Seoul Febuxostat 40 Milligrams

Adult dosage

Administer 40 mg or 80 mg once daily. Recheck the serum uric acid concentration after 2 weeks. The treatment goal is to lower and maintain the serum uric acid concentration below 6 mg/dL (357 μmol/L). No dose adjustment is necessary in patients with mild or moderate renal impairment. The safety and efficacy of this medicine have not been adequately evaluated in patients with severe renal impairment (creatinine clearance less than 30mL/min). No special dose adjustment is necessary in patients with mild or moderate hepatic impairment. Limited information is available for patients with moderate hepatic impairment, and the efficacy and safety of this medicine have not been studied in patients with severe hepatic impairment (Child-Pugh Class C).

This drug may increase the risk of cardiovascular mortality when administered to patients with cardiovascular diseases, so it should be used cautiously in patients with a history of cardiovascular disease. Patients with allergies to the main ingredient or excipients of this drug, those taking the specific medications mercaptopurine or azathioprine, and patients with hereditary diseases such as lactose intolerance should not use this medication. Patients with liver disease or changes in thyroid function, heart disease or heart failure patients, and those on specific drug combinations should use this medication with caution. Various side effects such as liver function abnormalities, diarrhea, headache, rash, fatigue, myalgia, dizziness, etc., may occur during treatment; therefore, any unusual symptoms should be reported to a healthcare provider immediately. In cases of acute gout attacks, the initiation of this medication should be avoided, and it is recommended to continue with other medications for a certain period to prevent gout attacks. Drowsiness or dizziness may occur during treatment, so it is advisable to avoid hazardous activities such as driving or machine operation. It is preferable for pregnant or nursing women not to take this medication, and there is no experience in administering this drug to children under 18 years of age, so it should not be given. This medication can interact with other drugs, so if you are taking any other medications, be sure to inform your healthcare provider, especially that it should not be combined with mercaptopurine or azathioprine. Before and during treatment, liver function tests should be performed regularly, and if symptoms of liver function decline appear, the medication should be discontinued immediately and medical attention should be sought. This drug should be kept out of reach of children and does not require special storage conditions.

Liver dysfunction, dizziness, diarrhea, headache, rash, nausea, fatigue, joint pain, limb pain, gout, myalgia, pruritus, respiratory difficulty, anemia, idiopathic thrombocytopenic purpura, leukocytosis, leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia, angina, atrial fibrillation, atrial flutter, heart murmur, electrocardiogram abnormalities, palpitations, bradycardia, tachycardia, hearing loss, tinnitus, vertigo, blurred vision, abdominal distension, abdominal pain, constipation, dry mouth, dyspepsia, flatulence, increased bowel frequency, gastritis, gastroesophageal reflux disease, gastrointestinal discomfort, gum pain, hematemesis, hyperchlorhydria, melena, oral ulcer, pancreatitis, gastric ulcer, vomiting, asthenia, chest pain, chest discomfort, edema, emotional disturbance, gait disturbance, influenza-like symptoms, mass, pain, thirst, cholelithiasis, diabetes mellitus, hepatic steatosis, hepatitis, hepatomegaly, hypersensitivity, herpes zoster, anorexia, appetite decrease, appetite increase, dehydration, diabetes, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, hypokalemia, weight loss, weight gain, arthritis, joint stiffness, joint swelling, muscle cramp, muscle fasciculation, muscle tightness, muscle weakness, musculoskeletal pain, muscle rigidity, taste changes, balance abnormalities, cerebrovascular accident, Guillain-Barré syndrome, headache, hemiparesis, sensory loss, olfactory decline, cerebral infarction, drowsiness, mental disorder, migraine, sensory abnormalities, sleepiness, transient ischemic attack, tremors, agitation, anxiety, depression, insomnia, excitability, decreased libido, neurological irritability, panic attack, personality change, hematuria, nephrolithiasis, pollakiuria, proteinuria, renal failure, kidney dysfunction, urinary urgency, urinary incontinence, mastalgia, erectile dysfunction, gynecomastia, bronchitis, cough, dyspnea, epistaxis, nasal dryness, excessive nasal secretions, pharyngeal edema, airway congestion, sneezing, throat irritation, upper respiratory infection, alopecia, angioedema, dermatitis, skin rash, petechiae, eczema, hair discoloration, hair growth abnormalities, hyperhidrosis, skin peeling, petechial hemorrhage, photosensitivity, pruritus, purpura, skin discoloration, pigmentary changes, skin lesions, axillary hyperhidrosis, urticaria, flushing, facial flushing, hypertension, hypotension, activated partial thromboplastin time prolongation, creatinine increase, bicarbonate decrease, sodium increase, EEG abnormalities, glucose increase, cholesterol increase, triglyceride increase, amylase increase, potassium increase, thyroid-stimulating hormone increase, platelet decrease, hematocrit decrease, hemoglobin decrease, MCV increase, erythrocyte decrease, creatinine increase, blood urea increase, blood urea nitrogen to creatinine ratio increase, CPK increase, ALP increase, LDH increase, PSA increase, urinary output increase, urinary output decrease, lymphocyte count decrease, neutrophil count decrease, leukocyte count increase, leukocyte count decrease, coagulation test abnormalities, LDL increase, prothrombin time prolongation, urinary casts, positive urinary leukocytes, positive urinary protein, contusion, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute anaphylactic reaction, shock, liver failure, jaundice, liver dysfunction, agranulocytosis, rhabdomyolysis

This medication should be stored in a tightly sealed container to protect it from air and moisture. The best storage temperature is at room temperature, ideally between 1 to 30 degrees Celsius.

Appearance

White to yellowish round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle