SimbaDuet Tablet 10/10mg

Adult dose

This medication is taken once daily in the evening, regardless of meals. The dosage range for patients with primary hypercholesterolemia is 10/10mg to 10/40mg per day, and the generally recommended starting dose is 10/20mg daily. Patients who require less reduction in LDL cholesterol can start with 10/10mg once daily. After dosage adjustment, lipid levels should be checked at intervals of four weeks or more to modify the dosage.

This medication can cause serious muscle-related side effects such as myopathy and rhabdomyolysis, so patients must notify their doctor immediately if they experience muscle pain, weakness, or tenderness. This medication should not be administered to patients with poor liver function or active liver disease, and liver function tests should be conducted regularly. Women who are pregnant or breastfeeding should not take this medication, and women planning to become pregnant should consult with a doctor before use. This medication may interact with certain drugs, increasing the risk of muscle side effects, so if taking other medications, patients must inform their doctor or pharmacist, particularly when taking strong CYP3A4 inhibitors, some antibiotics, antifungals, immunosuppressants, and certain heart medications. Elderly patients, those with hypothyroidism, or impaired kidney function are at higher risk for myopathy and should exercise extra caution when taking this medication. This medication can raise blood sugar levels and increase the risk of diabetes, so patients with risk factors for diabetes should regularly monitor their blood sugar levels. Patients taking this medication who experience unexplained muscle pain, weakness, or changes in urine color should notify healthcare professionals immediately, and medication may need to be discontinued if these symptoms occur. This medication should not be administered to patients with certain genetic lactose intolerance, and there is no specific antidote for overdose, so immediate medical attention is necessary in the event of an overdose. Patients taking this medication should inform healthcare professionals of any current medications when being prescribed new ones and must be cautious about drugs that cannot be combined with this medication.

Serious side effects

• Hives
• severe swelling (edema)
• skin peeling
• pain in oral/ocular mucosa
• severe allergic reactions
• severe skin adverse reactions
• difficulty breathing
• respiratory distress
• asthma attacks
• visual disturbances

Mild side effects

• Headache
• diarrhea
• influenza
• upper respiratory infection
• muscle pain
• limb pain
• fatigue
• nausea
• abdominal pain
• constipation

This medication should be stored in a tightly sealed container to protect it from air and moisture. To maintain the drug's efficacy, it is advised to store it at room temperature between 1 and 30 degrees Celsius.

Appearance

White to light yellow, bilaterally convex, rectangular tablet

Package unit

30 tablets per box [30 tablets (10 tablets/PTPX3)]