Entacapone 200 mg (Entacapone)

Adult dose

This medication is administered orally at the same time as each dose of levodopa/dopa decarboxylase inhibitor (benserazide or carbidopa). This medication may be used with standard levodopa formulations. Its efficacy as an adjunct to sustained-release levodopa/dopa decarboxylase inhibitor formulations has not been established. This medication may be administered with or without food. Administer 1 tablet of this medication 200mg with each dose of levodopa/dopa decarboxylase inhibitor. The maximum recommended dose of this medication is 1 dose of 200mg 10 times daily, or 2000mg. This medication enhances the efficacy of levodopa. Therefore, to reduce levodopa-related dopaminergic adverse effects, such as dyskinesia, nausea, vomiting, and hallucinations, it may occasionally be necessary to adjust the levodopa dose during the first 1 day to 1 week after starting this medication. The daily levodopa dose should be reduced by approximately 10 ~ 30% by extending the dosing interval or reducing the dose per administration, depending on the patient's clinical condition. If this medication is discontinued, it may be necessary to adjust the doses of other antiparkinsonian medications, particularly levodopa, to control Parkinson's symptoms. This medication slightly increases the bioavailability of levodopa in standard levodopa/benserazide formulations (5-10%) more than the bioavailability of levodopa in standard levodopa/carbidopa formulations. Therefore, patients receiving standard levodopa/benserazide formulations may require a greater reduction in the levodopa dose when starting this medication. Renal impairment does not affect the pharmacokinetics of this medication; therefore, no dose adjustment is necessary. However, extending the dosing interval may be considered in patients receiving dialysis. Elderly patients: No dose adjustment of this medication is required for elderly patients.

Child dose

Studies have not been conducted in patients aged 18 years or younger; therefore, use in patients in this age group is not recommended.

This medication should not be used by patients who are allergic to the active ingredient or other components. Women who are pregnant or breastfeeding should not take this medication. Patients with liver function problems should not use this medication. There is a risk of serious hypertensive crisis when administered to patients with specific types of tumors called pheochromocytoma. It may be risky to use in combination with some antidepressants or certain enzyme inhibitors, so it should never be co-administered. Patients with a history of neuroleptic malignant syndrome or rhabdomyolysis should not take this medication. This medication contains lactose, so patients with lactose intolerance or related genetic disorders should avoid it. In the initial period of use, side effects related to increased dopamine action, such as movement disorders, may frequently occur, and gastrointestinal disturbances such as nausea, vomiting, abdominal pain, constipation, and diarrhea are also common. Side effects are generally mild to moderate, and discontinuation of the medication often leads to improvement of symptoms. The frequency of side effects may be higher with high doses. Taking this medication may cause urine to turn reddish-brown, but this is a non-harmful phenomenon. Long-term use may lead to a slight decrease in hemoglobin levels in the blood, necessitating periodic monitoring. Liver function test values may rarely increase, so the liver's health status should be monitored. This medication may cause drowsiness or sudden sleep symptoms due to dopamine action when used in conjunction with other Parkinson's disease treatments, and caution is needed when driving or operating machinery. Especially, it can cause a drop in blood pressure, so patients with orthostatic hypotension should be careful. There may be possible interactions with other medications taken with this medication, so it is essential to inform healthcare providers about the medications being used. Women who are pregnant or breastfeeding should not take this medication, and safety in pediatric patients under 18 years of age has not been established, so it is not recommended. In the case of overdose, confusion, drowsiness, muscle relaxation, and skin reactions may occur, and immediate medical attention should be sought. During the use of this medication, unusual physical symptoms or behavioral changes such as impulse control disorders may appear, so both patients and caregivers should observe closely. If abnormal symptoms occur, it is important to consult with healthcare professionals to adjust the treatment plan.

Movement disorders, nausea, diarrhea, abdominal pain, thirst, constipation, vomiting, fatigue, increased sweating, headache, insomnia, worsening of Parkinson's disease, hallucinations, dizziness, confusion, muscle rigidity, hyperactivity, tremors, leg cramps, sensory disturbances, urinary disturbances, hyperkinetic syndrome, reduced motor function, vertigo, abnormal gait, nausea, constipation, vertigo, headache, confusion, auditory hallucinations, abdominal pain, dry mouth, indigestion, gastrointestinal disorders, oral sensory disturbances, movement disorders, muscle rigidity, gait disorders, on-off phenomenon, sensory disturbances, worsening of Parkinson's disease, depression, sleep disorders, back pain, musculoskeletal rigidity, myalgia, distal pain, erythema, pruritus, rash, cataract, blurred vision, abnormal liver function test results, peripheral edema, cataract surgery, hypertension, ischemic heart disease excluding myocardial infarction, myocardial infarction, loss of appetite, colitis, abnormal liver function test values, erythematous rash, papular rash, pruritus, skin discoloration, hair discoloration, beard discoloration, nail discoloration, urine discoloration, fainting, weight loss, drowsiness, sudden sleep symptoms, neuroleptic malignant syndrome, rhabdomyolysis, pathological gambling, increased libido, hypersexuality, confusion, anxiety

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture, and it is best to store it at room temperature between 1 to 30 degrees Celsius. Proper storage helps to maintain the effectiveness of the medication for a longer period.

Appearance

Bright brownish-yellow oval film-coated tablets

Package unit

30 tablets/bottle