Clavibo Tablets (Clarithromycin)

Adult dosage

Adults: The usual dose is 250mg (potency) of clarithromycin twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7～14 days. In patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or 250mg (potency) twice daily for severe infections. Do not administer this medicine to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily for 14 days in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

Children 12 years and older: Same as adults Children under 12 years: Use clarithromycin dry syrup.

This medicine should not be administered to certain patients. For example, patients allergic to the ingredients in this product or those taking certain antibiotics or heart-related medications may be at risk if they use this product. Patients with severe liver or kidney dysfunction, those who are pregnant or breastfeeding, and those with central nervous system infections should avoid this medication. Additionally, caution is required for patients with irregular heartbeat or a history of prolonged QT interval. Since this drug is mainly excreted by the liver, dosage adjustments are necessary for patients with liver impairment or moderate to severe kidney dysfunction. Caution is also needed for elderly patients, those taking other antibiotics, and patients with a history of specific allergies. This medication can cause various side effects, and while rare, serious allergic reactions, skin rashes, liver dysfunction, kidney issues, and cardiac arrhythmias may occur. Gastrointestinal side effects such as diarrhea and abdominal pain may be common, and in severe cases, serious conditions like pseudomembranous colitis may occur, necessitating vigilance. During the administration of this drug, regular blood tests and liver and kidney function tests should be conducted to detect abnormal signs early and manage them accordingly. Furthermore, this medication has a high potential for drug interactions; therefore, patients taking other medications must consult a doctor or pharmacist. Particularly, caution is needed when used in conjunction with heart-related medications, drugs that affect liver metabolism, hypoglycemic agents, anticoagulants, certain antiviral agents, etc. Pregnant or breastfeeding women should avoid this medication, and if it must be used, breastfeeding should be stopped under the guidance of a professional. For children under the age of 12, careful consideration is needed as the safety and efficacy have not been sufficiently proven. In case of overdose, gastrointestinal symptoms may appear, and prompt medical attention is required. Lastly, patients taking this medication should be cautious during driving or operating machinery due to possible symptoms of dizziness or confusion.

Shock, anaphylactic symptoms, respiratory distress, convulsions, erythema, rash, itching, hives, skin reddening, angioedema, joint swelling, drug rash, abdominal bloating, nausea, vomiting, dyspepsia, abdominal pain, malaise, gas retention, diarrhea, oral mucosal erosion, epigastric pain, thirst, tooth discoloration, pancreatitis, increased amylase, dysgeusia, anorexia, constipation, discoloration of stools, pseudomembranous colitis, hemorrhagic colitis, fever, cough, respiratory distress, abnormal chest X-ray, eosinophilia, eosinophilic pulmonary infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash with eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, increased LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, increased BUN, interstitial nephritis, kidney failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, dysgeusia, hearing loss, paraesthesia, arthralgia, myalgia, hyposmia, tinnitus, auditory impairment, hypoglycemia, tinnitus, hearing impairment, vomiting, nausea, abdominal pain, purpuric rash, acute pancreatitis, increased amylase, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactic reaction, vascular edema, anorexia, decreased appetite, insomnia, anxiety, neurosensitivity, noise sensitivity, psychotic disorders, confusion state, depersonalization, depression, disorientation, hallucinations, abnormal dreams, mania, dysgeusia, headache, loss of consciousness, movement disorders, non-vestibular dizziness, drowsiness, tremor, convulsions, loss of taste, dysosmia, loss of smell, vestibular dizziness, auditory disorders, hearing impairment, cardiac arrest, atrial fibrillation, QT interval prolongation on ECG, ectopic beats, palpitations, vasodilation, asthma, nasal bleeding, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, abnormal liver function tests, cholestasis, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyltransferase, liver failure, hepatocellular jaundice, rash, hyperhidrosis, vesicular dermatitis, papular rash, acne, Henoch-Schonlein purpura, acute generalized pustular psoriasis, muscle cramps, musculoskeletal rigidity, myopathy, elevated serum creatinine, elevated blood urea, nephritis, intravenous site phlebitis, pain at the injection site, inflammation at the injection site, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased International Normalized Ratio, prolonged prothrombin time, abnormal urine color

This medication is sensitive to light; therefore, it should be stored away from direct sunlight. Additionally, it should be stored at room temperature between 1°C and 30°C, and it is important to keep it in an airtight container.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle