Pantoprazole Sodium Sesquihydrate 40 mg Tablet

Adult dose

1. Combination therapy with antibiotics to prevent recurrence of gastroduodenal ulcers associated with Helicobacter pylori infection - The usual adult dose is 40 mg of pantoprazole per dose, administered twice daily (before breakfast and dinner) in combination with the following antibiotics for 1 week. Swallow whole; do not chew or crush. (1) Take 1,000 mg of amoxicillin and 500 mg of clarithromycin per dose twice daily for 1 week, or (2) Take 500 mg of metronidazole and 500 mg of clarithromycin per dose twice daily for 1 week, or (3) Take 1,000 mg of amoxicillin and 500 mg of metronidazole per dose twice daily for 1 week. - The metronidazole regimens in (2) and (3) should be used only when regimen 1 is inappropriate. - If additional treatment with pantoprazole is indicated to ensure ulcer healing, consider the recommended doses and regimens below for duodenal and gastric ulcers. - If combination therapy is not needed (e.g., negative for Helicobacter pylori infection), use pantoprazole monotherapy according to the regimens below. 2. Gastric ulcer and reflux esophagitis - The usual adult dose is 40 mg of pantoprazole once daily, taken with water before breakfast. Swallow whole; do not chew or crush. - Most cases may heal within 4 weeks, although healing time may vary among patients. If not healed after the first 4 weeks, continue treatment for another 4 weeks. - If there is no response to other treatment in particular, the dose may be doubled (to 80 mg of pantoprazole daily). 3. Duodenal ulcer - The usual adult dose is 40 mg of pantoprazole once daily, taken with water before breakfast. Swallow whole; do not chew or crush. - Most cases may heal within 2 weeks, although healing time may vary among patients. If not healed after the first 2 weeks, continue treatment for another 2 weeks. - If there is no response to other treatment in particular, the dose may be doubled (to 80 mg of pantoprazole daily). 4. Zollinger-Ellison syndrome and other pathological hypersecretory conditions - Start with an initial dose of 80 mg of pantoprazole daily, then increase or decrease the dose according to measurements of gastric acid secretion. - Doses exceeding 80 mg should be divided into 2 doses per day. - A temporary increase to 160 mg or more is possible, but should be used only for as long as necessary to achieve adequate acid control. - The duration of treatment is not limited, but should be changed according to clinical need. ○ In patients with severe hepatic impairment (liver impairment), reduce the dose so that it does not exceed 20mg of pantoprazole once daily. ○ In elderly patients or patients with renal impairment, do not exceed 40 mg of pantoprazole daily. As an exception, elderly patients may take 40 mg of this medicine per dose twice daily (before breakfast and dinner) for 1 week as part of the antibiotic combination therapy described above. Swallow whole; do not chew or crush. ○ Do not use antibiotic combination therapy in patients with moderate to severe hepatic/renal impairment. There are insufficient data on the efficacy and safety of this combination therapy.

This medication should not be administered to patients with moderate to severe impairment of liver or kidney function due to insufficient clinical experience regarding safety and efficacy. Patients who have experienced hypersensitivity to this medication, its components, or benzimidazole derivatives may experience serious allergic reactions, such as anaphylaxis, angioedema, and bronchospasm, and should not use this medication. Patients with hypersensitivity to certain specific antibiotics used in combination with this medication should also avoid it, and it is recommended that pregnant women in early pregnancy, women who could become pregnant, and breastfeeding women do not use this medication. Various gastrointestinal symptoms, headache, dizziness, depression, skin rash, and other side effects may appear during treatment with this medication, so if any abnormal symptoms occur, immediate consultation with a healthcare professional is required. Long-term use may reduce the acidity in the stomach, which could increase the risk of some bacterial infections and higher fracture risk, thus regular check-ups are necessary. This medication may interact with other drugs, so it is crucial to inform the prescribing doctor or pharmacist, especially if you are taking anticoagulants, antivirals, or antibiotics. Pregnant or breastfeeding women should avoid use due to potential effects on the fetus or infant, and if necessary, sufficient consultation with a specialist is required. Safety in children and adolescents has not been thoroughly validated, so caution is required with use. In the case of overdose, there is no specific antidote, so appropriate treatment should be received based on symptoms. When taking, do not chew or crush the tablet but swallow it whole, and store it in a safe place out of reach of children.

• Abdominal pain
• constipation
• distension
• diarrhea
• nausea
• vomiting
• belching
• dry mouth
• fatigue
• asthenia

Store this medication in a closed container that can block light, safely at a temperature between 1 degree and 30 degrees Celsius. Storing it this way ensures that the ingredients do not change and that effectiveness is well maintained.

Appearance

Yellow, enteric-coated oval tablet

Package unit

30 tablets/bottle