Clarithromycin 500mg Tablet

Adult dosage

○ Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7～14 days. In patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or 250mg (potency) twice daily for severe infections. Do not administer for more than 14 days in these patients. ○ Mycobacterial infections: Administer 500mg (potency) of this drug twice daily. In this case, it must be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, or rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this drug three times daily in combination with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) three times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

Children 12 years of age and older: Same as adults Children under 12 years of age: Use clarithromycin dry syrup.

This medication should not be used in individuals allergic to specific additives or patients who have had hypersensitivity reactions to similar classes of antibiotics. Co-administration with certain medications that may affect the heart can increase the risk of heart rhythm abnormalities, so patients taking such medications should not use this drug. Patients with severely impaired liver or kidney function, pregnant or breastfeeding women, and patients with infections of the central nervous system should not be administered this medication for safety. This medication contains lactose and should not be administered to patients with lactose intolerance or related genetic disorders. Patients with weakened liver or kidney function, heart diseases, elderly patients, and patients taking other antibiotics should use this medication cautiously. If any allergic reactions or severe side effects occur while taking this medication, it should be discontinued immediately and medical attention sought. Various side effects may present in several organs such as the digestive system, skin, nervous system, liver, and kidneys, so any unusual symptoms should be quickly consulted with medical professionals. This drug has many interactions with other medications, and patients must inform their healthcare providers about any other medications they are taking to carefully monitor changes in drug concentrations or risks of side effects. It is safer to avoid using this medication during pregnancy or lactation, and breastfeeding should be discontinued if necessary. Special attention is needed for children and elderly patients, carefully considering dosage adjustments or whether to administer it. Overdosage may lead to gastrointestinal disturbances or neurological anomalies, so it is vital to adhere strictly to the prescribed dosage, and immediate hospital visit is necessary in case of overdose. This medication should be stored at room temperature, avoiding refrigeration, and should be protected from direct sunlight.

Shock, anaphylactic symptoms, respiratory distress, convulsions, redness, rash, itching, hives, erythema, joint swelling, drug rash, abdominal bloating, nausea, vomiting, dyspepsia, abdominal pain, discomfort, flatulence, diarrhea, oral mucosal ulceration, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disturbance, loss of appetite, constipation, discoloration of stool, pseudomembranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic pulmonary infiltration, interstitial pneumonia, chronic bronchitis, exacerbation of acute maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremor, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, taste distortion, hearing loss, paresthesia, arthralgia, myalgia, olfactory impairment, hypoglycemia, tinnitus, hearing disability, purpuric rash, acute generalized pustular exanthem, muscle cramps, musculoskeletal stiffness, myopathy, venous thrombophlebitis at injection site, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color, decreased appetite, insomnia, anxiety, nervousness, loud noise, psychotic disorders, confusional state, depersonalization, depression, disorientation, hallucinations, abnormal dreams, mania, taste disturbance, headache, loss of consciousness, movement disorders, non-vestibular vertigo, drowsiness, tremor, convulsions, loss of taste, abnormal olfaction, loss of smell, vestibular vertigo, hearing impairment, deafness, cardiac arrest, atrial fibrillation, QT prolongation on electrocardiogram, extrasystole, palpitations, vasodilation, asthma, nasal bleeding, pulmonary embolism, diarrhea, vomiting, dyspepsia, nausea, abdominal pain, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, stomatitis, glossitis, abdominal bloating, constipation, thirst, belching, distention, acute pancreatitis, tongue discoloration, tooth discoloration, abnormal liver function tests, cholestasis, hepatitis, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyltransferase, liver failure, hepatocellular jaundice, rash, hyperhidrosis, vesicular dermatitis, itching, hives, papular rash, acne, Henoch-Schonlein purpura, myalgia, rhabdomyolysis, myopathy, renal failure, nephritis, venous thrombophlebitis at injection site, injection site pain, injection site inflammation, malaise, fever, weakness, chest pain, chills, fatigue

This medication is sensitive to light, so it should be stored in a container that does not allow light in. Additionally, it is advisable to store the medication at room temperature between 15 to 30 degrees Celsius. Following these storage conditions will help maintain the efficacy of the medication over time.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle