Medication info
Carvedilol 12.5 mg Tablet

Carvedilol 12.5 mg Tablet

Prescription medicationTabletOral
Ingredient · strength
Carvedilol›12.5mg / 1 tablet
Manufacturer / importer
Sami Pharmaceuticals Co., Ltd.
Appearance
Reddish-brown round tablets
Packaging
90 tablets (10 tablets/PTP X 9)
Approval status
Active

MFDS item code 201905306 · Approved 2019.07.25 · Insurance code 644004280

Summary

Main use
Treatment of essential hypertension, adjunctive treatment of congestive heart failure, and treatment of chronic stable angina
Who takes it
Adults
Adult dose
Do not increase the dose or discontinue this medicine without your doctor's instructions. 1. Essential hypertension 1) Adults (1) For the first 2 days, administer 12.5 mg of carvedilol orally once daily, then administer 25 mg orally once daily. (2) The usual dose is 25 mg orally once daily for 2 weeks. If a dose increase is needed, increase to 25 mg twice daily. The maximum dose per administration is 25 mg, and the maximum daily dose is 50 mg. 2) Older adults In some older adults, 12.5 mg once daily may be sufficient to produce an adequate effect. However, if the effect is insufficient after 2 weeks of treatment, the dose may be increased. 2. Chronic stable angina 1) For the first 2 days, administer 12.5 mg of this medicine orally twice daily, then administer 25 mg orally twice daily. 2) The usual dose is 25 mg twice daily for 2 weeks. If a dose increase is needed (excluding older adults), the dose may be increased to 50 mg twice daily. 3. Congestive heart failure Before starting treatment with this medicine, the patient's existing standard treatment regimen (conventional treatment for chronic heart failure with an ACE inhibitor, a diuretic, and usually a digitalis preparation) must be stable. Fluid retention should also be minimized before treatment with this medicine is started. 1) The usual initial dose is 3.125 mg of this medicine orally twice daily for 2 weeks. If the patient tolerates this treatment well, increase the dose to 6.25 mg twice daily for 2 weeks, then to 12.5 mg twice daily for 2 weeks, and then to 25 mg twice daily. 2) After taking each dose level for at least 2 weeks, gradually increase the dose to the highest dose the patient can tolerate. 3) The minimum effective dose is 6.25 mg twice daily. The maximum dose is 25 mg twice daily for patients weighing 85 kg or less and 50 mg twice daily for patients weighing more than 85 kg. 4) To control the rate of absorption, it is recommended that this medicine be taken with meals in the morning and evening. Taking it with meals slows the rate of absorption and may reduce the incidence of orthostatic hypotension.

Ingredients

Manufacturer
Sami Pharmaceuticals Co., Ltd.

Efficacy & effects

Treatment of essential hypertension, adjunctive treatment of congestive heart failure, and treatment of chronic stable angina

  • Essential hypertension
  • chronic stable angina
  • congestive heart failure
View approved original text

This medication is used for cardiovascular diseases such as essential hypertension, chronic stable angina, and congestive heart failure. It is particularly utilized as an adjunct treatment to diuretics, digoxin, ACE inhibitors, and other vasodilators, thereby enhancing treatment efficacy. It helps control blood pressure, reduce the workload on the heart, and improve overall cardiovascular health.

How to take

Adult dose

Do not increase the dose or discontinue this medicine without your doctor's instructions. 1. Essential hypertension 1) Adults (1) For the first 2 days, administer 12.5 mg of carvedilol orally once daily, then administer 25 mg orally once daily. (2) The usual dose is 25 mg orally once daily for 2 weeks. If a dose increase is needed, increase to 25 mg twice daily. The maximum dose per administration is 25 mg, and the maximum daily dose is 50 mg. 2) Older adults In some older adults, 12.5 mg once daily may be sufficient to produce an adequate effect. However, if the effect is insufficient after 2 weeks of treatment, the dose may be increased. 2. Chronic stable angina 1) For the first 2 days, administer 12.5 mg of this medicine orally twice daily, then administer 25 mg orally twice daily. 2) The usual dose is 25 mg twice daily for 2 weeks. If a dose increase is needed (excluding older adults), the dose may be increased to 50 mg twice daily. 3. Congestive heart failure Before starting treatment with this medicine, the patient's existing standard treatment regimen (conventional treatment for chronic heart failure with an ACE inhibitor, a diuretic, and usually a digitalis preparation) must be stable. Fluid retention should also be minimized before treatment with this medicine is started. 1) The usual initial dose is 3.125 mg of this medicine orally twice daily for 2 weeks. If the patient tolerates this treatment well, increase the dose to 6.25 mg twice daily for 2 weeks, then to 12.5 mg twice daily for 2 weeks, and then to 25 mg twice daily. 2) After taking each dose level for at least 2 weeks, gradually increase the dose to the highest dose the patient can tolerate. 3) The minimum effective dose is 6.25 mg twice daily. The maximum dose is 25 mg twice daily for patients weighing 85 kg or less and 50 mg twice daily for patients weighing more than 85 kg. 4) To control the rate of absorption, it is recommended that this medicine be taken with meals in the morning and evening. Taking it with meals slows the rate of absorption and may reduce the incidence of orthostatic hypotension.

Precautions

This medication should not be used in certain patients. For example, patients who have had an allergic reaction to this medication or its ingredients, patients with cardiogenic shock, patients with conduction problems in the heart, patients with cor pulmonale, patients with diabetic ketoacidosis, patients with severe heart failure, and patients with asthma or chronic obstructive pulmonary disease are at risk if they take this medication. Additionally, it is advisable for pregnant or breastfeeding women to avoid this medication. Patients with genetic issues such as lactose intolerance should also avoid this medication. This medication should be used with caution in patients with diabetes, the elderly, those with impaired renal or hepatic function, and patients with hypotension. Blood pressure and heart rate should be checked frequently during treatment, and a doctor should be consulted if abnormal symptoms occur. During treatment, side effects such as dizziness, fatigue, headache, decreased heart rate, lowered blood pressure, difficulty breathing, gastrointestinal symptoms, skin rash may occur, so caution is necessary. This medication may interact with other drugs, so if you are taking other medications, you must inform your doctor or pharmacist. Caution is especially important when taken with antihypertensives, antidiabetics, heart medications, antidepressants, tranquilizers, and anesthetics. Suddenly stopping this medication may result in heart issues or blood pressure abnormalities, so it is essential to gradually reduce the dosage under a doctor’s guidance. This medication may discolor when exposed to light, so it should be stored in a light-blocking container and kept out of reach of children.

Side effects

  • Dizziness
  • headache
  • fatigue
  • weakness
  • hallucination
  • confusion
  • depression
  • sleep disorders
  • nightmares
  • psychosis
Show 59 more
  • severe bradycardia
  • shock
  • complete atrioventricular block
  • heart failure
  • cardiac arrest
  • hypotension
  • loss of consciousness
  • decreased pulse rate
  • limb coldness
  • edema
  • apnea
  • renal function deterioration
  • renal failure
  • increased airway resistance
  • nausea
  • diarrhea
  • abdominal pain
  • vomiting
  • constipation
  • urticaria
  • itching
  • lichen planus-like reaction
  • sweating
  • allergic rash
  • serum aminotransferase changes
  • thrombocytopenia
  • leukopenia
  • hypoglycemia
  • concealed hyperthyroidism
  • hyperglycemia
  • weight gain
  • increased serum cholesterol
  • bradycardia
  • hypotension
  • shortness of breath
  • hypertension in angina
  • liver dysfunction
  • jaundice
  • limb pain
  • reduced tear production
  • sensory disturbances
  • visual disturbances
  • eye irritation
  • dry mouth
  • urination disorders
  • sexual dysfunction
  • allergic reactions
  • toxic epidermal necrolysis
  • Stevens-Johnson syndrome
  • blood pressure drop
  • decreased heart rate
  • myocardial depression
  • apnea
  • cardiogenic shock
  • respiratory distress
  • bronchospasm
  • vomiting
  • consciousness disorder
  • generalized seizure

Not everyone experiences these, and they can vary from person to person.

Storage

This medication is sensitive to light and should be stored in a special container that blocks light. Additionally, it is crucial to store it at room temperature, specifically between 1 degree and 30 degrees Celsius, to maintain its effectiveness.

Appearance and packaging

Appearance

Reddish-brown round tablets

Package unit

90 tablets (10 tablets/PTP X 9)

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.