Simetidin Tablet (Cimetidine)

Adult dosage

Adults: Administer Cimetidine as a single dose of 400 mg twice daily (morning, bedtime) orally, or 800 mg once daily (bedtime). Additionally, administer 300 mg four times daily (after meals, at bedtime) orally. The dose may be increased to 400 mg four times daily (after meals, at bedtime) (total 1.6 g). For improvement of gastric mucosal lesions: In cases of acute gastritis and acute exacerbation of chronic gastritis, administer 200 mg twice daily.

Children's dosage

Children: Administer orally in divided doses of 20-40 mg per kg of body weight per day.

This medication contains the ingredient cimetidine and is used to inhibit gastric acid secretion for the treatment of peptic ulcers or gastroesophageal reflux disease. This drug should not be administered to patients with allergic reactions to cimetidine or other ingredients, or those at risk of specific cardiac arrhythmias. Additionally, patients with lactose intolerance or hereditary glucose absorption disorders should avoid taking this medication. Patients with impaired renal or liver function, elderly patients, individuals under 19 years of age, and patients undergoing dialysis should use this medication with caution, and may require dosage adjustments or longer dosing intervals. During the course of this medication, it is important to regularly conduct blood tests, liver function tests, and kidney function tests to detect any adverse reactions early. Various side effects may occur such as decreased blood cell counts, hepatitis, elevated AST and ALT, interstitial nephritis, urinary retention, increased BUN, gynecomastia, excessive milk secretion, increased vaginal discharge, erectile dysfunction, abdominal bloating, constipation, diarrhea, headaches, dizziness, limb numbness, stiffness, drowsiness, hypochondriac symptoms, and weakness. Particular attention is needed as neurological abnormal symptoms such as confusion or seizures can occur especially in elderly patients or those with renal failure. This medication may interact with various other drugs, so it is crucial to inform healthcare professionals if you are taking other medications as some may require dose adjustments. Women who are pregnant or nursing should carefully consider the impact of this medication on the fetus or newborn, and it is recommended to discontinue breastfeeding while taking this medication. In case of overdose, serious symptoms such as respiratory depression may occur, and immediate emergency treatment should be sought. Keep this medication out of reach of children, and do not change the container.

Serious side effects

• General malaise, weakness, subcutaneous hemorrhage, mucosal hemorrhage, fever (early signs of blood system abnormalities)
• Jaundice, hepatic dysfunction
• Fever, abnormal kidney function tests (elevated BUN, creatinine level, etc.)
• Shock, anaphylactic-like reactions, respiratory distress
• Altered consciousness, convulsions
• Stevens-Johnson syndrome, toxic epidermal necrolysis, epidermal necrosis, erythema multiforme, exfoliative dermatitis, generalized exfoliative erythema edema
• Respiratory depression accompanied by cyanosis of the lips

Mild side effects

• Leukopenia
• granulocytopenia
• agranulocytosis
• thrombocytopenia
• pancytopenia
• aplastic anemia
• immune hemolytic anemia
• hepatitis
• elevation of AST and ALT
• hepatic fibrosis

This medication is sensitive to light and should be stored in a container that does not allow light to enter. Additionally, it is important to maintain a room temperature between 1°C and 30°C when storing the medication. Doing so will help safely preserve its effectiveness.

Appearance

Pale green-green round film-coated tablet

Package unit

For domestic use - 30 tablets/bottle, For domestic use - 1000 tablets/bottle