Paintraju (Tramadol Hydrochloride)

Adult administration

Administer 50-100mg of tramadol hydrochloride intravenously or intramuscularly, and repeat every 4-5 hours as needed. The maximum daily dose is 400mg.

This medication may cause seizures if administered in excess of the recommended dose; therefore, it is essential to adhere to the prescribed dosage. Additionally, it should be used cautiously in patients with a risk of seizures or those with epilepsy, and it is important to administer it only when necessary. Prolonged use may lead to psychological and physical dependence, so it should only be used for a short period under strict supervision in patients at risk of drug abuse. Caution should be taken to avoid co-administration with alcohol or central nervous system depressants, as this may lead to severe drowsiness, respiratory depression, coma, or death. Particularly, patients who metabolize this drug rapidly due to genetic factors may have increased blood concentrations of active metabolites, heightening the risk of respiratory depression; therefore, dosage adjustments and monitoring are necessary. This medication should not be administered to children under 12 years old or to adolescents under 18 years old who have undergone tonsillectomy or adenoidectomy, and usage should be avoided in this age group when there is a high risk of respiratory depression. Injectable ampoules may contain glass fragments when the container is cut; therefore, special care should be taken when administering to children or the elderly. This drug should not be used in certain patient populations, such as those with acute alcohol intoxication, severe respiratory depression, head injuries, those taking MAO inhibitors, those with severe renal or hepatic impairment, pregnant or breastfeeding women, and those with certain allergic histories. Patients taking morphine, those with liver dysfunction, alcohol users, and those with a history of seizures should be administered this medication with caution, and dosage adjustments and close monitoring may be necessary. During treatment, symptoms such as drowsiness, dizziness, or nausea may occur, so it is advisable to avoid driving or operating dangerous machines. Additionally, prolonged use of this medication may lead to tolerance, necessitating increased dosages, and sudden discontinuation may trigger withdrawal symptoms, so dosage should be gradually reduced. In cases of overdose, severe respiratory depression and seizures may occur, so it is crucial to inform medical personnel immediately for appropriate emergency measures, and an antidote may be required. This medication may interact with various drugs; thus, if other medications are being taken, consultation with healthcare providers is essential before use. Pregnant or breastfeeding women should not use this medication, as serious side effects may occur in the infant, particularly while breastfeeding. In elderly patients, blood concentrations may increase, so the dosage must be restricted, and those over 75 years old should not exceed 300mg per day.

Serious side effects

Seizures, severe allergic reactions (shock, anaphylaxis, hives, bronchospasm, angioedema), respiratory depression, difficulty breathing, exacerbation of asthma, facial pallor, anaphylaxis, severe skin reactions (severe rash, Stevens-Johnson syndrome), cardiovascular abnormalities (palpitations, arrhythmias, elevated blood pressure, lowered blood pressure, syncope, orthostatic hypotension, tachycardia, bradycardia), liver abnormalities (increased liver enzymes), serious neurological symptoms (altered consciousness, hallucinations, confusion)

Mild side effects

• Drowsiness
• dizziness
• unsteadiness
• nausea
• vomiting
• abdominal distension
• flatulence
• abdominal pain
• loss of appetite
• constipation

This medication should be stored in a tightly sealed container to avoid contact with air and is best kept at room temperature between 1°C and 30°C. Storing it this way helps maintain the effectiveness of the drug.

Appearance

A clear, colorless, and odorless liquid in a colorless and transparent ampoule.

Package unit

1mL/ampoule x 50