Tirintal 90 mg (Ticagrelor)

Adult dose

Do not use this medicine concomitantly with other ADP receptor inhibitors (ticlopidine, clopidogrel, prasugrel). Acute coronary syndrome: Administer an initial dose of 180mg, followed by 90mg twice daily. Treatment is recommended for 12 months unless discontinuation of this medicine is clinically necessary. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 150mg), unless specifically contraindicated. Patients with a history of myocardial infarction (occurring at least 1 year previously) who are at high risk of thrombotic cardiovascular events: Administer 60mg twice daily. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 150mg), unless specifically contraindicated. Patients who took 90mg of this medicine or another ADP receptor inhibitor (ticlopidine, clopidogrel, prasugrel) during the first year after myocardial infarction may continue treatment with 60mg of this medicine. Treatment with this medicine may also be initiated in patients within 2 years after myocardial infarction or within 1 year after discontinuation of a previous ADP receptor inhibitor (ticlopidine, clopidogrel, prasugrel). The safety and efficacy of this medicine were evaluated at 3 years of follow-up. Patients with type 2 diabetes who have undergone percutaneous coronary intervention (PCI) for coronary artery disease: Administer 60mg twice daily. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 150mg), unless specifically contraindicated. Refer to the dosage and administration for patients with acute coronary syndrome. Data on the safety and efficacy of this medicine for treatment lasting more than 3 years are limited. Patients with acute ischemic stroke or high-risk transient ischemic attack: Administer an initial dose of 180mg, followed by 90mg twice daily for 30 days. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 100mg), unless specifically contraindicated. An initial loading dose of aspirin (300-325mg) is recommended in patients with acute ischemic stroke or high-risk transient ischemic attack. This medicine is administered orally and may be taken with or without food. For patients who have difficulty swallowing tablets, crush this medicine into a fine powder, disperse it in half a glass of water, and drink the mixture. Rinse the glass with another half glass of water and drink it. This mixture may also be administered through a nasogastric tube (CH8 or larger); it is important to flush the nasogastric tube with water after administration. When switching from another antiplatelet agent to this medicine, start this medicine 24 hours after the last dose of the previous medicine. If a dose is missed, take only 1 tablet (the next scheduled dose) at the next scheduled dosing time. No dosage adjustment is necessary in patients with renal impairment. No dosage adjustment is necessary in patients with mild hepatic impairment. This medicine has not been studied in patients with severe hepatic impairment, and experience with its use in patients with moderate hepatic impairment is limited.

Child dose

Safety and efficacy have not been established in pediatric patients under 18 years of age (see the 'Other' section).

This drug inhibits platelet activity in the blood, preventing blood clots, thus reducing the risk of cardiovascular diseases such as myocardial infarction or stroke. However, this medication may increase the risk of bleeding, so it should not be used in patients who already have bleeding or a history of intracranial hemorrhage. Patients undergoing surgery should discontinue this drug at least 5 days prior to the procedure and should immediately inform their doctor if bleeding symptoms occur. Patients with an allergy to this medication, severe liver dysfunction, or those taking certain strong medications should not use it. Patients at high risk for bleeding, those who have recently undergone surgery, or those with symptoms of bradycardia or dyspnea should use this drug with caution and regularly monitor their condition under a doctor's guidance. This medication may cause side effects such as dyspnea, dizziness, and bleeding, and any unusual symptoms should be reported to healthcare professionals immediately. Pregnant or breastfeeding women should consult their doctor before taking this medication, and women of childbearing age should take appropriate contraceptive measures to avoid pregnancy during treatment. Moreover, it is not recommended for children under 18 years of age as its safety and efficacy have not been established. This medication may interact with other drugs, so it is essential to inform the doctor or pharmacist about any other medications being taken, particularly those metabolized in the liver or those for hypertension or heart conditions. In case of overdose, the risk of bleeding may increase, so it is important to adhere to the prescribed dosage and regimen; if an overdose is suspected, immediately visit a healthcare facility. This medication should be kept out of the reach of children and preferably stored in its original packaging.

Bleeding, intracranial hemorrhage, ocular hemorrhage, ear bleeding, hypotension, dyspnea, respiratory tract bleeding, gastrointestinal bleeding, diarrhea, nausea, dyspepsia, constipation, retroperitoneal hemorrhage, skin bleeding, rash, itching, muscle bleeding, urinary tract bleeding, genital bleeding, elevated serum creatinine, post-procedural bleeding, traumatic bleeding, thrombocytopenic purpura, bradyarrhythmia, atrioventricular block, angioedema, Cheyne-Stokes respiration, central sleep apnea, confusion, dizziness, syncope, headache, vertigo, ear bleeding, chest pain, pulmonary hemorrhage, pharyngitis, upper respiratory infection, asthma, pleural effusion, bronchitis, pneumothorax, pneumonia, pulmonary edema, malaise, anaphylactic shock, epistaxis, hemoptysis, hematoma, cerebral hemorrhage, spinal canal stenosis, dementia, migraine, paralysis, gait disturbance, rectal bleeding, anal bleeding, appendicitis, tendonitis, bursitis, rhabdomyolysis, hepatitis, snoring, aneurysm, heart failure, cardiac rhythm disorder, palpitations, ventricular tachycardia, arrhythmia, ventricular fibrillation, cardiac arrest, ventricular fibrillation, urinary tract infection, kidney stones, cerebral ischemia, venous stenosis, cerebral infarction, arterial stenosis, angina, coronary thrombosis, myocardial ischemia, myocardial infarction, anemia, vestibular disorders, malignant neoplasm of male reproductive organs, chemical poisoning, post-procedural hematoma, laceration, road traffic accident, trauma, nausea, vomiting, acute renal failure, hyperuricemia, gout, coma, speech disorders, brainstem hypoxia, scalp tenderness, peripheral neuropathy, neck stiffness, vocal disorders, seizures, neuropathy, neuralgia, movement disorders, tremors, lower limb paralysis, oral pain, gastritis, belching, irritable bowel syndrome, stomatitis, ulcerative stomatitis, benign gastrointestinal neoplasm, dental disease, tongue disease, tendinopathy, arthritis, chondrocalcinosis, spinal osteoarthritis, arthritis, contact dermatitis, fungal dermatitis, skin disease, erythematous rash, keratinization, acute urticaria, onychomycosis, hair loss, scleroderma, soft fibroma of the skin, increased sweating, hyperlipidemia, hypertriglyceridemia, exacerbation of diabetes, hypercholesterolemia, lipodystrophy, dehydration, hepatitis, cholelithiasis, gallbladder disease, increased alkaline phosphatase, fatty liver, drowsiness, neurosis, depression, cognitive impairment, erectile dysfunction, anxiety, insomnia, anxiety, orthostatic hypotension, exacerbation of hypertension, cyanosis, palpitations, bradycardia, atrial fibrillation, frequent urination, dysuria, urinary tract infection, conjunctival hyperemia, ocular pain, visual disturbances, synchronized rhythm, atrial arrhythmia, pericardial effusion, abscess, oral candidiasis, herpes zoster, bacterial infection, esophageal candidiasis, decreased blood iron, tinnitus, ear pain, lymphadenopathy, eosinophilia, sexual dysfunction, benign prostatic hyperplasia, ovarian cyst, amenorrhea, vaginitis, loss of taste, altered smell, increased TSH, hypothyroidism, injection site reaction, injection site pain

This medication should be stored in a tightly closed container to protect it from air and moisture, preferably at room temperature between 1°C and 30°C.

Appearance

A yellow, round, biconvex, film-coated tablet

Package unit

56 tablets / [(14 tablets PTP x 4)]