Clarithromycin 500mg (Clarithromycin)

Adult dosage

○ Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7～14 days. In patients with renal failure and a creatinine clearance of 30mL/min or less, the dose should be reduced by half. That is, administer 250mg (potency) once daily; for severe infections, administer 250mg (potency) twice daily. Do not administer this medicine to these patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it must be administered in combination with other antimycobacterial agents, such as ethambutol, clofazimine, or rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine three times daily in combination with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for a further 14 days. That is, administer clarithromycin 500mg (potency) three times daily for 14 days (days 1～14) and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

Children aged 12 years and older: Same as adults For children under 12 years, use clarithromycin dry syrup.

This medication should not be used in certain patients. Patients with allergies to any of the ingredients in this medication or a history of hypersensitivity to similar classes of antibiotics should not be administered this medication. Additionally, caution is necessary for patients with certain heart conditions or severely impaired liver or kidney function, as this medication may pose risks. It is safest for pregnant or breastfeeding women to avoid taking this medication. This medication may interact with several other drugs, so if you are taking any other medications, you must inform your doctor or pharmacist. Special caution is needed when used in conjunction with drugs affecting the heart, those metabolized by the liver, and certain anticoagulants and antidiabetics. While taking this medication, allergic reactions, heart irregularities, liver function abnormalities, kidney function decline, gastrointestinal issues, or central nervous system disturbances may occur, so you should notify healthcare professionals immediately if any abnormal symptoms appear. Long-term or high-dose use may lead to hearing loss or tinnitus; if such symptoms arise, consult a doctor and consider discontinuing the medication. Elderly patients or those with reduced liver or kidney function may require dosage adjustments, so they should take the medication according to medical advice. This medication contains lactose, so it is advisable for patients with lactose intolerance not to take it. If you experience persistent diarrhea or abdominal pain while taking this medication, it may indicate serious intestinal disorders like pseudomembranous colitis; in such cases, notify healthcare professionals immediately for appropriate treatment. Lastly, this medication may cause dizziness or confusion that could affect driving or operating machinery, thus caution is advised if such symptoms occur.

Shock, anaphylactic symptoms, shortness of breath, convulsions, redness, rash, itching, hives, skin erythema, angioedema, joint swelling, drug rash, abdominal bloating, nausea, vomiting, dyspepsia, abdominal pain, discomfort, flatulence, diarrhea, oral mucosal ulceration, upper abdominal pain, colicky upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disturbances, anorexia, constipation, discoloration of stool, pseudomembranous colitis, hemorrhagic colitis, abdominal pain, frequent diarrhea, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic pulmonary infiltrate, interstitial pneumonia, chronic bronchitis, exacerbation of acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash accompanied by eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, increased AST, increased ALT, increased γ-GTP, increased LDH, increased ALP, increased total bilirubin, anorexia, jaundice, dark urine, pruritus, abdominal tenderness, elevated serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, malaise, increased CPK, elevated serum myoglobin, elevated urinary myoglobin, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, taste disturbance, hearing loss, paresthesia, arthralgia, myalgia, olfactory disorders, tinnitus, hearing impairment, hypoglycemia, tinnitus, hearing loss, vomiting, purpuric rash, increased amylase, increased AST, increased ALT, increased BUN, thrombocytopenia, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylaxis reaction, angioedema, decreased appetite, insomnia, neurosensitivity, cry of noise, psychotic disorder, confusion state, abnormal dreams, movement disorders, non-vestibular dizziness, drowsiness, tremor, vestibular dizziness, hearing impairment, hearing loss, cardiac arrest, atrial fibrillation, extrasystole, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, abnormal liver function tests, bile duct obstruction, increased alanine aminotransferase, increased aspartate aminotransferase, increased gamma-glutamyltransferase, hepatocellular jaundice, vesicular dermatitis, sweating, papular rash, acne, Henoch-Schonlein purpura, acute generalized rash with pustules, muscle cramps, musculoskeletal stiffness, myopathy, elevated blood urea, nephritis, inflammation of the injection site vein, pain at the injection site, inflammation at the injection site, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, increased serum lactate dehydrogenase, increased INR, prolonged prothrombin time, abnormal urinary color, changes in mental allocation, obsessive behaviors, hypokalemia, hypoxemia

This medication is sensitive to light; therefore, it should be stored in a tightly closed container that blocks light. It is best to keep it at room temperature between 15°C and 30°C.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 200 tablets/bottle