Samsung Meropenem Injection 1 Gram (Meropenem Hydrate)

Adult administration

As meropenem hydrate, administer 0.5 to 1 g (potency) daily via intravenous infusion over 30 minutes 2 to 3 times a day. For suspected infections in patients with pathogenic pneumonia, peritonitis, or neutropenia, administer 1 g (potency) intravenously every 8 hours. For cystic fibrosis or meningitis, administer 2 g (potency) intravenously every 8 hours.

Child administration

In the case of bacterial meningitis in children 3 months and older, administer 40 mg per kg of body weight via intravenous infusion over 30 minutes every 8 hours, depending on the pathogen's sensitivity and the patient's condition, as well as the type of infection.

This drug should not be administered to patients who have experienced a severe allergic reaction to this drug, its components, or other carbapenem or beta-lactam antibiotics in the past. Patients taking valproate sodium should exercise caution when using this drug, as it may lower the serum concentration of valproate, increasing the risk of recurrent seizures. Individuals with allergic predispositions or those who easily exhibit allergic symptoms such as bronchial asthma or rashes should use this drug with caution. Patients with impaired kidney function may experience delayed excretion of this drug, leading to central nervous system side effects; thus, dosage adjustment or increased intervals between doses may be necessary. Patients with epilepsy or central nervous system disorders may be predisposed to symptoms such as seizures or consciousness alterations and should be administered this drug with caution. Patients with severe liver impairment should be cautious using this drug due to the risk of worsening liver function. Elderly patients may be at higher risk of side effects due to decreased bodily functions and may develop bleeding tendencies associated with vitamin K deficiency, requiring caution. Use in infants, particularly those under 3 months of age, is not recommended as safety and efficacy have not been established. During administration, severe allergic reactions such as shock or anaphylaxis may rarely occur, thus patients should be monitored adequately. If hypersensitivity reactions such as skin rash, hives, or itching occur, administration should be stopped immediately, and appropriate treatment should be sought. Regular checks and observation are needed as side effects like blood abnormalities, liver function impairments, and kidney function impairments may occur. If severe diarrhea symptoms such as membrane enteritis occur, immediate discontinuation of administration and treatment are necessary. If central nervous system symptoms like seizures or consciousness disturbances occur, administration should be stopped immediately. Should symptoms of respiratory complications or severe skin reactions occur, administration should cease and appropriate measures should be taken. This drug should avoid prolonged or unnecessary use, administering only for the minimum duration necessary to prevent the emergence of resistant bacteria. Sensitivity tests should be performed before and during administration to confirm effectiveness, and other medications should be considered as needed. Due to the potential for shock occurrence, thorough interviews and skin reaction tests should be conducted in advance, and emergency measures should be prepared. Caution is needed for drug interactions with other medications, especially when used concurrently with valproate, antiepileptic drugs, hormonal contraceptives, and warfarin. Women who are pregnant or may become pregnant should carefully consider the benefits and risks if administration of this drug is necessary. Nursing mothers should avoid breastfeeding, as this drug may be excreted in breast milk. This drug is to be administered only via intravenous injection; it should be used as soon as possible after dissolution, and time and temperature should be strictly adhered to during storage. Caution is warranted when driving or operating machinery, as side effects such as headaches, dizziness, and mental confusion may occur.

Serious side effects

Shock, anaphylactic reaction, urticaria, severe swelling (edema), chest discomfort, shortness of breath, rash, toxic epidermal necrolysis (Lyell syndrome), Stevens-Johnson syndrome, eosinophilia accompanied by systemic symptoms (DRESS syndrome), erythema multiforme, acute generalized exanthematous pustulosis (AGEP), fulminant hepatitis, liver failure, jaundice, acute renal failure, acute colitis, asthma, increased coughing, respiratory.

Mild side effects

• Oral dysgeusia
• dizziness
• changes in bowel movements
• tinnitus
• sweating
• a feeling of warmth
• erythema
• itching
• fever
• redness

This drug should be stored in a sealed container to prevent exposure to air or moisture and is best kept at room temperature between 1 and 30 degrees Celsius. Proper storage helps maintain the drug's effectiveness over time.

Appearance

A crystalline powder ranging from white to light yellow in a colorless, transparent vial.

Package unit

10 vials/box