Megarevofloxacin Tablet 500 mg (Levofloxacin Hydrate)

Adult dose

Generally, for adults, 250–750 mg of levofloxacin is administered orally once daily. 1. For patients with normal renal function: - Complicated skin and soft tissue infections: 750 mg once every 24 hours for 10–14 days. - Community-acquired pneumonia: 500 mg once every 24 hours for 7 days. - Acute bacterial exacerbation of chronic bronchitis: 7 days. - Acute sinusitis: 10–14 days. - Chronic bacterial prostatitis: 28 days. - Complicated urinary tract infections including mild to moderate acute pyelonephritis: 250 mg once every 24 hours for 10 days. - Uncomplicated urinary tract infections of mild to moderate severity: 3 days.

This drug is an antibiotic used to treat specific bacterial infections. Caution is necessary when taking this medication as serious side effects such as tendonitis, tendon rupture, peripheral neuropathy, central nervous system disturbances, and exacerbation of severe myasthenia gravis may occur. Patients with a history of severe myasthenia gravis should avoid using this medication as their symptoms may worsen. Furthermore, this drug should be used only when no other treatment options are available for specific infections such as acute bacterial rhinosinusitis, acute exacerbation of chronic bronchitis, uncomplicated urinary tract infections, and acute otitis media. Older adults, patients with impaired renal function, organ transplant recipients, and those taking corticosteroids may have an increased risk of tendon rupture; thus, co-administration should be avoided. If pain or inflammation occurs in the shoulder, hands, or Achilles tendon while using this medication, discontinue use immediately and rest. Patients with severe myasthenia gravis should be particularly cautious as the neuromuscular blocking effects of this medicine may worsen their symptoms. Patients with hypersensitivity to this drug or a history of tendonitis or tendon rupture, youths under 18 years of age, pregnant or nursing women, and patients with epilepsy should not use this medication. Patients with severely impaired renal function, central nervous system disorders, a history of seizures, those taking certain anti-inflammatory drugs or theophylline, diabetic patients, patients with specific genetic disorders, and those with a history of aneurysm or heart valve disease should use this medication with caution. This drug can cause a range of side effects, including severe allergic reactions, psychiatric disturbances, heart rhythm irregularities, kidney and liver dysfunction, blood disorders, digestive issues, muscle and tendon disorders, and skin reactions; thus, if any unusual symptoms occur, consulting a healthcare professional immediately is essential. When taking this drug, avoid strong sunlight or artificial UV exposure, and be cautious of dizziness or drowsiness when driving or operating machinery. Additionally, this medication may interact with other drugs, particularly antacids, iron supplements, calcium supplements, hypoglycemic agents, and anticoagulants; therefore, inform healthcare providers and manage these interactions carefully. Pregnant or nursing women should not take this drug, and especially if nursing, they should cease breastfeeding. This drug has not been established as safe for use in children and adolescents during growth. Older adults should be cautious regarding dosages due to the longer retention of the drug in the body resulting from decreased renal function, increasing the risk of side effects; thus, dosage and administration intervals should be adjusted carefully. In cases of overdose, symptoms like central nervous system disturbances and heart rhythm irregularities may occur, requiring immediate medical attention, as this drug is not removed by hemodialysis. If any unusual symptoms occur while taking this medication, it is crucial to stop taking it and consult a healthcare provider immediately.

Serious side effects

• Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor → severe allergic reactions
• Severe rash, blisters, skin peeling, mucosal pain in mouth/eyes → severe skin adverse reactions
• Difficulty breathing, asthma attack, respiratory issues accompanied by cough and fever → respiratory problems
• Yellowing of skin or eyes (jaundice), extreme lethargy across the body → liver issues (jaundice)
• Sudden and severe headache, lightning-like headache

Mild side effects

Insomnia, dizziness, headache, tremors, anxiety, depression, psychiatric reactions (hallucinations, paranoia, irritability, delirium, disorientation, attentional impairment, nightmares), restlessness, confusion, visual and auditory disturbances, taste and smell disorders, tinnitus, sensory disturbances, sensory loss, asthenia, palpitations, QT interval prolongation, arrhythmias, elevated BUN and serum creatinine, nausea, vomiting, abdominal discomfort, diarrhea, loss of appetite, abdominal pain, abdominal bloating

Store this medication in a tightly closed container to prevent air or moisture from entering, ideally at room temperature between 1 and 30 degrees Celsius.

Appearance

Peach-colored rectangular film-coated tablet

Package unit

28 tablets/bottle, 100 tablets/bottle