Cramax Tablet 625 mg (Amoxicillin-Clavulanate Potassium (4:1))

Adult dose

For adults and children aged 12 years or older or weighing over 40 kg, the recommended dosage is 250 mg/125 mg of amoxicillin/clavulanate potassium taken orally every 8 hours, three times a day. In cases of severe or respiratory infections, the dosage may be increased to 500 mg/125 mg at a time. In patients with renal impairment, the dosage should be adjusted according to creatinine clearance.

Child dose

Same as adults and for children aged 12 years or older or weighing over 40 kg, with dosage adjustment in cases of renal impairment.

This drug should not be administered to patients with hypersensitivity to penicillin-type drugs, as it is a beta-lactam antibiotic. Precautions are necessary for patients with infectious mononucleosis or lymphocytic leukemia due to the increased risk of rash. It should also be avoided in patients with liver dysfunction or a history of liver disease caused by this drug or penicillin. In patients with impaired liver function or moderate to severe renal impairment, dosage and administration intervals should be adjusted to prevent increased drug levels. Patients with allergic tendencies or frequent episodes of bronchial asthma, skin rashes, and those with gastrointestinal symptoms such as vomiting or diarrhea should use this drug cautiously. Gastrointestinal side effects such as diarrhea, abdominal pain, and vomiting may occur, and in severe cases, pseudomembranous colitis or intestinal hemorrhage may develop; if symptoms arise, discontinue use immediately. Abnormal liver function symptoms have also been reported, so regular liver function tests are required for the elderly or those on long-term therapy. Serious allergic reactions such as skin rash, urticaria, and anaphylaxis may occur rarely, so if unusual symptoms arise, drug administration should be stopped immediately, and medical attention sought. Various abnormal reactions such as hematological abnormalities, renal dysfunction, and central nervous system symptoms have also been reported, necessitating careful observation of the patient's condition. This drug may interact with other medications, so it is essential to inform healthcare professionals of any ongoing medications, particularly when used with anticoagulants, probenecid, or allopurinol. Women who are pregnant or breastfeeding should carefully consider the use, and breastfeeding mothers should monitor for side effects in the infant. It is not recommended for children under 12 years of age or weighing less than 40 kg. Elderly patients are at increased risk of side effects due to renal and liver function decline, so dosage adjustments and status monitoring are essential. In case of overdose, gastrointestinal symptoms, central nervous system abnormalities, or allergic reactions may occur, necessitating immediate medical attention. This drug should be stored in a special container to prevent moisture, in a cool, dry place at or below 25°C to maintain its effectiveness for an extended period.

Serious side effects

Urticaria, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweats, pallor, anaphylaxis, severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, bullous exfoliative dermatitis), angioedema, symptoms of hypotension, acute pancreatitis, pseudomembranous colitis, hemorrhagic colitis, severe colitis with blood in stools, severe rash, blisters, skin peeling, pain in mucous membranes of the mouth/eyes, respiratory difficulty, asthma attacks, bronchospasm

Mild side effects

Diarrhea, dyspepsia, stomatitis, gastritis, glossitis, nausea, vomiting, anorexia, abdominal pain, bloating, constipation, colonic discomfort, acid reflux, soft stools, dry mouth, candidiasis, colitis without blood in stools, increased AST, ALT, ALP, LDH, serum bilirubin, hepatitis, skin itching, erythema multiforme, hematological abnormalities (reversible leukopenia, thrombocytopenia, anemia, etc.), vaginal itching, increased secretion, anxiety

This drug should be stored in a special container to prevent moisture, ideally in a cool and dry place, at or below 25°C. Proper storage will help maintain the medication's effectiveness over time.

Appearance

White or nearly white oblong film-coated tablet

Package unit

60 tablets/PTP (4 tablets x 15)