Beaquel Tablet 25 mg (Quetiapine Fumarate)

Adult dose

Schizophrenia Adults: This medicine is taken twice daily, with or without food. The total daily dose for the first 4 days is 50 mg on Day 1, 100 mg on Day 2, 200 mg on Day 3, and 300 mg on Day 4. From Day 4 onward, the dose should be adjusted to the usual effective daily dose of 300～400 mg. Depending on the individual patient's clinical response and drug tolerability, the dose may be adjusted within the range of 150～750 mg/day. Maintenance treatment has not been evaluated in adults with schizophrenia. Patients should be reassessed regularly to determine the need for maintenance treatment. Acute treatment of manic episodes associated with bipolar I disorder Adults: This medicine is taken twice daily, with or without food. As monotherapy or adjunctive therapy to a mood stabilizer (lithium or valproate), the total daily dose for the first 4 days is 100 mg on Day 1, 200 mg on Day 2, 300 mg on Day 3, and 400 mg on Day 4. The total daily dose may be increased to 800 mg by Day 6, in increments of no more than 200mg per day. Depending on the individual patient's clinical response and drug tolerability, the dose may be adjusted within the range of 200～800 mg/day; the usual effective daily dose is 400～800 mg. Treatment of depression associated with bipolar disorder Adults: This medicine is taken once daily at bedtime, with or without food. The total daily dose for the first 4 days should reach 50 mg on Day 1, 100 mg on Day 2, 200 mg on Day 3, and 300 mg on Day 4. In confirmatory clinical trials of this medicine, doses of 50 mg on Day 1, 100 mg on Day 2, 200 mg on Day 3, 300 mg on Day 4, 400 mg on Day 5, and up to 600 mg on Day 8 were administered. The recommended daily dose is 300 mg. Antidepressant effects were observed at both 300 mg and 600 mg, but there was no additional benefit at 600 mg. Increases above 300 mg should be initiated by a physician experienced in treating bipolar disorder. In patients who tolerate the medicine, clinical trials indicate that the dose may be reduced to as low as 200 mg. Prevention of recurrence of bipolar disorder Adults: To prevent recurrence of manic, mixed, or depressive episodes associated with bipolar disorder, patients who responded to quetiapine for acute treatment of bipolar disorder should continue on the same dose. Depending on clinical response and each patient's tolerability, the dose may be adjusted within the range of 300～800 mg/day, administered twice daily. It is important to use the minimum effective dose for maintenance treatment. Elderly patients: Elderly patients should start with 25 mg/day, with gradual increases of 25～50 mg per day. The effective dose in elderly patients may be lower than that in younger patients. Patients with renal or hepatic impairment: Patients with renal or hepatic impairment should start with 25 mg/day, with gradual increases of 25～50 mg per day until an effective dose is reached.

Child dose

Children and adolescents: The safety and efficacy of this medicine have not been established in children and adolescents.

This medication is mainly used for the treatment of psychiatric disorders, particularly prescribed for depression, schizophrenia, and bipolar disorder. During treatment, there may be an increased risk of suicidal thoughts or behavior, particularly in young patients aged 18 to 24, who require close monitoring by a physician. Due to the risk of elevated blood sugar, diabetic patients or those with a family history of diabetes should monitor blood sugar levels regularly, and if symptoms of hyperglycemia such as thirst or frequent urination occur, they should consult a physician immediately. Rarely, serious side effects can occur, such as neuroleptic malignant syndrome, an emergency condition characterized by high fever, muscle rigidity, and changes in mental state. If symptoms are suspected, immediate medical attention is required. Prolonged use may lead to movement-related side effects such as extrapyramidal symptoms or tardive dyskinesia; if these symptoms occur, consideration should be given to dose adjustment or discontinuation. It is not recommended for elderly patients with dementia, as there may be an increased risk of death. This medication can cause decreased white blood cell count or severe neutropenia, so medical evaluation should be sought immediately in case of symptoms of infection. Patients with cardiovascular disease or hypotension should be closely monitored for orthostatic hypotension or cardiac abnormalities when taking this medication. Severe skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis can occur, so if skin rashes or fever develop, medication should be stopped immediately and consultation with healthcare professionals should occur. This medication is not administered to patients with hypersensitivity to certain components, those in a comatose state, patients taking strong central nervous system depressants, patients receiving epinephrine, or diabetic patients. Patients with liver dysfunction, a history of cardiovascular disease, seizure disorders, the elderly, pregnant women or those of childbearing potential should use it cautiously, with appropriate dose adjustments and monitoring. Due to many potential drug interactions, caution is necessary when taking other central nervous system medications or alcohol, and in combination with certain antifungals or antibiotics, drug concentrations may change significantly, so it should be taken as directed by a physician. Pregnant or breastfeeding women should consult a physician before taking this medication as it could affect the fetus or newborn. Common side effects may include drowsiness, dizziness, dry mouth, weight gain, constipation, etc. Caution is needed when driving or operating dangerous machinery. Sudden cessation may lead to withdrawal symptoms, so doses should be reduced gradually as directed by a physician. In case of overdose, there is no specific antidote, so immediate medical attention should be sought; severe symptoms such as decreased consciousness and cardiac abnormalities may occur. This medication is not recommended for use in children and adolescents, as safety and efficacy have not been established.

• Drowsiness
• dizziness
• dry mouth
• withdrawal symptoms
• increased triglyceride levels
• increased total cholesterol
• decreased HDL cholesterol
• weight gain
• decreased hemoglobin
• extrapyramidal symptoms

This medication should be stored in a sealed container to prevent air or moisture from entering, and should be kept at a temperature below 30 degrees Celsius. Storing it this way will help maintain the medication's effectiveness for a long time.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle