Cefsepa 1 Gram (Ceftriaxone Sodium Hydrate)

Adult administration

Ceftriaxone at a dose of 1 to 2 g administered intravenously or intramuscularly once daily. For severe infections or infections with moderately susceptible pathogens, the dose can be increased up to 4 g once daily. For the treatment of gonorrhea, a single intramuscular injection of 250 mg is recommended. To prevent infections before and after surgery, it is advisable to administer 1 to 2 g once, 30 to 90 minutes prior to the surgery. In patients with kidney and liver dysfunction

Child administration

For neonates (up to 14 days old), administer 20 to 50 mg per kg of body weight as a single daily dose, without exceeding 50 mg per kg. For infants and children (from 15 days old to 12 years), administer 20 to

This medication should not be mixed or administered simultaneously with solutions or drugs containing calcium. Especially in neonates, if this medication comes into contact with calcium, it may form a precipitate and cause serious side effects, thus it must not be administered. Patients with allergies to this medication or a history of hypersensitivity to cephalosporins or penicillin antibiotics should not use it. Moreover, neonates with issues related to bilirubin binding, such as those with jaundice, hypoalbuminemia, or acidosis, may be at risk if this medication is given. Those with a past history of drug allergies or individuals prone to allergic symptoms such as asthma, rashes, and urticaria should use this drug cautiously. Patients with severely impaired kidney function may have prolonged blood concentration of this medication, necessitating dosage adjustments. Common side effects upon administration may include eosinophilia, leukopenia, thrombocytopenia, diarrhea, rashes, increased liver enzyme levels, and so on. Rarely, severe allergic reactions, pseudomembranous colitis, interstitial pneumonia, severe skin reactions, and acute renal failure may occur, and symptoms should be reported to healthcare professionals immediately. This medication should be used for the prescribed duration only, determined by susceptibility testing to prevent antibiotic-resistant bacteria, and hypersensitivity should be assessed before administration. During treatment, regular monitoring of liver function, kidney function, and blood tests is essential. There is no specific antidote for overdose, so symptomatic treatment is needed, and if dizziness or similar symptoms occur during the course of treatment, driving or operating machinery should be avoided. Pregnant or nursing individuals should use this medication with caution due to uncertainty regarding its safety, and it should not be administered to neonates or premature infants due to the risk of bilirubin encephalopathy. This medication may interact with other drugs; therefore, special caution is warranted, especially when used with diuretics, aminoglycoside antibiotics, or vitamin K antagonists. It should always be administered separately from calcium-containing solutions and must not share the same injection port.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, breathlessness or difficulty breathing, asthma attacks, respiratory abnormalities with cough and fever, jaundice (yellowing of skin or eyes), extreme lethargy, sudden and severe headaches, thunderclap headaches, seizures, confusion, visual disturbances, paralysis, urination abnormalities

Mild side effects

• Eosinophilia
• leukopenia
• thrombocytopenia
• diarrhea
• rash
• increased liver enzymes
• headaches
• dizziness
• bronchospasm
• loose stools

This medication should be stored in a sealed container to prevent air or moisture exposure, and it is preferably kept at room temperature between 1 to 30 degrees Celsius. Proper storage helps maintain the efficacy of the medication for a longer period.

Appearance

A colorless and transparent vial filled with a white to light yellow crystalline powder.

Package unit

10 vials