Neurofedone Tablet 1 mg (Risperidone)

Adult dose

The therapeutic dose of this drug should be adjusted according to the patient's clinical condition, and the lowest effective dose possible should be administered. Schizophrenia—Adults: Initial dose: Administer 1 mg of risperidone orally twice daily and increase gradually. Maintenance dose: Administer 1–3 mg twice daily. Adjust the dose appropriately according to the patient's age and symptoms. No additional efficacy was observed with doses of 10 mg or more per day compared with lower doses, and such doses may increase the risk of extrapyramidal symptoms. Doses of 10 mg or more per day should be administered only when the benefits for the individual patient are considered to outweigh the risks. Do not administer doses of 16 mg or more per day, as safety has not been established. A benzodiazepine may be coadministered if additional sedation is required. Schizophrenia—Elderly patients and patients predisposed to hypotension: The initial dose is 0.5 mg twice daily. Depending on the patient's condition, increase the dose by 0.5 mg twice daily until a dose of 1–2 mg twice daily is reached. In general, increases to doses of 1.5 mg or more twice daily should be made at intervals of at least 1 week. Switching from other antipsychotic drugs to this drug: When medically appropriate, initiate this drug while gradually reducing the dose of the existing medication. Also, when medically appropriate, when switching from an existing depot antipsychotic drug, initiate this drug in place of the next scheduled injection of the depot formulation. The need to continue any concomitant antiparkinsonian medication should be reassessed regularly. Agitation, aggression, or psychotic symptoms in patients with dementia of the Alzheimer type: The initial dose is 0.25 mg of this drug twice daily. If necessary, depending on the patient, the dose may be increased by 0.25 mg twice daily at intervals of at least 2 days. The optimal dose for most patients is 0.5 mg twice daily, but the dose may be increased to 1 mg twice daily depending on the patient. Once the patient has reached the optimal dose, once-daily administration may also be considered. As with symptomatic treatment, the rationale for continued use of this drug should be evaluated. Adjunctive treatment of mania in bipolar disorder: The recommended initial dose is 2 mg of this drug once daily. Depending on the patient, the dose may be increased by 1 mg per day at intervals of 24 hours or more. The optimal dose for most patients is in the range of 2–6 mg per day. As with symptomatic treatment, the rationale for continued use of this drug should be evaluated. As with symptomatic treatment, the rationale for continued use of this drug should be evaluated. Renal and hepatic impairment: In patients with renal or hepatic impairment, administer half the initial and maintenance doses and adjust the dose more gradually. Exercise caution when administering this drug to these patients (see 5. General Precautions).

Child dose

Schizophrenia: There is limited clinical experience in children and adolescents under 15 years of age. Adjunctive treatment of mania in bipolar disorder: There is limited clinical experience in children and adolescents under 15 years of age. Conduct disorder and other disruptive behavior disorders—body weight 50 kg or more: The initial dose is 0.5 mg of this product once daily. If needed, the dose may be increased by 0.5 mg per day at intervals of at least 2 days. For most patients, the optimal dose is 1 mg once daily. Depending on the patient, 0.5∼1.5 mg may be administered once daily. Conduct disorder and other disruptive behavior disorders—body weight less than 50 kg: The initial dose is 0.25 mg once daily. If needed, the dose may be increased by 0.25 mg per day at intervals of at least 2 days. For most patients, the optimal dose is 0.5 mg once daily. Depending on the patient, 0.25∼0.75 mg may be administered once daily. Conduct disorder and other disruptive behavior disorders: There is limited clinical experience in children under 5 years of age.

Care must be taken when using this medication in elderly dementia patients as it may increase mortality. Careful consideration of risks and benefits is required before co-administering this drug with certain diuretics (Furosemide) in elderly dementia patients, as the risk of mortality may be higher. This drug may increase the risk of venous thromboembolism, thus risk factors for thrombosis should be identified and preventive measures taken before and during administration. Patients with a known allergy to this drug or its components, those in a state of central nervous system depression, patients in a coma, those receiving epinephrine, and some genetically lactose intolerant patients should not use this medication. Patients with cardiovascular disease, impaired liver or kidney function, a history of seizures, those at risk of suicide, diabetic patients, elderly individuals, pregnant women, and nursing mothers should use this medication with caution. This drug can cause various neurological adverse reactions, such as drowsiness, dizziness, orthostatic hypotension, Parkinsonian symptoms, and muscle rigidity, so immediate consultation with a doctor should be sought if symptoms occur. During treatment, it is necessary to regularly monitor blood sugar and weight changes, and if there are any signs of infection or leukopenia, prompt testing is required. This drug can interact with other central nervous system depressants, antihypertensives, and medications that prolong the QT interval, so caution is advised when co-administered. Pregnant or nursing women should only use this medication when necessary, considering the effects on the fetus and newborn, and it is recommended to discontinue nursing during treatment. In case of overdose, immediate medical attention should be sought for appropriate emergency treatment, as there is no specific antidote and supportive treatment is needed for the symptoms. This drug should be kept out of the reach of children and should not be transferred to other containers; it is advisable to take it immediately after opening. Do not mix this medication with tea, cola, or black tea, as there may be precipitation in the liquid formulation.

Increased mortality, cerebrovascular adverse reactions, venous thrombosis, rhinopharyngitis, upper respiratory tract infection, sinusitis, urinary tract infection, anemia, hypersensitivity reactions, insomnia, anxiety, nervous irritability, Parkinsonism, akathisia, drowsiness, dizziness, sedation, tremors, muscle tone abnormalities, hypersomnolence, orthostatic dizziness, movement disorders, syncope, blurred vision, ear pain, orthostatic hypotension, tachycardia, hypotension, nasal congestion, dyspnea, epistaxis, sinus congestion, nausea, constipation, dyspepsia, vomiting, diarrhea, excessive salivation, dry mouth, abdominal discomfort, abdominal pain, gastrointestinal discomfort, epigastric pain, rash, dry skin, dandruff, seborrheic dermatitis, hyperkeratosis, back pain, arthralgia, limb pain, urinary incontinence, ejaculatory dysfunction, fatigue, asthenia, fever, chest pain, elevated blood creatinine phosphokinase, increased heart rate, pneumonia, soft tissue inflammation, decreased appetite, confusion, transient ischemic attack, decreased consciousness, drooling, cerebrovascular accident, conjunctivitis, hypotension, cough, runny nose, dysphagia, fecal impaction, erythema, abnormal posture, joint swelling, peripheral edema, gait disturbance, pitting edema, elevated body temperature, upper respiratory tract infection, rhinitis, influenza, increased appetite, middle insomnia, lethargy, headache, stuttering, attention disorder, balance disorder, hypersomnia, palpitations, pharyngeal and laryngeal pain, pulmonary congestion, itching, acne, myalgia, neck pain, nocturia, polyuria, galactorrhea, emotional disturbances, apathy, chest discomfort, elevated blood prolactin, agranulocytosis, thrombocytopenia, abnormal secretion of antidiuretic hormone, diabetic ketoacidosis, diabetes mellitus, hypoglycemia, water intoxication, mania, altered taste, intraoperative mydriatic hypotension syndrome, atrial fibrillation, deep vein thrombosis, pulmonary embolism, obstructive sleep apnea syndrome, intestinal obstruction, pancreatitis, jaundice, angioedema, hair loss, neonatal drug withdrawal syndrome, urinary retention, persistent erection, hypothermia, prolonged QT interval in ECG, anaphylactic reaction, depression, early insomnia, delusions, hallucinations, paranoid delusions, suicide attempts, increased libido, decreased libido, sexual dysfunction, unresponsiveness to stimuli, abnormal cooperation, loss of consciousness, speech disorders, sensory loss, movement disorders, generalized hyperkinesia, cerebral ischemia, cerebrovascular accident disorder, neuroleptic malignant syndrome, diabetic coma, head tremor, seizures, psychomotor hyperactivity, delayed dyskinesia, cerebrovascular disorders, sensory abnormalities, conjunctival injection, eye discharge, eye movement, eyelid edema, photophobia, eyelid crusting, dry eyes, increased tearing, glare, glaucoma, decreased vision, tinnitus, dizziness, sinus bradycardia, sinus tachycardia, palpitations, type I atrioventricular block, left bundle branch block, right bundle branch block, atrioventricular block, flushing, conduction disorders, abnormal ECG, prolonged QT interval on ECG, sinus venous, bradycardia, wheezing, aspiration pneumonia, voice disorders, wet cough, airway congestion, crackles, respiratory disorders, nasal edema, hyperventilation, fecal incontinence, gastritis, lip swelling, cheilitis, salivary deficiency, flatulence, gastroenteritis, tongue swelling, toothache, skin discoloration, skin lesions, skin disorders, erythematous rash, papular rash, generalized rash, papulopustular rash, eczema, musculoskeletal chest pain, joint stiffness, muscle weakness, rhabdomyolysis, urinary dysfunction, amenorrhea, gynecomastia, vaginal discharge, erectile dysfunction, ejaculatory disorder, menstrual disorders, breast engorgement, sexual dysfunction, retrograde ejaculation, breast discharge, thirst, influenza-like syndrome, edema, malaise, facial swelling, discomfort, generalized edema, chills, peripheral coldness, drug withdrawal syndrome, adverse drug reactions, decreased body temperature, procedure-related pain, increased ALT, abnormal ECG findings, eosinophilia, increased AST, decreased white blood cell count, increased blood glucose, decreased hemoglobin, decreased hematocrit, reduced body temperature, decreased blood pressure, increased transaminases, increased γ-glutamyltransferase, increased liver enzymes, anxiety, blunted affect, sleep disorders, decreased sexual desire, nightmares, suicide attempts, accident anomalies, delusions, exacerbation of hallucinations and auditory hallucinations, delayed movement abnormalities, neuroleptic malignant syndrome, falls, persistent erection, orthostatic hypotension, syncope, exacerbation of extrapyramidal symptoms, hyperglycemia, worsening of diabetes, weight gain, sedative effect, leukopenia, neutropenia, intraoperative mydriatic hypotension syndrome, drug withdrawal syndrome, increased sweating, hiccups, hangover, tic disorders, Rabbit syndrome

This medication must be stored in a tightly sealed container to protect it from air and moisture. It is recommended to maintain a storage temperature between 1 and 30 degrees Celsius (room temperature) for optimal preservation of effectiveness.

Appearance

Oblong white film-coated tablets

Package unit

30 tablets/bottle, 200 tablets/bottle