Alisert Tablet 5 mg (Donepezil Hydrochloride Hydrate)

Adult dosage

As Donepezil Hydrochloride, administer 5 mg once daily before bedtime. If unusual dreams, nightmares, or sleep disturbances occur, consider morning administration. Donepezil concentration reaches steady state 15 days after administration, thus administer 5 mg for 4 to 6 weeks, and thereafter, evaluate clinical response for possible dose escalation up to 10 mg. When increasing to 10 mg per day, be cautious of gastrointestinal adverse reactions.

Children's dosage

No experience in pediatric use.

This medication contains Donepezil Hydrochloride as the active ingredient and is used for the treatment of Alzheimer's-type dementia. First, this medication should not be administered to patients allergic to Donepezil Hydrochloride, piperidine derivatives, or any ingredients in this product. It is also advisable for pregnant women, women who may become pregnant, and breastfeeding women to avoid using this medication. Furthermore, this medication is not suitable for patients with lactose intolerance or certain genetic conditions. Caution should be exercised in patients with heart disease or cardiac conduction disorders, as this medication may induce bradycardia or arrhythmia. Patients taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcer disease should be careful, as gastrointestinal conditions may worsen. Patients with a history of asthma or obstructive pulmonary disease should also be cautious, as this medication may exacerbate respiratory symptoms. Patients with extrapyramidal disorders, such as Parkinson's disease, may experience worsening symptoms with this medication. This medication can cause side effects such as nausea, vomiting, diarrhea, loss of appetite, dizziness, insomnia, and in severe cases, heart problems, liver dysfunction, cerebrovascular accidents, and muscle-related symptoms. If serious symptoms occur, immediate consultation with a physician is required. Additionally, this medication may affect heart rhythms, so patients with heart disease or a history of QT prolongation may require ECG testing. This medication may affect driving or machinery operation capabilities, thus caution is needed during the initial dosage or changes in dosage. When taken in combination with other medications, interactions may occur, so special caution is needed when taken with medications that affect CYP3A4 and CYP2D6 enzymes. It is safer for pregnant or breastfeeding women to avoid this medication, and if necessary, consultation with a healthcare professional is recommended. The safety of this medication in children has not been established, so it should not be used in pediatric patients. In cases of overdose, severe symptoms such as nausea, vomiting, bradycardia, and respiratory depression may occur, requiring immediate emergency treatment, with atropine being a potential antidote. Store this medication in a sealed container to prevent exposure to air and moisture. It is recommended to store it at room temperature between 1 and 30 degrees Celsius to maintain the efficacy of the medication.

Serious side effects

Hives, severe swelling (edema), tightness in the chest, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, peeling skin, pain in mucous membranes of mouth/eyes, shortness of breath or difficulty breathing, asthma attack, respiratory distress with coughing and fever, jaundice (yellowing of skin or eyes), severe fatigue throughout the body, sudden and severe headache, lightning headache, seizures, confusion of consciousness, vision abnormalities, paralysis, urination.

Mild side effects

• Loss of appetite
• insomnia
• drowsiness
• dizziness
• headache
• fatigue
• pain
• nausea
• vomiting
• diarrhea

Store this medication in a sealed container to prevent exposure to air and moisture. It is recommended to keep it at room temperature between 1 and 30 degrees Celsius. This will help maintain the effectiveness of the medication.

Appearance

This medication is a white, round film-coated tablet.

Package unit

30 tablets/bottle