Yuhan Metformin Hydrochloride Tablet 500 mg

Adult dosage

The dosage should be determined based on individual drug efficacy and tolerability. Administer 500 mg 2 to 3 times daily with meals. Increase the dosage gradually by 500 mg weekly, and when dosed up to 2000 mg, it is generally split into two doses in the morning and evening. If exceeding 2000 mg, administer in three doses with meals, with a maximum of 2550 mg possible. Monitor blood glucose before starting treatment.

Children's dosage

Can be used in children and adolescents aged 10 and older. The typical starting dose is 500 mg once daily taken with or after meals. Assess blood sugar after one week to adjust the dosage. The maximum daily dose is 2000 mg.

This medication can cause severe lactic acidosis or hypoglycemia, so caution is needed. It should not be administered to patients with moderately decreased renal function, those in a state of dehydration, or patients with serious infections, cardiovascular collapse, acute myocardial infarction, sepsis, or other acute conditions. Patients with acute and unstable heart failure or those receiving intravenous iodinated contrast material should also refrain from using this medication. It is contraindicated in patients with a hypersensitivity to this drug or other biguanides, type 1 diabetes patients, and those with a history of lactic acidosis or ketoacidosis. Patients with severe infections or severe traumatic systemic disorders should temporarily stop this medication until recovery and normal renal function are established. In surgical cases, it should be discontinued 48 hours prior to surgery and resumed only after confirming normal renal function. Patients with malnutrition, starvation, debility, pituitary or adrenal insufficiency, liver dysfunction or mesenteric infarction, severe respiratory dysfunction, excessive alcohol consumption, dehydration, or gastrointestinal disorders should be cautious. It is advisable not to use this medication in pregnant women with placental dysfunction, preeclampsia, or risk of intrauterine growth retardation. This drug should be administered cautiously to patients with irregular meals, insufficient food intake, those engaging in vigorous exercise, or those taking interacting medications. Lactic acidosis is a rare but serious side effect, with early symptoms appearing as fatigue, muscle pain, shortness of breath, weakness, and abdominal pain, necessitating immediate notification to medical personnel if symptoms arise. Gastrointestinal symptoms such as diarrhea, nausea, vomiting, abdominal bloating, and loss of appetite are common and can often be mitigated initially through dosage adjustments or taking with meals. The drug is excreted through the kidneys, so regular monitoring of renal function is necessary, and in cases of decreased renal function, dosage should be reduced or administration should be ceased. The risk of hypoglycemia is low when taken alone, but caution is advised when taken with other hypoglycemic agents or alcohol. Since it can cross the placenta during pregnancy, women who are pregnant or planning to become pregnant should consult healthcare providers regarding the use of this medication. During lactation, since it may be secreted in breast milk, breastfeeding is not recommended, and decisions should be made regarding either stopping breastfeeding or discontinuing the medication in consideration of potential risks to the infant. Elderly patients may have impaired renal function, necessitating proper dosage adjustments and regular monitoring of renal function. There are interactions with this medication and other drugs, so patients must inform medical personnel of any medications being taken, and blood glucose changes and patient conditions should be closely monitored. In case of overdose, blood dialysis may be required, so immediate medical attention should be sought if an overdose is suspected. Regular blood glucose testing and renal function monitoring during the course of this medication are essential for safe treatment.

Serious side effects

Lactic acidosis, death due to severe lactic acidosis, acute deterioration of renal function, hypoglycemia, severe allergic reactions (such as rash), liver abnormalities (liver function abnormalities), severe edema, hypotension, resistant bradyarrhythmias, serious neurological symptoms (such as headache, altered consciousness), respiratory issues (such as shortness of breath, hyperventilation), renal impairment, acute renal failure, elevated blood pressure, heart failure, sepsis, myocardial infarction, hypoxia, dehydration, severe edema, or urination issues.

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal bloating, loss of appetite, indigestion, constipation, abdominal pain), metallic taste, rash, anemia, leukopenia, thrombocytopenia, vitamin B12 deficiency, liver function abnormalities, hypoglycemia

This medication should be stored in a tightly sealed container to protect it from air and moisture, and it is safe to keep at a temperature between 1 degree and 30 degrees Celsius. This storage helps maintain the drug's efficacy and prevent degradation.

Appearance

White round film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle