Clarithromycin 250mg (Clarithromycin)

Adult dosage

The usual dose is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7～14 days. In patients with renal failure and creatinine clearance of 30mL/min or less, the dose should be halved: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer for more than 14 days to these patients. Mycobacterial infections: Administer 500mg (potency) of this medicine per dose twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. Helicobacter pylori eradication in patients with duodenal ulcers: Administer 500mg (potency) of this medicine three times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for an additional 14 days. That is, administer clarithromycin 500mg (potency) per dose three times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

Children 12 years of age and older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be administered to patients with certain drugs or conditions. For example, it can be risky for patients who are allergic to any of the ingredients, or have certain heart diseases, liver disorders, or renal impairments. Additionally, pregnant or breastfeeding women should not use this medication, and it should be avoided in patients with central nervous system infections. When taking with other medications, interactions may occur, so it is essential to consult a physician or pharmacist. Caution should be exercised when prescribing this medication to patients with impaired liver or kidney function, elderly patients, or those with heart diseases. There is a risk of resistant bacteria developing when used together with other antibiotics, so administering it for the appropriate duration based on susceptibility tests is crucial. During treatment, allergic reactions or serious side effects may occur, so if any symptoms arise, the administration should be immediately stopped and healthcare professionals should be notified. Especially severe skin rashes, respiratory distress, fever, abdominal pain, and diarrhea require immediate attention. This medication may interact with various other drugs, so if you are taking any other medications, you must inform your healthcare provider. Some medications may need to be avoided or used with caution when combined, such as certain heart disease treatments, statin drugs, some antifungals, and antivirals, which could increase the risk of side effects. In principle, pregnant and breastfeeding women should not use this medication, and if unavoidable, breastfeeding should be stopped. For children, age restrictions apply, so expert guidance must be followed. Elderly patients may require dose adjustments due to potentially high drug concentrations from decreased kidney function. This medication can also affect liver and kidney functions, so regular check-ups are necessary. In cases of overdose, gastrointestinal disturbances or central nervous system abnormalities may occur, requiring immediate medical intervention. Finally, this medication is sensitive to light and moisture, so it should be stored in a sealed container away from direct sunlight and kept in a dry place.

Shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, pruritus, urticaria, skin flushing, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, convulsive form, dry mouth, transitory tooth discoloration, pancreatitis, increased amylase, taste disturbances, anorexia, constipation, fecal discoloration, pseudomembranous colitis, hemorrhagic colitis, hematochezia, fever, cough, chest X-ray abnormalities, eosinophilia, eosinophilic pulmonary infiltrates, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, de-personalization, convulsions, tremors, numbness, behavior changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash with eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, elevated LDH, increased ALP, increased total bilirubin, increased serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, weakness, elevated CPK, increased serum myoglobin, increased urinary myoglobin, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, taste loss, hearing loss, dysesthesia, arthralgia, myalgia, smell disturbances, tinnitus, hearing impairment, hypoglycemia, purpuric rash, acute generalized exanthematous pustulosis, venous thrombophlebitis at injection site, pain at injection site, inflammation at injection site, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, increased serum lactate dehydrogenase, increased INR, prolonged prothrombin time, discoloration of urine

This medication should be stored in a tightly sealed container that blocks light, at room temperature between 15 and 30 degrees Celsius. By doing so, the medication's effectiveness can be maintained, and deterioration can be prevented.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 200 tablets/bottle