Cephuroxime Tablets (Cefuroxime Axetil)

Adult dose

For optimal absorption, take after meals. 1. Adults and children 12 years and older 1) Most infections Administer 250mg twice daily. 2) Severe lower respiratory tract infections, pneumonia, severe infections, or suspected infections caused by less susceptible organisms Administer 500mg twice daily. 3) Urinary tract infections Administer 250mg twice daily. 4) Uncomplicated gonorrhea Administer 1g as a single dose. 5) Lyme disease Administer 500mg twice daily for 14 days (10~21 days). 3. Patients with renal impairment Cefuroxime is primarily eliminated by the kidneys. To compensate for delayed elimination in patients with significant renal impairment, dose reduction of cefuroxime as described below is recommended. Creatinine clearance ≥ 30 mL/min/1.73m2, T1/2 (hours) 1.4 - 2.4: No dose adjustment required (standard dose: 125mg-500mg twice daily) Creatinine clearance 10 - 29 mL/min/1.73m2, T1/2 (hours) 4.6: Administer the standard single dose every 24 hours Creatinine clearance < 10 mL/min/1.73m2, T1/2 (hours) 16.8: Administer the standard single dose every 48 hours Patients on hemodialysis, T1/2 (hours) 2 - 4: Administer an additional standard single dose at the end of each dialysis session

Child dose

Infants and children under 12 years, most infections: Administer 125mg twice daily. Otitis media in children 2 years and older, severe infections: Administer 250mg twice daily. Infants and children under 12 years, Lyme disease: Administer 250mg twice daily for 14 days (10~21 days). Infants under 3 months: There is insufficient experience with use. For the treatment of infections caused by Streptococcus pyogenes (Group A beta-hemolytic), this medicine should be administered for 7~10 days. As this medicine must not be divided, it is not suitable for treating patients, such as young infants and children, who cannot swallow tablets.

This medication should not be administered to patients with hypersensitivity to cephalosporin antibiotics. It should be used cautiously in patients with a history of allergy to penicillins or other beta-lactam antibiotics. Patients with bronchial asthma, rashes, or urticaria may also need to be cautious due to allergic symptoms. Patients with severely impaired kidney function should be closely monitored when using this medication. Patients who have difficulty with oral intake, those receiving parenteral nutrition, the elderly, or those in poor general condition should be cautious as they may exhibit symptoms of vitamin K deficiency. This medication may lead to excessive growth of Candida and may increase non-sensitive bacteria in the intestines; if unusual symptoms occur, usage should be discontinued. Gastrointestinal disturbances such as diarrhea or abdominal pain may occur; if symptoms persist, medical attention should be sought immediately. In rare cases, serious skin reactions, such as Stevens-Johnson syndrome or toxic epidermal necrolysis, may occur, and administration should be stopped immediately if skin changes occur. This drug may cause dizziness, hence caution is advised while driving or operating machinery. Use of this medication in combination with other diuretics or specific antibiotics may affect kidney function, so caution is advised during concomitant use. Taking this medicine with antacids may reduce its effectiveness, so it is advisable to take it with meals. Women who are pregnant or may become pregnant should carefully consider the risks and benefits before using this drug, and caution is also needed during breastfeeding. It is recommended not to use this medication in infants under 3 months of age, as safety has not been established. Elderly patients should be cautious as adverse reactions can occur more easily due to reduced physiological functions, and dosage and administration intervals should be adjusted accordingly. This drug may affect the results of some clinical tests, so it is important to inform healthcare providers about its use during tests. In cases of overdose, seizures may occur, necessitating immediate medical attention for appropriate treatment. Keep this medication out of reach of children, and it should be stored in its original container for safety.

• Candida overgrowth
• eosinophilia
• positive Coombs test
• thrombocytopenia
• leukopenia
• granulocytopenia
• anemia
• decreased hemoglobin
• decreased hematocrit
• hemolytic anemia

This medication should be stored in a tightly closed container that is well-ventilated, and the storage temperature should be maintained at room temperature between 1 and 30 degrees Celsius. Storing it this way helps maintain the effectiveness of the drug.

Appearance

White, elongated film-coated tablet

Package unit

50 tablets (10 tablets/PTP x 5)