Medication info

Zepirus Inhalation Capsule 150/25 Micrograms

Prescription medicationHard capsuleApproval withdrawn
Ingredient · strength
Budesonide›150μg / 1 capsuleSalmeterol Xinafoate Micronized›25μg / 1 capsule
Manufacturer / importer
(주)휴온스
Appearance
Colorless transparent inhalation hard capsules containing white powder (attached to the inhaler called Axahaler)
Packaging
60 capsules/bottle, 120 capsules/bottle, 180 capsules/bottle
Approval status
Approval withdrawn

MFDS item code 201902958 · Approved 2019.05.08

This product's status changed to Approval withdrawn on 2025.04.25. It may no longer be sold, so consult a doctor or pharmacist before taking it.

Summary

Main use
Improvement of asthma symptoms and inflammation suppression treatment
Who uses it
Adults
Adult dosage
The usual dose is to inhale 150/25 μg twice daily, or 300/25 μg twice daily.

Ingredients

Importer
(주)휴온스

Efficacy & effects

Improvement of asthma symptoms and inflammation suppression treatment

  • Asthma
View approved original text

This medication is used to effectively control symptoms in adult asthma patients and improve respiratory function by combining a long-acting beta 2 agonist with an inhaled corticosteroid. The combination therapy helps better manage asthma symptoms and aids in reducing the frequency and severity of asthma attacks. Therefore, this treatment plays a significant role in improving the quality of life for asthma patients.

Dosage and Administration

Adult dosage

The usual dose is to inhale 150/25 μg twice daily, or 300/25 μg twice daily.

Precautions

This medicine should not be used in patients with severe exacerbations of asthma or acute asthma attacks. Patients who are allergic to this drug or its ingredients should not take it. Since it contains lactose, it is contraindicated in patients with lactose intolerance or related genetic disorders. Patients with severe cardiovascular disease or hyperthyroidism should use this drug cautiously. Diabetic patients should manage their blood sugar levels properly, as it may increase blood glucose. Patients with hypokalemia should monitor their potassium levels closely when using this drug. If there is a respiratory infection or paradoxical bronchospasm occurs, treatment should be sought immediately, and drug use should be discontinued. Patients with a history of systemic steroid use causing adrenal dysfunction should also be careful. This drug may cause side effects such as bronchitis, oral candidiasis, tremor, headache, palpitations, voice disorders, and others. It is especially important to rinse the mouth thoroughly after inhalation, as hoarseness or oral and throat candidiasis may occur. Very rarely, severe bronchospasm or cardiovascular side effects may occur, so any unusual symptoms should be reported to a doctor immediately. After asthma symptoms are controlled, it is recommended to gradually reduce to the minimum effective dose; sudden discontinuation may worsen symptoms, so it should be reduced progressively according to a physician's instructions. This drug may interact with other medications; caution is particularly needed when used with CYP3A4 inhibitors or beta-blockers. If pregnant or breastfeeding, the use of this drug should only be decided after careful consultation with a doctor if deemed necessary. It is important to clean the inhaler properly and to follow the usage instructions accurately, rinsing the mouth afterwards to reduce the risk of infection. This drug should be stored in a tightly sealed container to avoid exposure to air or moisture. The storage temperature should be maintained between 1 and 30 degrees Celsius. Proper storage like this can help maintain the drug's effectiveness and safety.

Side effects and when to seek care immediately

Serious side effects

  • Hives
  • severe swelling (angioedema)
  • chest tightness
  • difficulty breathing
  • cold sweat
  • pallor
  • severe rash with fever
  • blistering
  • skin peeling
  • pain in mucous membranes of mouth/eyes
Show 12 more
  • anaphylactic reaction
  • difficulty breathing
  • bronchospasm
  • paradoxical bronchospasm
  • yellowing of skin or eyes (jaundice)
  • sudden and very severe headache
  • seizures
  • confusion
  • vision changes
  • paralysis
  • significantly reduced urine output
  • severe swelling throughout the body.

Mild side effects

  • Bronchitis
  • candidiasis
  • oral candidiasis
  • hypokalemia
  • tremor
  • headache
  • palpitations
  • voice disorders
  • bacterial imbalance
  • increased appetite
Show 25 more
  • nervousness
  • nightmares
  • dizziness
  • instability
  • anxiety
  • neuroexcitability
  • sleep disturbances
  • blurred vision
  • cataracts
  • glaucoma
  • nasopharyngitis
  • hoarseness
  • sinusitis
  • cough
  • pharyngeal irritation
  • difficulty swallowing
  • nausea
  • bruising
  • swelling
  • itching
  • dermatitis
  • urticaria
  • traumatic fractures
  • muscle cramps
  • fatigue

Not everyone experiences these, and they can vary from person to person.

Storage

This drug must be stored in a tightly sealed container to prevent exposure to air or moisture. It is important to maintain a storage temperature between 1 and 30 degrees Celsius. This will help preserve the drug's efficacy and safety.

Appearance and packaging

Appearance

Colorless transparent inhalation hard capsules containing white powder (attached to the inhaler called Axahaler)

Package unit

60 capsules/bottle, 120 capsules/bottle, 180 capsules/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.