Seroquel Tablet 300 Milligrams (Quetiapine Fumarate)

Adult dose

1. Schizophrenia - Adults: Take this medicine twice daily, with or without food. The total daily dose for the first 4 days is 50 mg on day 1, 100 mg on day 2, 200 mg on day 3, and 300 mg on day 4. From day 4 onward, adjust to the usual effective daily dose of 300～400 mg. The dose may be adjusted within 150～750 mg/day according to the clinical response and tolerability of each patient. - Maintenance therapy has not been evaluated in adult patients with schizophrenia. Patients should be reassessed regularly to determine the need for maintenance therapy. 2. Bipolar disorder (1) Acute treatment of manic episodes associated with bipolar I disorder: - Adults: Take this medicine twice daily, with or without food. As monotherapy or as adjunctive therapy to a mood stabilizer (lithium or valproate), the total daily dose for the first 4 days is 100 mg on day 1, 200 mg on day 2, 300 mg on day 3, and 400 mg on day 4. The total daily dose may be increased to 800 mg by day 6, in increments of no more than 200mg per day. The dose may be adjusted within 200～800 mg/day according to the clinical response and tolerability of each patient; the usual effective daily dose is 400～800 mg. (2) Treatment of depression associated with bipolar disorder: - Adults: Take this medicine once daily at bedtime, with or without food. The total daily dose for the first 4 days should reach 50 mg on day 1, 100 mg on day 2, 200 mg on day 3, and 300 mg on day 4. In confirmatory clinical trials of this medicine, doses of 50 mg on day 1, 100 mg on day 2, 200 mg on day 3, 300 mg on day 4, 400 mg on day 5, and up to 600 mg on day 8 were administered. The recommended daily dose is 300 mg. An antidepressant effect was observed with both 300 mg and 600 mg, but there was no additional benefit at 600 mg. Increases above 300 mg should be initiated by a physician experienced in treating bipolar disorder. Clinical trials indicate that the dose may be reduced to a minimum of 200 mg in patients who tolerate the medicine. (3) Prevention of recurrence of bipolar disorder: - Adults: To prevent recurrence of manic, mixed, or depressive episodes associated with bipolar disorder, patients who responded to quetiapine during acute treatment of bipolar disorder should be maintained on the same dose. The dose may be adjusted within 300～800 mg/day, administered twice daily, according to clinical response and each patient's tolerability. It is important to use the minimum effective dose for maintenance therapy. 3. Elderly patients: As with other antipsychotic drugs, this medicine should be administered with caution to elderly patients, particularly at the start of treatment. Start elderly patients on 25 mg/day of this medicine and gradually increase the dose by 25～50 mg per day. The effective dose in elderly patients may be lower than that in younger patients. 5. Patients with renal or hepatic impairment: Clearance after oral administration of quetiapine is reduced by approximately 25% in patients with renal or hepatic impairment. Quetiapine is primarily metabolized in the liver; therefore, administer with caution to patients with known hepatic impairment. In patients with renal or hepatic impairment, start this medicine at 25 mg/day and gradually increase by 25～50 mg per day to the effective dose.

Child dose

4. Children and adolescents: The safety and efficacy of this medicine have not been established in children and adolescents.

This medication may increase the risk of suicidal thoughts or behaviors in children, adolescents, and young adults with major depressive disorder or other psychiatric conditions, so caution is required during administration. Patients taking this medication may experience elevated blood glucose levels, and those with diabetes or risk factors for diabetes should monitor their blood glucose regularly. Rarely, this medication can cause a severe side effect known as Neuroleptic Malignant Syndrome, characterized by severe muscle rigidity, high fever, and changes in mental status, so patients should notify healthcare professionals immediately if symptoms occur. Long-term use may lead to tardive dyskinesia, which involves abnormal movements, so if any unusual symptoms arise, patients should consult their doctors. In elderly patients with dementia, this medication can increase the risk of death, so extreme caution is necessary. This medication may cause serious blood abnormalities such as severe neutropenia or agranulocytosis, thus requiring regular blood tests to monitor the condition. In patients at risk for cerebrovascular disease, there may be an increased risk of stroke and should be used with caution. There is a risk of venous thrombosis, meaning the formation of blood clots in vessels, so patients with thrombosis risk factors need to be monitored carefully. Patients with cardiovascular disease or hypotension may experience symptoms of blood pressure drops like orthostatic hypotension, requiring careful observation of their conditions. This medication can infrequently cause severe skin reactions, including serious rashes, peeling, fever, so any such symptoms should lead to immediate discontinuation of the drug and consultation with a healthcare provider. This medication should not be administered to patients with specific allergies or hypersensitivity to medications, those in a comatose state, patients concurrently using specific central nervous system depressants, those receiving epinephrine, or patients with diabetes. Patients with impaired liver function should start at lower doses and gradually increase while closely monitoring their status, as the medication may remain in the body for an extended period. Women who are pregnant or may become pregnant, as well as nursing mothers, should use this medication cautiously as it may affect the fetus or newborn. This medication can commonly cause side effects such as drowsiness, dizziness, dry mouth, so caution is required when driving or operating dangerous machinery. Abruptly stopping the medication may lead to withdrawal symptoms, so doses should be reduced gradually. If any unusual behaviors or suicidal tendencies arise during treatment, patients should consult healthcare professionals immediately. This medication may interact with other drugs, so patients should inform their doctor or pharmacist if they are taking other medications. In case of an overdose, severe drowsiness, hypotension, tachycardia may occur, and as there is no specific antidote, appropriate treatment must be obtained immediately from a medical facility. Store out of the reach of children and avoid transferring to other containers.

• Drowsiness
• dizziness
• dry mouth
• withdrawal symptoms
• increased triglyceride levels
• total cholesterol increase
• decreased HDL cholesterol
• weight gain
• decreased hemoglobin
• extrapyramidal symptoms

Store this medication in a tightly sealed container to prevent the entry of air or moisture, preferably in a cool place below 30 degrees Celsius. This will help maintain the effectiveness of the medication for a longer duration.

Appearance

White oblong film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle