Ceftriaxone Sodium Hydrate 1g

Adult administration

Ceftriaxone as a single intravenous or intramuscular injection of 1-2g (amount) once daily. In cases of severe infection or infections caused by moderately susceptible pathogens, the dose may be increased up to 4g (amount) once daily. For the treatment of gonorrhea, a single intramuscular injection of 250mg (amount) is recommended. For the prevention of infection before and after surgery, administer 1-2g (amount) once 30-90 minutes before the surgery.

Child administration

For newborns (up to 14 days old), administer 20-50mg (amount) per kg of body weight once daily, not exceeding 50mg (amount). For infants and children (15 days to 12 years old), administer 20

This medication must not be mixed or administered simultaneously with calcium-containing solutions or other medications. Especially in newborns, mixing this medication with calcium can cause serious problems due to the formation of precipitates in the body; thus, it should never be used. Patients with allergies to this medication or those who have had hypersensitivity reactions to cephalosporins or penicillin antibiotics must not take this drug. Additionally, premature infants and newborns with jaundice or problems with bilirubin binding must not use this medication. Caution is required for individuals with a history of drug allergies or allergic constitutions, patients with severely compromised kidney function, elderly individuals, and patients in poor overall health; dose adjustments or interval modifications may be necessary. Side effects such as diarrhea, rash, urticaria, liver function abnormalities, and blood dyscrasias may occur, and if any abnormal symptoms are present, the physician should be consulted immediately. Rarely, serious allergic reactions or severe side effects such as encephalopathy and worsening kidney function may occur; thus, patient status should be closely monitored during administration. This medication may interact with other drugs, so care must be taken when used with diuretics, aminoglycoside antibiotics, calcium-containing solutions, vitamin K antagonists, etc. Patients must inform healthcare providers of any medications they are currently taking before administration. Women who are pregnant or breastfeeding should use this medication only when the benefits outweigh the risks, as its safety has not been fully established. This medication is not safe for newborns or premature infants due to the risk of bilirubin encephalopathy, and caution should be taken for elderly patients as they have a higher likelihood of adverse effects due to diminished physiological function. During administration, pain at the injection site, phlebitis, nausea, and vomiting may occur; thus, the injection method and speed should be adjusted, and regular tests of liver and kidney function and blood tests should be conducted to monitor for abnormalities. If diarrhea or abdominal pain worsens during use, administration should be discontinued immediately and healthcare providers consulted, as there is a risk of Clostridium difficile-associated colitis following antibiotic treatment. Finally, this medication may cause dizziness when driving or operating machinery, so caution is necessary.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, pallor, severe rash with high fever, blistering, peeling skin, pain in mucous membranes of mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough+fever, jaundice (yellowing of skin or eyes), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, numbness, and urine retention.

Mild side effects

• Eosinophilia
• leukopenia
• thrombocytopenia
• diarrhea
• rash
• increased liver enzymes
• headache
• dizziness
• bronchospasm
• loose stools

This medication should be stored in a sealed container to prevent exposure to air or moisture, and the storage temperature should be maintained between 1 and 30 degrees Celsius. Storing it this way ensures that the medication's efficacy is safely preserved.

Appearance

A colorless, transparent vial filled with white to pale yellow crystalline powder

Package unit

10 vials/box