Famciclovir Tablet (Famciclovir)

Adult dose

1. Treatment of herpes zoster Adults: Administer famciclovir 250 mg orally 3 times daily for 7 days. It is preferable to start treatment as soon as symptoms appear after infection. 2. Treatment of an initial episode of genital herpes Adults: Administer this drug 250 mg orally 3 times daily for 5 days. It is preferable to start treatment as soon as symptoms appear after infection. 3. Treatment of an acute recurrent episode of genital herpes Adults: Administer this drug 125 mg orally 2 times daily for 5 days. It is preferable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer this drug 250 mg orally 2 times daily. Interrupt treatment periodically every 6～12 months to assess any change in the natural course of the disease. 5. Patients with renal impairment: Since creatinine clearance of this drug is reduced in patients with renal impairment, dosage adjustment should be made with caution. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster and an initial episode of genital herpes: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 250 mg twice daily 10～29 250 mg once daily 2) Treatment of an acute recurrent episode of genital herpes: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 125 mg twice daily 10～29 125 mg once daily 3) Suppression of recurrent genital herpes: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 250 mg twice daily 10～29 125 mg twice daily 4) If only serum creatinine is known, creatinine clearance can be calculated using the following formulas. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment receiving hemodialysis For patients receiving hemodialysis, administration every 48 hours is preferable, taking the dialysis interval into account. A 4-hour hemodialysis session reduces the plasma concentration of this drug by approximately 75%; therefore, administer this drug immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dosage adjustment is required in patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, no specific recommended dose has been established.

This medicine should not be used in patients with allergies to certain ingredients or genetic metabolic disorders such as lactose intolerance. Patients with impaired kidney function should use this medicine with caution, and dosage adjustments may be necessary as needed. While taking this medicine, symptoms such as headache, dizziness, nausea, vomiting, abdominal pain, and diarrhea may occur, and rare side effects such as decreased blood cell counts or skin rashes have been reported. Serious side effects such as liver dysfunction or acute kidney failure may occur, so it is important to periodically monitor liver and kidney function. This medicine does not cure genital herpes, so it is recommended to avoid sexual contact and maintain safe sexual relations even if symptoms occur during treatment. If symptoms such as dizziness or drowsiness occur while taking this medicine, it is safer to avoid driving or operating machinery. Caution should be exercised in patients with severe liver disease, as the effectiveness of this medicine may be reduced. This medicine may interact with other medications, so especially if taken with drugs that affect renal excretion, it is important to consult a physician. Women who are pregnant or breastfeeding should discuss thoroughly with a physician before taking this medicine if necessary. Children under 18 years are not recommended to use this medicine as safety and efficacy have not been established. Generally, elderly patients do not require dosage adjustments, but in cases of decreased kidney function, dosage adjustments should be made. In case of overdose, immediate medical attention should be sought for appropriate treatment, and drug concentration can be reduced through dialysis. This medicine should be stored in a dry, cool place below 30 degrees Celsius and kept out of the reach of children. It is advisable to maintain the original packaging of the medicine, as transferring it to other containers may affect its quality.

• Headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucinations
• palpitations

This medicine should be stored in a sealed container to prevent exposure to air or moisture, and it is recommended to store it in a dry place below 30 degrees Celsius. Storing it this way can help maintain the effectiveness of the medicine for a long time.

Appearance

White round film-coated tablet

Package unit

21 tablets (7 tablets / PTP × 3) - 7 tablets / PTP[*3]