Famciclovir Tablets 250 mg (Famciclovir)

Adult dose

1. Treatment of herpes zoster infection Adults: Administer famciclovir 250 mg orally 3 times daily for 7 days. It is preferable to start treatment as soon as symptoms appear after infection. 2. Treatment of an initial episode of genital herpes infection Adults: Administer this medicine 250 mg orally 3 times daily for 5 days. It is preferable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes infection Adults: Administer this medicine 125 mg orally twice daily for 5 days. It is preferable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer this medicine 250 mg orally twice daily. Discontinue treatment periodically every 6～12 months to assess any change in the natural course of the disease. 5. Patients with renal impairment: Because the creatinine clearance of this medicine is decreased in patients with renal impairment, adjust the dose with caution. The dosage for these patients is as follows. 1) Treatment of herpes zoster and an initial episode of genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59: 250 mg per dose twice daily Creatinine clearance (mL/min/1.73㎡) 10～29: 250 mg per dose once daily 2) Treatment of acute recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59: 125 mg per dose twice daily Creatinine clearance (mL/min/1.73㎡) 10～29: 125 mg per dose once daily 3) Suppression of recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59: 250 mg per dose twice daily Creatinine clearance (mL/min/1.73㎡) 10～29: 125 mg per dose twice daily 4) If only serum creatinine is known, creatinine clearance can be calculated using the following formula. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis Patients on hemodialysis should preferably receive this medicine every 48 hours, taking the dialysis interval into account. A 4-hour hemodialysis session reduces the plasma concentration of this medicine by approximately 75%, so administer this medicine immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dose adjustment is necessary for patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, no clear recommended dose has been established.

This drug should not be used in certain patients. For example, patients who have had an allergic reaction or hypersensitivity to this drug or its components should not take it. Additionally, patients with a genetic condition that prevents lactose digestion should not take this drug as it contains lactose. Patients allergic to soybean oil, soy, or peanuts should also avoid this drug. Caution should be exercised when administering this drug to patients with impaired kidney function or problems with fat metabolism. These patients may be affected by the side effects or metabolism of the drug, necessitating careful monitoring. Side effects such as headache, dizziness, nausea, vomiting, skin rash, and itching may occur while taking this medication. Elderly patients may experience symptoms such as drowsiness or confusion more frequently, and caution should be taken in these cases. Serious side effects such as thrombocytopenia or acute renal failure have been reported sporadically, so if any unusual symptoms occur, immediate consultation with medical professionals is recommended. This drug cannot completely cure genital herpes, so it is important to avoid sexual contact when symptoms are present and to maintain safe sexual practices. Patients should be educated to start treatment quickly when recurrence symptoms appear. If dizziness, drowsiness, or confusion occurs while taking this medication, patients should refrain from driving or operating machinery. Patients with mild to moderate liver functional impairment do not require special dosage adjustments; however, caution should be exercised in patients with severe liver impairment as the effectiveness of this drug may decrease. This drug is unlikely to interact with other drugs, but patients should inform medical professionals of any medications they are taking as drug concentrations may change when used with certain other medications. Pregnant women or nursing mothers should use this drug cautiously only when necessary, as its safety has not been entirely established. Children under 18 years of age should not use this drug as its safety and efficacy have not been confirmed. Elderly patients generally do not require dosage adjustments, but if renal function is impaired, the dosage should be adjusted. In case of overdose, immediate hospitalization for appropriate treatment is required, and blood dialysis can lower the drug's concentration in the body. This drug should be stored in a cool, dry place below 30 degrees Celsius and kept out of reach of children. Transferring it to another container may negatively impact quality and should be avoided.

• headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucinations
• palpitations

This drug is sensitive to air and moisture, so it must be kept in a tightly sealed container. It is also recommended to store it in a cool, dry place below 30 degrees Celsius.

Appearance

White, round film-coated tablets

Package unit

21 tablets per bottle