders, intraoperative iris tension reduction syndrome, atrial fibrillation, deep vein thrombosis, pulmonary embolism, sleep apnea syndrome, pancreatitis, intestinal obstruction, jaundice, angioedema, hair loss, drug reactions associated with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, toxic epidermal necrolysis, urinary retention, incontinence, neonatal drug withdrawal symptoms, priapism, hypothermia, anaphylaxis, edema, nightmares, position-related dizziness, generalized tonic-clonic seizure, hypersomnolence, syncope, amenorrhea, galactorrhea, mastitis, breast pain, erectile dysfunction, excessive lactation, gynecomastia, irregular menstruation, ischemia, chest pain, bradykinesia, sensory loss, breastfeeding difficulties, tinea pedis, flushing, myalgia, speech disorder, oropharyngeal pain, throat pain, vascular disorders, hypertension, weight gain, weight gain, weight loss, increased appetite, decreased appetite, myalgia, speech disorder, oropharyngeal pain, throat pain, vascular disorders, hypertension, weight gain, weight gain, weight loss, increased appetite, decreased appetite, myalgia, speech disorder, oropharyngeal pain, throat pain, vascular disorders, hypertension, weight gain, weight gain, weight loss, increased appetite, decreased appetite, myalgia, speech disorder, oropharyngeal pain, throat pain, vascular disorders, hypertension, weight gain, 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appetite, myalgia, speech disorder, oropharyngeal pain, throat pain, vascular disorders

Store this medication in a tightly sealed container that does not allow air to enter, maintaining a temperature between 15 and 30 degrees Celsius. Also, take care to store the medication away from moisture.

Appearance

White capsule-shaped extended-release film-coated tablets

Package unit

30 tablets/bottle