Dukra 375 mg tablet (Amoxicillin-Clavulanate Potassium (2:1))

Adult dose

For adults and children aged 12 years or older or weighing 40 kg or more, amoxicillin/clavulanate potassium is administered as a single dose of 250 mg/125 mg, taken orally three times a day at 8-hour intervals. In cases of severe and respiratory infections, the dose may be increased to 500 mg/125 mg per dose. In cases of renal impairment, the dosage should be adjusted according to the creatinine clearance rate, and for creatinine clearance rates of 10-30 mL/min, initial dosing should be between 250-

Child dose

For adults and children aged 12 years or older or weighing 40 kg or more, amoxicillin/clavulanate potassium is administered as a single dose of 250 mg/125 mg, taken orally three times a day at 8-hour intervals, especially for renal impairment.

This medication is a beta-lactam antibiotic and should not be administered to patients with allergies to penicillin or cephalosporin drugs. Particularly, patients with infectious mononucleosis or lymphocytic leukemia are at higher risk of rash so caution is needed. Patients who had past liver dysfunction or jaundice from this drug or penicillin group drugs should also avoid administration. Patients with poor liver function or severe kidney disease should be used cautiously as the drug concentration may increase. Caution should also be exercised in patients with allergic constitution or those who have difficulty absorbing the drug due to vomiting or diarrhea. This drug can cause various side effects including gastrointestinal symptoms, liver dysfunction, skin rash, hematological abnormalities, and neurological abnormalities. If symptoms occur, immediate consultation with a doctor is necessary. If severe diarrhea, abdominal pain, rash, or shortness of breath occur, the administration should be stopped immediately and treatment should be sought. It is important to administer this drug only for the necessary duration to prevent the development of resistant bacteria, and liver and kidney function as well as blood conditions should be regularly monitored during treatment. If there is a history of hypersensitivity to penicillin group drugs, anaphylactic shock may occur; therefore, the patient should be observed closely after administration. As this drug may interact with other medications, it is essential to inform the doctor or pharmacist about any medications currently being taken, especially when combined with anticoagulants or certain antibiotics. Women in early pregnancy or nursing should carefully consider the risks and benefits when administering this medication, and diarrhea or skin rash may appear in the baby during breastfeeding. It is not recommended for children under 12 years of age or weighing less than 40 kg. Elderly patients should use this medication cautiously, adjusting the dosage and administration intervals due to a decline in physical functions, increasing the risk of side effects. In case of overdose, gastrointestinal symptoms, kidney abnormalities, and neurological abnormalities may occur, so immediate medical care must be sought.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe allergic reactions, severe rash with high fever, blisters, peeling skin, oral/ocular mucosal pain, severe skin reaction, difficulty breathing or shortness of breath, asthma attacks, respiratory distress accompanied by cough and fever, jaundice (yellowing of skin or eyes), profound lethargy, liver abnormalities (jaundice), sudden and severe

Mild side effects

Diarrhea, pseudomembranous colitis, dyspepsia, stomatitis, gastritis, glossitis, nausea, vomiting, anorexia, abdominal pain, bloating, constipation, colonic discomfort, gastric acidity, soft stools, dry mouth, candidiasis, cholestatic jaundice, elevated AST, ALT, ALP, LDH, serum bilirubin, itching, erythema multiforme, stevens-johnson syndrome, toxic epidermal necrolysis, vesicular exfoliative dermatitis, acute generalized exanthematous pustulosis, eosinophilia, angioedema, serum sickness

This medication should be stored in a tightly sealed container to avoid moisture. It should also be kept in a dry place at a temperature below 25 degrees Celsius to maintain its effectiveness.

Appearance

White or almost white oval film-coated tablets

Package unit

100 tablets (10 tablets/PTP x 10)