WiseTNAferi Injection

Adult administration

Dosage and infusion speed are determined based on fat removal and glucose metabolism capacity, and the dosage and bag size are adjusted according to the patient's condition and nutritional needs. - Patients with normal nutritional status or mild metabolic stress: Amino acids at 0.7 to 1.0 g/kg (0.10 to 0.15 g nitrogen/kg) per day. - Patients with moderate to severe metabolic stress: Amino acids at 1.0 to 2.0 g/kg (0.15 to 0.30 g nitrogen/kg) per day via drip infusion.

This drug must be used strictly according to a physician's instructions. If any symptoms of anaphylactic reaction such as fever, chills, rash, or difficulty breathing occur during use, administration must be stopped immediately. This drug may cause precipitation in the blood if used in conjunction with ceftriaxone; therefore, these two medications should not be administered through the same infusion apparatus. If the same infusion line must be used, it should be thoroughly cleaned before and after administration. Caution is especially necessary for premature or low-birth-weight infants as the lipid components of this drug may not be excreted properly in their bodies, leading to risks. Patients allergic to egg or soybean protein, patients with severely impaired liver function, and patients with severe blood coagulation disorders should not use this drug. Additionally, it should not be administered to newborns or children under 2 years of age. Patients with impaired kidney or liver function, patients with fat metabolism issues should be particularly cautious when using this drug and should frequently check blood lipid levels and electrolyte status during administration. Side effects such as fever, nausea, vomiting, thrombophlebitis may occur during administration, and rarely serious allergic reactions or blood pressure changes may occur. This drug is administered intravenously slowly, and the patient's condition should be closely monitored during the initial administration. If there is an electrolyte imbalance, it should be corrected before administration. Long-term use may lead to deficiency of trace elements, thus appropriate supplementation is necessary. Additionally, caution should be taken to not administer simultaneously with blood. Safety has not been established for pregnant or lactating women, and it should only be used when the therapeutic benefits outweigh the risks. Elderly patients may have decreased bodily functions, therefore it is recommended to slow administration speed and adjust dosage accordingly. Performing blood tests 5-6 hours after administration may help obtain accurate test results. In cases of overdose, symptoms such as nausea, vomiting, fluid retention, electrolyte imbalance may occur, and if these symptoms appear, administration should be stopped or the speed should be reduced, and blood dialysis and other measures should be taken if necessary. This drug should not be used if the packaging is damaged or not transparent, and any remaining solution after mixing the components should be discarded. Storage should be done in a sealed container to protect from air or moisture at temperatures between 0-25 degrees Celsius. Freezing should be avoided to maintain the drug's efficacy.

Serious side effects

Hives, anaphylactic reaction (rash, difficulty breathing), severe allergic reaction, respiratory symptoms including hyperventilation, coma, severe edema, high fever.

Mild side effects

• Fever
• chills
• nausea
• vomiting
• temporary increase in liver enzymes
• thrombophlebitis
• hypertension/hypotension
• hemolysis
• reticulocytosis
• abdominal pain

This drug should be stored in a sealed container to protect it from air and moisture. A cool place with a storage temperature between 0 and 25 degrees Celsius is suitable. This will help maintain the drug's efficacy for a long time.

Appearance

This drug consists of an intravenous plastic container divided into three chambers with an oxygen absorber in between. Each inner chamber contains a dextrose solution, amino acids, and electrolytes.

Package unit

Infusion - 360 milliliters/bag, Infusion - 480 milliliters/bag, Infusion - 560 milliliters/bag, Infusion - 960 milliliters/bag, Infusion - 1440 milliliters/bag, Infusion - 1680 milliliters/bag, Infusion - 1920 milliliters/bag