Clarithromycin 500 mg (Clarithromycin)

Adult dosage

○ Adults: The usual dose of clarithromycin is 250mg (potency) per dose twice daily. For severe infections, administer 500mg (potency) per dose twice daily. The usual duration of treatment is 7～14 days. For patients with renal failure and creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose twice daily. Do not administer for more than 14 days to these patients. ○ Mycobacterial infections: Administer 500mg (potency) of this medicine per dose twice daily. In this case, it must be administered concomitantly with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine three times daily for 14 days concomitantly with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose three times daily for 14 days (Days 1～14), and omeprazole 40mg once daily for 28 days (Days 1～28).

Children's dosage

○ Children aged 12 years and older: Same as adults ○ Children under 12 years of age: Use clarithromycin oral suspension.

This medication should not be administered to patients allergic to certain components. Patients who have experienced hypersensitivity to clarithromycin or similar class antibiotics should also avoid its use. It can be dangerous when taken with certain medications that may affect heart rhythm, so patients taking these medications should not use this drug. It is considered safe not to administer it to patients with a history of arrhythmias or QT prolongation. Its use is limited in patients with severely impaired liver function or very poor kidney function. Pregnant or breastfeeding women should not take this medication and should consult a professional if necessary. Its use is not recommended in patients with central nervous system infections. This medication contains lactose, so patients with lactose intolerance or genetic lactose metabolism disorders should avoid taking it. Patients with weak liver or kidney function may require dosage adjustments and should take it carefully under medical advice. Long-term or repeated use of this medication may lead to the development of resistant bacteria; thus, it is important to use it only for the necessary duration. If any unusual reactions occur during use, such as allergic symptoms, severe diarrhea, skin rash, or difficulty breathing, immediate discontinuation and consultation with healthcare professionals is required. There are many drug interactions, so patients should inform their healthcare provider of any medications they are taking, and caution is needed when used in combination. Dizziness or confusion may occur when driving or operating machinery, so caution should be exercised. Regular blood tests and liver function tests may be necessary during the course of taking this medication. Overdosage may cause gastrointestinal disturbances or central nervous system abnormalities, so strict adherence to dosage is essential. This medication should be stored under appropriate conditions and taken with particular caution in children and the elderly.

Shock, anaphylactic symptoms, respiratory distress, convulsions, redness, rash, itching, hives, erythema, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral erosions, upper abdominal pain, thirst, tooth discoloration, pancreatitis, increased amylase, dysgeusia, loss of appetite, constipation, fecal discoloration, pseudomembranous colitis, hemorrhagic colitis, fever, cough, eosinophilia, eosinophilic pulmonary infiltrates, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, elevated LDH, increased ALP, elevated total bilirubin, increased serum creatinine, increased BUN, interstitial nephritis, kidney failure, rhabdomyolysis, stomatitis, oral mucositis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, taste disturbance, hearing loss, dysesthesia, arthralgia, myalgia, olfactory disturbances, auditory disturbances, hypoglycemia, tinnitus, hearing impairment, vomiting, purpuric rash, acute generalized rash with pustules, muscle cramps, musculoskeletal rigidity, myopathy, increased serum creatinine, elevated blood urea, nephritis, venous inflammation at the injection site, pain at the injection site, inflammation at the injection site, fever, muscle weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, increased serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased INR, prolonged prothrombin time, abnormal urine color

This medication is sensitive to light, so it should be stored in a dark, airtight container. Additionally, to maintain the medication's efficacy, it is important to store it at room temperature, between 15 to 30 degrees Celsius.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 200 tablets/bottle