Gabastil Capsule 100mg (Gabapentin)

Adult dose

Epilepsy Monotherapy and adjunctive therapy in patients aged 13 years and older: To achieve a maintenance dose of 900 mg/day as gabapentin, titrate the dose gradually over the first 3 days of treatment as follows. Day 1: Administer one 300 mg capsule of this drug once daily or one 100 mg capsule of this drug 3 times daily (gabapentin 300 mg/day) Day 2: Administer one 300 mg capsule of this drug twice daily or two 100 mg capsules of this drug 3 times daily (gabapentin 600 mg/day) From Day 3: Administer one 300 mg capsule of this drug 3 times daily or three 100 mg capsules of this drug 3 times daily (gabapentin 900 mg/day) Alternatively, as an initial dose, one 300 mg capsule of this drug may be administered 3 times daily (gabapentin 900 mg/day). The dose may be increased to 1,200 mg/day as gabapentin, and the total daily dose must not exceed 2,400 mg as gabapentin. (There are insufficient data on the safety and efficacy of doses exceeding 2,400 mg/day as gabapentin.) The duration of treatment should be determined according to clinical need. Long-term treatment is generally required for epilepsy. If treatment with this drug is to be discontinued or if it is to be used in combination with another antiepileptic drug, the change should be made gradually over at least 1 week. Neuropathic pain (Neuropathic pain) Adults (18 years and older): To achieve a maintenance dose of 900 mg/day as gabapentin, titrate the dose gradually over the first 3 days of treatment as follows. Day 1: Administer one 300 mg capsule of this drug once daily or one 100 mg capsule of this drug 3 times daily (gabapentin 300 mg/day) Day 2: Administer one 300 mg capsule of this drug twice daily or two 100 mg capsules of this drug 3 times daily (gabapentin 600 mg/day) From Day 3: Administer one 300 mg capsule of this drug 3 times daily or three 100 mg capsules of this drug 3 times daily (gabapentin 900 mg/day) Alternatively, as an initial dose, one 300 mg capsule of this drug may be administered 3 times daily (gabapentin 900 mg/day). If necessary, the dose may be increased to 1,800 mg/day as gabapentin within one week, and the total daily dose must not exceed 3,600 mg as gabapentin. The total daily dose of this drug should be divided into 3 doses. The safety and efficacy of treatment for neuropathic pain for periods longer than 5 months have not been evaluated. Frail patients In frail patients with low body weight or patients who have undergone transplantation, the dose of this drug should be increased in 100 mg increments. Elderly patients Dose adjustment may be necessary due to age-related decline in renal function (see table). Patients with renal impairment (creatinine clearance of 80 mL/min or less) or patients receiving hemodialysis Dosage for patients with renal impairment: ≥80 mL/min: Total daily dose 900∼2,400 mg/day 50∼79 mL/min: Total daily dose 600∼1,800 mg/day 30∼49 mL/min: Total daily dose 300∼900 mg/day 15∼29 mL/min: Total daily dose 150b∼600 mg/day <15 mL/min: Total daily dose 150b∼300 mg/day a: The total daily dose should be divided into 3 doses. b: A dose of 3 × 100 mg should be administered every 2 days. In patients with creatinine clearance below 15 mL/min, the dose should be reduced in proportion to creatinine clearance. Dosage for patients receiving hemodialysis Initial dose: 300~400 mg of gabapentin is recommended. Maintenance dose: Administer 200~300 mg of gabapentin after 4 hours of hemodialysis; do not administer this drug on days when hemodialysis is not performed. Method and duration of administration This drug should be swallowed whole with sufficient fluid and may be taken with or without food. When administered 3 times daily, take care that the interval between doses does not exceed 12 hours to prevent recurrence of seizures. If a dose of this drug is missed (if more than 12 hours have elapsed since the last dose), the physician should decide whether an additional dose should be taken to make up for it. When used with antacids containing magnesium or aluminum, this drug should be administered at least 2 hours after the antacid. The duration of treatment with this drug should be determined according to clinical need. Any dose reduction, discontinuation, or switch to another alternative drug should be carried out gradually over at least 1 week (a longer period may be needed at the prescriber's discretion). To reduce the main adverse reactions, such as somnolence, dizziness, fatigue, and ataxia, the first dose on the first day of treatment should be taken at bedtime.

Child dose

Adjunctive therapy in children aged 3 years to 12 years: To achieve a maintenance dose of 30 mg/day of gabapentin per kg of body weight, titrate the dose over the first 3 days of treatment as follows. Day 1: administer 10 mg/kg body weight of gabapentin; Day 2: administer 20 mg/kg body weight of gabapentin; From Day 3: administer 30 mg/kg body weight of gabapentin. The dose may be increased, if needed, to a maximum of 40 mg per kg of body weight daily. The total daily dose of this medicine should be divided into 3 doses.

This medication may increase the risk of suicidal thoughts or behaviors, so if any symptoms of depression or mood changes occur during administration, consult a physician immediately. Abruptly discontinuing the medication may worsen seizures, so dosage should be gradually adjusted according to the physician's instructions. Some potential for tumor development has been reported in animal studies, but the effects on humans are not yet clear. Reports of sudden and unexpected deaths occurred during the use of this medication; however, these are within the normal range of risk for patients with epilepsy. If symptoms of pancreatitis (persistent abdominal pain, nausea, recurrent vomiting) occur, discontinue use immediately and inform a healthcare professional. Children aged 3 years to 12 years may exhibit central nervous system adverse reactions, so if emotional instability, aggression, impaired concentration, or hyperactivity occur, consult a healthcare professional. Combining this drug with CNS depressants, including narcotics, may cause severe drowsiness, respiratory depression, or coma, so it must be taken strictly under a physician's guidance. Patients with allergies to this drug or its components, acute pancreatitis, specific seizure types, or lactose intolerance should not take this medication. Patients with impaired kidney function, elderly patients, those with a history of psychiatric disorders, pregnant women or those who may become pregnant, and nursing mothers must consult a physician before use. Drowsiness or dizziness may occur, so caution is advised while driving or operating dangerous machinery. This medication can cause various side effects, including weight gain, vision changes, and skin rashes, so it is important to inform a healthcare professional of any abnormal symptoms. During pregnancy, it may affect the fetus, so if planning pregnancy or already pregnant, consult a physician before use, and use may be restricted while nursing. There may be interactions when using this drug with other medications or alcohol, so inform a healthcare professional of any medications being taken. This medication should be kept out of the reach of children and stored in its original container to prevent misuse.

• Suicidal impulses
• suicidal behavior
• depression
• abnormal changes in mood and behavior
• hemorrhagic pancreatitis
• emotional instability
• hostility
• thought disorder
• hyperactivity
• lethargy

This medication may be sensitive to air or moisture, so it should be stored in a sealed container. It is best to maintain the storage temperature between 1 to 30 degrees Celsius at room temperature to ensure the medication's effect remains safely over a long period.

Appearance

A hard capsule with white or light gray powder inside, with a white upper and lower part.

Package unit

Bottle packaging - 30 capsules/bottle, Bottle packaging - 300 capsules/bottle