Cephuroxime Axetil Tablet

Adult dose

For optimal absorption, take after meals. Adults and children aged 12 years and older Most infections: Administer 250mg twice daily. Severe lower respiratory tract infections, pneumonia, severe infections, or suspected infections caused by organisms with reduced susceptibility: Administer 500mg twice daily. Urinary tract infections: Administer 250mg twice daily. Uncomplicated gonorrhea: Administer 1g as a single dose. Lyme disease: Administer 500mg twice daily for 14 days (10~21 days). For treatment of infections caused by Streptococcus pyogenes (group A beta-hemolytic), this drug should be administered for 7~10 days. Patients with renal impairment: Creatinine clearance ≥ 30 mL/min/1.73m2, T1/2 (hours) 1.4 - 2.4: No dose adjustment required (standard dose: 125mg-500mg twice daily) Creatinine clearance 10 - 29 mL/min/1.73m2, T1/2 (hours) 4.6: Administer a standard single dose every 24 hours Creatinine clearance < 10 mL/min/1.73m2, T1/2 (hours) 16.8: Administer a standard single dose every 48 hours Patients receiving hemodialysis, T1/2 (hours) 2 - 4: Administer an additional standard single dose at the end of each dialysis session

Child dose

Infants and children under 12 years, most infections: Administer 125mg twice daily. Otitis media in children 2 years and older, severe infections: Administer 250mg twice daily. Infants and children under 12 years, Lyme disease: Administer 250mg twice daily for 14 days (10~21 days). Infants under 3 months: There is insufficient experience with use. Not suitable for treating patients, such as young infants and children, who cannot swallow tablets.

This medication is a cephalosporin antibiotic and should not be used in patients with a known allergy to cephalosporins. Patients with a history of hypersensitivity to penicillins or other beta-lactam antibiotics, patients with allergic disposition, patients with severe renal impairment, patients who have difficulty in oral intake, and the elderly should be administered with caution. This medication can cause various side effects such as candidiasis, blood abnormalities, skin rashes, headaches, dizziness, gastrointestinal disturbances, so symptoms should be closely monitored. Although rare, serious skin reactions, hepatitis, decreased renal function, and pseudomembranous colitis may occur; if any unusual symptoms occur, medical personnel should be notified immediately. To prevent the emergence of antibiotic-resistant bacteria, it is important to confirm the sensitivity of the infection-causing bacteria and use it for the necessary duration only. Shock symptoms or allergic reactions may occur during administration, so the patient’s condition should be meticulously observed and administration should be stopped immediately if any adverse effects appear. Like other antibiotics, there is a risk of disrupting intestinal flora, leading to candidiasis or Clostridium difficile infections, so caution is needed. This medication can cause dizziness; caution should be exercised when driving or operating machinery. Women who are pregnant or nursing should consult a physician before administering this medication and should use it cautiously only if necessary. Safety has not been established for infants under 3 months, and syrup formulations are recommended for children due to the bitter taste. In the elderly, due to decreased renal function and vitamin K deficiency leading to bleeding tendencies, dosage and intervals must be adjusted, and careful observation is necessary. This medication may affect blood and urine test results, so this should be considered during testing. In the case of overdose, symptoms such as seizures or encephalopathy may occur, and the drug concentration can be lowered through hemodialysis or peritoneal dialysis. This medication should be kept out of the reach of children and stored in its original container to prevent quality deterioration and misuse.

• Candida overgrowth
• eosinophilia
• positive Coombs test
• thrombocytopenia
• leukopenia
• granulocytopenia
• erythrocytopenia
• hemoglobin decrease
• hematocrit decrease
• hemolytic anemia

This medication should be stored in a tightly sealed container to prevent air from entering, and ideally kept at room temperature between 1 and 30 degrees Celsius. Storing this way helps maintain the medication's efficacy.

Appearance

White rectangular film-coated tablets

Package unit

50 tablets (10 tablets/PTP × 5)