Clopidogrel 75 mg (Clopidogrel Sulfate)

Adult dose

For patients with ischemic stroke, myocardial infarction, or peripheral artery disease, 75 mg should be taken orally once daily as clopidogrel. For acute coronary syndrome patients (unstable angina or non-ST elevation myocardial infarction), starting with a loading dose of 300 mg orally once daily on the day of initiation and maintain a dosage of 75 mg orally once daily thereafter. During this time, aspirin 75-325 mg should also be co-administered once daily.

This medication is an antiplatelet agent that prevents platelets from aggregating to form clots. There may be an increased risk of bleeding while taking this medication, and it may take longer for bleeding to stop. Any bleeding that does not stop or any prolonged bleeding should be reported to a doctor immediately. In particular, patients with genetically decreased activity of the CYP2C19 enzyme may experience reduced efficacy of this medication; therefore, treatment methods may need to be adjusted or alternative medications considered. Additionally, co-administration with drugs that activate the CYP2C19 enzyme can increase the concentration of this medication, thereby increasing the risk of bleeding, so co-administration should be avoided. Patients with allergies to this medication, severe bleeding conditions, severe liver impairment, nursing mothers, and those with certain genetic lactose intolerances should not take this medication. Patients at high risk of bleeding or scheduled for surgery must consult a doctor before taking this medication, and may need to discontinue use 5 to 7 days prior to surgery. Care should also be taken when co-administering this medication with aspirin or other drugs that increase the risk of bleeding. During treatment with this medication, regular monitoring through blood tests or other means to check for bleeding or blood abnormalities is required. Rarely, this medication can cause serious thrombocytopenia or blood disorders, so if fever or signs of infection occur, the doctor should be informed immediately. Gastrointestinal symptoms may include abdominal pain, dyspepsia, diarrhea, and allergic reactions such as skin rashes or itching have also been reported. Elderly patients or those with impaired renal or liver function are at increased risk of bleeding and should use this medication with caution, as dose adjustments or monitoring may be necessary. Pregnant women are advised to discontinue use before delivery, as there may be an increased risk of bleeding. Nursing mothers should consult their doctor regarding whether to continue breastfeeding or discontinue use, as this medication may be secreted in breast milk. Overdose may further increase the risk of bleeding and since there is no specific antidote, platelet transfusion or other treatment may be necessary if there is severe bleeding. The safety and efficacy of this medication in children have not been established, so caution is advised when using it. Before starting or stopping any new medications during the use of this medication, it is essential to consult with a doctor or pharmacist, especially if co-administering with other drugs that increase the risk of bleeding.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, painful mucous membranes in the mouth/eyes, difficulty breathing or shortness of breath, asthma attacks, respiratory abnormalities associated with cough and fever, yellowing of skin or eyes (jaundice), extreme fatigue, sudden and severe headache, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, urination

Mild side effects

• Headache
• dizziness
• abdominal pain
• dyspepsia
• diarrhea
• nausea
• rash
• itching
• petechiae/bruising
• nosebleeds

This medication should be stored in a tightly closed container to protect it from air and moisture. It is best to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle