Sincra 625 mg (Amoxicillin-Potassium Clavulanate)

Adult dose

For adults and children aged 12 years or older or weighing 40 kg or more, administer Amoxicillin/Potassium Clavulanate 250 mg/125 mg orally every 8 hours, three times a day. In cases of severe infections or respiratory infections, the dose may be increased to 500 mg/125 mg. For those with kidney impairment, dosage adjustments should be based on creatinine clearance as follows: - Creatinine clearance 10 - 30 mL/min: 25 mg of Amoxicillin is administered every 12 hours.

Child dose

Children receive dosage reductions as per adult protocols.

This medication should not be used in certain patients. Patients who have had allergic reactions to this medication or beta-lactam antibiotics, patients with viral infections such as infectious mononucleosis or lymphocytic leukemia, and those with a history of liver dysfunction or jaundice due to this medication or penicillin-related drugs should not take this medication. Patients with impaired liver function or severe kidney impairment should use this medication more cautiously. Caution is also needed for patients with a history of allergies, gastrointestinal symptoms such as vomiting and diarrhea, as well as elderly patients or those in poor health. Various side effects can occur during treatment with this medication, especially gastrointestinal issues such as diarrhea, abdominal pain, and vomiting are commonly reported. Rarely, various side effects such as liver dysfunction, skin rash, allergic reactions, blood abnormalities, neurological symptoms, and kidney problems can occur, so immediate consultation with a doctor is necessary if any unusual signs appear. It is important to regularly monitor liver and kidney function and blood status during the use of this medication. Additionally, this medication may interact with other drugs, so it is essential to inform healthcare providers about any other medications being taken, especially when using it alongside anticoagulants or certain antibiotics. Women who are pregnant or breastfeeding should carefully weigh the risks and benefits before using this medication, especially avoiding use during the first three months of pregnancy. Caution is needed when administering this medication to children and the elderly, as the elderly may be at higher risk of bleeding due to vitamin K deficiency, and their condition should be closely monitored. In case of overdose, gastrointestinal symptoms, renal failure, rashes, and seizures may occur, so immediate discontinuation and appropriate treatment should be sought. This medication should be stored away from direct sunlight in a cool, dry place at or below 25 degrees Celsius.

Serious side effects

• Severe allergic reactions: hives, anaphylaxis, angioedema, symptoms of hypotension, anaphylactic shock, acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), blistering dermatitis.
• Severe skin adverse reactions: severe rash, blisters, skin peeling, pain in the mucous membranes of the mouth/eyes.
• Respiratory issues: difficulty breathing, asthma attacks, dyspnea associated with bronchospasm.

Mild side effects

• Gastrointestinal: diarrhea
• pseudomembranous colitis
• dyspepsia
• stomatitis
• gastritis
• glossitis
• nausea
• vomiting
• loss of appetite
• abdominal pain

This medication should be stored in a sealed container to avoid moisture, preferably in a cool and dry place at or below 25 degrees Celsius. By storing it this way, the effectiveness of the medication can be preserved and deterioration can be prevented.

Appearance

White or almost white oval film-coated tablets

Package unit

40 tablets (4 tablets/PTP*10), 60 tablets (6 tablets/PTP*10)