Clarithromycin 500 mg

Adult dosage

Adults: The usual dose of clarithromycin is 250mg (potency) per dose, twice daily; for severe infections, administer 500mg (potency) per dose, twice daily. The usual treatment duration is 7～14 days. For patients with renal failure whose creatinine clearance is 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose twice daily. Do not administer to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this medicine per dose, twice daily. In this case, it should be administered concomitantly with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. Helicobacter pylori eradication in patients with duodenal ulcers: Administer this medicine 500mg (potency) 3 times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (Days 1–14), and omeprazole 40mg once daily for 28 days (Days 1–28).

Children's dosage

Pediatric patients aged 12 years and older: Same as adults For pediatric patients under 12 years of age, use clarithromycin dry syrup.

This medication should not be used in patients with allergies to certain ingredients. Patients who have experienced hypersensitivity to clarithromycin or similar class antibiotics should not be given this drug. Patients with certain heart conditions, especially those with arrhythmias, should be cautious as this medication may exacerbate heart problems. Patients with severely impaired liver or kidney function should use this medication cautiously as it can affect metabolism and excretion. Pregnant or breastfeeding women should avoid taking this medication. This drug may interact with many other medications, so it is essential to inform healthcare professionals if you are taking other drugs. If allergic symptoms, severe skin rash, or respiratory distress occur while taking this medication, stop use immediately and consult a healthcare professional. Long-term or high-dose use may result in auditory disturbances or tinnitus; report such symptoms. This medication may cause gastrointestinal disturbances, diarrhea, vomiting etc.; if symptoms are severe, it is advisable to inform healthcare professionals. Elderly patients or those with weakened immune systems are at a higher risk of side effects with this medication and should be more cautious. Dizziness or confusion may occur while driving or operating machinery during medication; caution is necessary. Overdosing may cause gastrointestinal disturbances or central nervous system symptoms, so the prescribed dosage must be strictly followed.

Shock, anaphylactic symptoms, difficulty breathing, seizures, flushing, rash, itching, hives, skin flushing, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disturbance, loss of appetite, constipation, discoloration of feces, pseudomembranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic pulmonary infiltrates, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychiatric disorders, depersonalization, trembling, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, increased serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, taste distortion, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, hypoglycemia, soft tissue infection, candidiasis, gastroenteritis, infection, vaginal infection, pseudomembranous colitis, impetigo, superficial soft tissue infection, erythema nodosum, leukopenia, neutropenia, thrombocytosis, eosinophilia, agranulocytosis, thrombocytopenia, anaphylactic reaction, hypersensitivity anaphylactic reaction, angioedema, loss of appetite, decreased appetite, hypoglycemia, insomnia, anxiety, nervous irritability, noise sensitivity, psychotic disorder, confused state, depersonalization, depression, disorientation, hallucinations, abnormal dreams, mania, taste disturbance, headache, loss of consciousness, dyskinesia, non-vestibular dizziness, drowsiness, tremors, seizures, loss of taste, abnormal olfaction, loss of smell, vestibular dizziness, hearing impairment, tinnitus, hearing loss, cardiac arrest, atrial fibrillation, QT prolongation on ECG, extrasystole, palpitations, vasodilation, asthma, nasal bleeding, pulmonary embolism, diarrhea, vomiting, dyspepsia, nausea, abdominal pain, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, stomatitis, glossitis, abdominal distension, constipation, thirst, belching, bloating, acute pancreatitis, tongue discoloration, tooth discoloration, abnormal liver function tests, cholestasis, hepatitis, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyltransferase, liver failure, hepatocellular jaundice, rash, hyperhidrosis, vesicular dermatitis, itching, hives, papular rash, acne, Henoch-Schonlein purpura, acute generalized exanthematous pustulosis, muscle spasms, musculoskeletal rigidity, myalgia, rhabdomyolysis, myopathy, increased blood creatinine, increased blood urea, renal failure, nephritis, injection site phlebitis, injection site pain, injection site inflammation, fatigue, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, urine discoloration, changes in mental status, obsessive behavior, hypokalemia, hypoxemia

This medication is sensitive to light, so it should be stored in a container that does not allow light to enter. It is advisable to maintain a storage temperature between 15 and 30 degrees Celsius to preserve the medication’s effectiveness.

Appearance

Yellow rectangular film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle