I-Clary Tablet 500mg (Clarithromycin)

Adult dosage

Adults: The usual dose of clarithromycin is 250mg (potency) twice daily; for severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7～14 days. In patients with renal failure and creatinine clearance of 30mL/min or less, the dose should be reduced by half. That is, administer 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer this drug to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this drug twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. Helicobacter pylori eradication in patients with duodenal ulcers: For 14 days, administer 500mg (potency) of this drug three times daily in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose three times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

Children 12 years of age and older: Same as adults. Children under 12 years of age: Use clarithromycin dry syrup.

This medication should not be administered to certain patients. First, it is contraindicated for patients allergic to the excipients or macrolide antibiotics in this preparation. Patients with abnormal heart rhythms or severely impaired liver or kidney function should also not receive this drug. Furthermore, it should not be used in patients taking certain heart-related medications, some analgesics, and antibiotics, as well as in women who are pregnant or breastfeeding. Caution is required when administering this medication to patients with impaired liver or kidney function, heart disease, the elderly, and those on other antibiotics. Individuals with a history of allergic reactions or sensitivity to the dyes contained in this medication should also exercise caution. This drug can sometimes cause various side effects such as severe allergic reactions, skin rashes, gastrointestinal issues, respiratory disorders, blood abnormalities, and neurological symptoms. If any unusual symptoms appear while taking this medication, consult a doctor immediately. Additionally, this medication has a high potential for drug interactions, so caution is necessary when given concurrently with other drugs. Consultation with a healthcare professional is advised, especially when taken with heart-related medications, anticoagulants, some sedatives, antifungals, and HIV treatments. Pregnant or breastfeeding women should not use this medication, and children or the elderly should follow professional guidance before administration. In case of overdose, gastrointestinal disturbances or serious neurological symptoms may occur, so the dosage must be strictly adhered to. Lastly, this medication should not be refrigerated and should be stored at room temperature away from direct sunlight.

Shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, itching, urticaria, skin flushing, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, gas retention, diarrhea, oral mucosal erosion, epigastric pain, convulsive form, thirst, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, decreased appetite, constipation, discoloration of stool, pseudomembranous colitis, hemorrhagic colitis, hematochezia, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, taste loss, smell loss, anxiety, insomnia, nightmares, tinnitus, confusion, orientation disturbance, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, hepatic failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, decreased appetite, jaundice, dark urine, pruritus, abdominal tenderness, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, weakness, elevated CPK, elevated myoglobin in blood, elevated myoglobin in urine, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, taste distortion, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, tinnitus, hearing impairment, hypoglycemia, tinnitus, hearing loss, vomiting, nausea, abdominal pain, purpuric rash, acute pancreatitis, increased amylase, elevated AST, elevated ALT, elevated BUN, thrombocytopenia, leukopenia, neutropenia, thrombocytosis, eosinophilia, agranulocytosis, thrombocytopenia, anaphylactic reactions, angioedema, decreased appetite, insomnia, neuroexcitability, loud noises, psychotic disorders, confusional state, abnormal dreams, dyskinesia, non-vestibular dizziness, drowsiness, tremors, vestibular dizziness, hearing impairment, hearing loss, cardiac arrest, atrial fibrillation, premature contractions, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, abnormal liver function tests, bile duct obstruction, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyl transferase, hepatocellular jaundice, vesicular dermatitis, hyperhidrosis, papular rash, acne, Henoch-Schonlein purpura, acute generalized exanthematous pustulosis, muscle cramp, musculoskeletal stiffness, myopathy, elevated urea in blood, nephritis, injection site phlebitis, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated alkaline phosphatase in blood, elevated lactate dehydrogenase in blood, increased international normalized ratio, prolonged prothrombin time, urine color abnormalities, changes in mentation, compulsive behavior, hypokalemia, hypoxemia

This medication is sensitive to light, so it should be stored in containers that do not allow light to enter. Additionally, it is best kept at room temperature between 15 to 30 degrees Celsius, away from excessively hot or cold places.

Appearance

Yellow oval film-coated tablets

Package unit

30 tablets/bottle, 200 tablets/bottle