Kedisolone Tablets (Methylprednisolone)

Adult use

1. The initial dose may vary from 4mg to 48mg per day as methylprednisolone, depending on the symptoms of the specific disease. In general, a low dose is sufficient for less severe conditions, but an initially high dose may be required in certain patients. The initial dose should be maintained or adjusted until a satisfactory response is obtained. If a satisfactory clinical result is not achieved after a reasonable period, discontinue administration and switch to another appropriate treatment. The dose should be determined individually according to the various diseases being treated and the patient's response. After an adequate response is achieved, an appropriate maintenance dose should be determined by reducing the initial dose at suitable intervals until the lowest dose that maintains an adequate clinical response is reached. Ongoing monitoring of the dose is required. Situations that may require dose adjustment include improvement or worsening of the disease, individual patient variability in drug response, and the effect on the patient of exposure to stressful circumstances that are not directly related to the symptoms of the disease being treated. In the latter case, it may be necessary to increase the dose for a period sufficient to achieve satisfactory control of the patient's condition. After long-term treatment, gradual dose reduction is recommended when discontinuing the drug. 2. Multiple sclerosis For the treatment of acute exacerbations of multiple sclerosis, it is effective to administer prednisolone 200mg daily for 1 week, followed by prednisolone 80mg every other day for 1 month (methylprednisolone 4mg is equivalent to prednisolone 5mg). 3. ADT (Alternate Day Therapy) Alternate-day therapy is a regimen in which twice the daily dose is administered on one morning every 2 days. Although a single morning dose causes considerably less adrenal suppression than taking prednisolone (10mg) in 4 divided doses every 6 hours, there is evidence that, when pharmacologic doses are used, a slight suppressive effect on adrenal activity continues into the following day. In addition, a single dose of any corticosteroid has been shown to suppress the adrenal cortex for 2 days or even longer. Methylprednisolone, hydrocortisone, prednisone, prednisolone, and other corticosteroids are considered short-acting (a single dose produces adrenal cortical suppression for 1¼ to 1½ days), and therefore alternate-day therapy is recommended. 3) ADT may initially be used for less severe diseases for which corticosteroid therapy is indicated. For more severe diseases, a regimen of high doses divided throughout the day will usually be required for initial control of disease progression. The initial suppressive dose should be continued until a satisfactory clinical response is achieved, usually for 4 to 10 days in many allergic and collagen diseases. ① Switch to ADT and gradually reduce the amount of corticosteroid given on alternate days. ② Reduce the daily dose of corticosteroid to the minimum effective dose as soon as possible, according to control of disease progression, and then switch to an alternate-day schedule. 4) Establishing ADT may be difficult and may not always be successful in these patients, since the HPA axis may already be suppressed. However, regular attempts to make the change are recommended. If this is difficult, administering 3 or even 4 times the daily dose on alternate days is preferable to simply doubling the daily dose. Once the patient is controlled again, attempt to reduce this dose to the minimum. 6) Maximum adrenal cortical activity occurs from 2 a.m. to 8 a.m., and minimum activity occurs from 4 p.m. to midnight. When administered during the period of maximum activity (in the morning), exogenous corticosteroids suppress adrenal cortical activity the least.

This medication should not be administered to certain patients. First, it should not be used in patients who have an allergy to this drug or any of its components. Additionally, it is not administered in cases of infections without appropriate antibiotics or systemic fungal infections, as the immunosuppressive effects of this drug can worsen the infection. Patients with herpes simplex, herpes zoster, or varicella should also not use this drug, nor should it be administered to those receiving live vaccines or attenuated live vaccines. This drug contains lactose and should not be used in patients with genetic conditions such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption. This drug should be used with caution in some patients. Patients with glaucoma may experience worsening symptoms due to increased intraocular pressure. Patients with tuberculosis disease or herpes simplex keratitis may also experience symptom worsening due to immunosuppression. Patients with posterior capsule cataract may have deteriorating symptoms due to effects on the lens. Patients with electrolyte disturbances or hypertension may have exacerbated symptoms due to electrolyte metabolic changes. Patients with thromboembolic disease may have worsened conditions due to increased blood coagulation. Recent surgical patients may experience delayed wound healing, and patients who have had an acute myocardial infarction may be at risk of cardiac rupture. Patients with diverticulitis or peptic ulcer may show worsening symptoms. Patients with psychiatric disorders may experience exacerbation of symptoms due to changes in neurotransmitters. Patients with severe osteoporosis may have worsening osteoporosis due to inhibition of bone formation. Patients with infections or diabetes mellitus may also see exacerbation of their conditions due to the effects of this medication. Patients with renal failure or congestive heart failure may have symptoms worsened due to sodium retention. Patients with hypothyroidism, fatty liver, fat embolism, myasthenia gravis, the elderly, epilepsy patients, and those with ulcerative colitis also require careful administration. When using this medication, various side effects may occur, so close monitoring is required. Fluid and electrolyte imbalances may lead to edema or hypertension. Effects on muscles and bones may result in myasthenia, osteoporosis, and fractures. Gastrointestinal issues may lead to nausea, vomiting, changes in appetite, ulcers, or pancreatitis. The skin may thin and have delayed wound healing, and rashes or hair loss may occur. In psychiatric and neurological aspects, symptoms such as headaches, insomnia, depression, or seizures may arise. The endocrine system may experience issues like Cushing's syndrome, growth suppression, or worsening diabetes. Eyes may develop glaucoma, cataracts, or infections, necessitating regular examinations. Immune system reactions or allergic responses should also be monitored carefully. This medication may cause adrenal insufficiency when used for extended periods, so it should not be stopped abruptly but tapered gradually. During trauma, surgery, or infection, the dosage may need to be temporarily increased. Due to immunosuppressive effects, individuals are particularly vulnerable to infections such as varicella and measles; thus, vaccination history should be checked, and exposure should be avoided. If an infection is suspected, immediate medical attention is required. In cases of active tuberculosis, appropriate anti-tuberculosis treatment should be administered alongside this medication, and latent tuberculosis patients should also be closely monitored. This medication may interact with various drugs, so caution is required when used in combination. Combining with drugs that can cause arrhythmias may lead to cardiac issues, and effects may be reduced when used with certain anticonvulsants or antibiotics. The risk of gastrointestinal bleeding increases when used with nonsteroidal anti-inflammatory drugs, and there may be changes in blood concentration when combined with aspirin. When used with anticoagulants or antidiabetic agents, dose adjustments are necessary. Caution should be taken when used with drugs affecting potassium levels. During pregnancy, this medication may harm the fetus and should be used only when absolutely necessary. During breastfeeding, it may transfer to breast milk, requiring the cessation of breastfeeding. In children, side effects such as growth retardation may occur, so the minimum effective dose should be used, and growth status should be closely monitored. In the elderly, there is a higher risk of side effects such as infection, osteoporosis, and hypertension, requiring careful administration and periodic monitoring. When using this medication, it is important to fully understand the cautions and side effects mentioned above, follow your doctor's instructions, and consult immediately if any abnormal symptoms occur.

Edema, sodium retention, potassium loss, fluid retention, hypokalemic alkalosis, congestive heart failure, hypertension, myasthenia, avascular necrosis of the femoral and humeral epiphyses, steroid myopathy, loss of muscle mass, pathological fractures of the ilium, osteoporosis, spinal compression fractures, arthralgia, tendon rupture, increased ALT, increased AST, increased ALP, nausea, thirst, vomiting, abdominal pain, loss of appetite, increased appetite, peptic ulcer, abdominal distension, pancreatitis, ulcerative esophagitis, diarrhea, delayed wound healing, facial erythema, thin and fragile skin, abnormal sweating, petechiae, purpura, suppressed skin reactions, purpura, acne, hirsutism, hair loss, pigmentation, papill edema, increased intracranial pressure, seizures, dizziness, headache, insomnia, euphoria, depression, Cushing's syndrome, menstrual irregularities, pediatric growth inhibition, symptoms of latent diabetes, secondary adrenal insufficiency, pituitary non-responsiveness, reduced glucose tolerance, increased requirements for insulin or oral hypoglycemic agents, suppression of adrenocorticotropic hormone secretion, increased intraocular pressure, glaucoma, posterior capsule opacification, secondary infections of the eye, retinal disorders, exophthalmos, negative nitrogen balance, immune system disorders, allergic reactions, shock, urticaria, anaphylactic reactions, hypersensitivity reactions

This medication may be sensitive to air and moisture, so it should be stored in a tightly closed container. It is best to maintain a storage temperature between 1 degrees and 30 degrees Celsius room temperature. Doing so will help preserve the medication's effectiveness safely for an extended period.

Appearance

White oval tablets

Package unit

30 tablets/bottle, 500 tablets/bottle