K-Met Extended-Release Tablet (Metformin Hydrochloride)

Adult dose

Administer 500mg of Metformin Hydrochloride Extended-Release tablets once daily with the evening meal. Adjust the dose based on blood sugar levels after one week, increasing by 500mg weekly up to a maximum daily dose of 2000mg with the evening meal. If blood sugar control is not achieved, consider administering 1000mg twice daily (with meals). For patients with renal impairment, the initial dosage is 500mg or 750mg once daily.

This medication is used for the treatment of diabetes and may rarely cause a serious condition called lactic acidosis, so caution is required. If taken with other diabetes medications, there is a possibility of hypoglycemia, thus careful monitoring of blood sugar levels is needed. Patients with moderate to severe impaired renal function, dehydration, severe infections, heart failure, or acute conditions affecting kidney function such as acute myocardial infarction should not take this medication. When undergoing tests involving radiocontrast iodine agents, this medication should be discontinued prior to the examination and can be resumed only after normal kidney function is confirmed. Patients with allergies to this medication, type 1 diabetes, diabetic ketoacidosis, or other specific metabolic disorders should not use it. Severe infections or trauma, pre-and post-surgery, malnutrition, liver dysfunction, excessive alcohol consumption, etc., may necessitate temporary discontinuation of this medication. Patients with irregular eating patterns, excessive exercise, or concurrent use of interacting medications should use this medication cautiously as there is a risk of lactic acidosis and hypoglycemia. During treatment, side effects such as vitamin B12 deficiency, impaired taste, gastrointestinal disturbances (nausea, vomiting, diarrhea, abdominal pain, etc.), and skin rashes may occur. If any unusual symptoms arise, consultation with a physician is advised. This medication is excreted by the kidneys, so regular monitoring of kidney function is necessary, and treatment should be discontinued if function worsens. Alcohol can increase the risk of side effects from this medication, so excessive drinking should be avoided during treatment. During pregnancy, careful consideration of the potential effects on the fetus is necessary, and it is not recommended while breastfeeding. Elderly patients may have decreased renal function; hence, dosage should be adjusted accordingly and kidney function should be monitored regularly. In case of overdose, blood dialysis may be used to remove the drug, so medical attention should be sought immediately. Maintaining regular meals and exercise along with regular blood sugar and kidney function checks is very important during treatment. The tablets should be swallowed whole and not crushed or chewed. Additionally, several medications may interact with this drug, so be sure to inform healthcare providers about any other medications being taken.

Serious side effects

Lactic acidosis, severe lactic acidosis, severe allergic reactions (hives, severe swelling, chest tightness, difficulty breathing, cold sweats, paleness), severe skin reactions (severe rash, blisters, skin peeling, pain in oral/ocular mucosa), respiratory issues (difficulty in breathing or breathing difficulties, asthma attacks, breathing abnormalities accompanied by cough and fever), liver abnormalities (yellowing of skin or eyes, extreme lethargy), serious neurological symptoms

Mild side effects

• Vitamin B12 deficiency
• impaired taste
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• erythema
• itching
• hives

This medication should be stored in a tightly sealed container to avoid exposure to air or moisture, and it is best kept at room temperature between 1 to 30 degrees Celsius. Proper storage helps maintain the drug's efficacy.

Appearance

White, double convex, rectangular extended-release tablet

Package unit

30 tablets/bottle, 300 tablets/bottle