Clarithromycin 250 mg (Clarithromycin)

Adult dosage

○ Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7～14 days. In patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer to these patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it should be co-administered with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Helicobacter pylori eradication in patients with duodenal ulcers: Co-administer 500mg (potency) of this medicine 3 times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

Children aged 12 years and older: Same as adults For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be administered to patients with certain medications or health conditions. For example, it should not be used if there is an allergy to any of its components or if there is a hypersensitivity to certain antibiotics. Caution is also needed for patients with arrhythmia or severely impaired liver or kidney function. It is safer for pregnant or breastfeeding women not to use this medication. It can interact with multiple other drugs, so if any other medications are being taken, a consultation with a doctor or pharmacist is necessary. During treatment, side effects such as allergic reactions, gastrointestinal disturbances, liver dysfunction, kidney dysfunction, and skin rashes may occur, so symptoms should be carefully monitored. Particularly, if severe allergic reactions or symptoms of cardiac issues occur, use of the drug should be immediately stopped and healthcare professionals informed. Long-term or high-dose use of this drug may cause tinnitus or hearing loss, so if such symptoms occur, consulting a doctor is advisable. Elderly patients or those with declining liver or kidney functions may require dosage adjustments, and regular examinations to monitor their condition are important. If persistent diarrhea or abdominal pain develops while taking this medication, immediate consultation with healthcare professionals is necessary. Furthermore, this drug may affect driving or operation of machinery, so caution is needed. In cases of overdose, gastrointestinal symptoms or central nervous system disturbances may appear, requiring immediate treatment.

Shock, anaphylactic symptoms, dyspnea, seizures, erythema, rash, itching, hives, skin erythema, angioedema, joint swelling, drug eruption, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, gas retention, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, loss of appetite, constipation, discoloration of stool, enterocolitis, hemorrhagic colitis, fever, cough, dyspnea, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute exacerbation of acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, seizures, tremors, paresthesia, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, increased LDH, elevated ALP, increased total bilirubin, loss of appetite, jaundice, dark urine, pruritus, abdominal tenderness, elevated serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, weakness, elevated CPK, elevated serum myoglobin, increased urinary myoglobin, stomatitis, mucositis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, dysgeusia, hearing loss, paresthesia, arthralgia, myalgia, olfactory disturbances, tinnitus, auditory impairment, hypoglycemia, tinnitus, hearing impairment, vomiting, nausea, abdominal pain, purpuric rash, acute generalized exanthematous pustulosis, injection site phlebitis, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color

This medication should be stored at room temperature between 1 to 30 degrees Celsius, kept in a dark, tightly sealed container to prevent exposure to light. Proper storage maintains the drug's efficacy and prevents deterioration.

Appearance

Yellow oval film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle