Levofl Injection (Levofloxacin Hydrate)

Adult administration

Administered as a drip intravenous injection once or twice a day. The dosage is determined according to the type and severity of the infection and the susceptibility of the causative organism. Generally, after the first few days of intravenous administration, it can be switched to oral form, and the oral dosage is the same as the intravenous dosage. The administration method is via drip infusion intravenously once or twice a day for a maximum of 14 days, and the infusion time should take at least 60 minutes.

As a fluoroquinolone antibiotic, this drug can cause serious side effects such as tendonitis or tendon rupture, peripheral neuropathy, central nervous system disorders, and exacerbation of severe myasthenia gravis. If any of these symptoms occur, the use of this drug should be discontinued immediately, and it should not be administered to patients with a history of severe myasthenia gravis. This drug is only used for specific acute bacterial infections and should only be utilized when there are no other treatment options available. The injection should be administered slowly over a period of time, and if blood pressure drops suddenly during the infusion, the infusion must be stopped immediately. Caution should be taken to avoid concurrent use with corticosteroids due to an increased risk of tendon rupture. If symptoms of tendonitis or tendon rupture occur, activities should be avoided, and rest should be taken. Seizures or central nervous system disorders may develop; therefore, careful administration is required for patients with a history of epilepsy or central nervous system diseases. This drug may cause various adverse reactions such as hypersensitivity reactions, skin rashes, gastrointestinal disturbances, neurological disorders, cardiac disturbances, musculoskeletal disorders, liver and kidney function abnormalities, and hematological disorders. Especially when serious skin reactions or blood anomalies occur, immediate notification to medical personnel is crucial. Photosensitivity reactions may occur; therefore, strong sunlight or UV exposure should be avoided, and if dizziness or drowsiness occurs, driving or operating machinery should be refrained from. To prevent the development of resistant bacteria, it should be administered for the minimum necessary duration, and adequate fluid intake is essential. Diabetic patients should closely monitor blood sugar fluctuations, and this drug should not be used in pregnant or breastfeeding women, adolescents under 18 years of age, or those with hypersensitivity. Elderly patients may require dose adjustments due to impaired kidney function, and special caution is needed for patients with aneurysms or heart valve diseases. Overdosing may lead to central nervous system symptoms and cardiac disturbances; hence, immediate appropriate treatment and observation are necessary. This medication should only be mixed with specific solutions and used promptly after opening. Additionally, it should not be administered simultaneously with solutions containing metal ions.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, paleness, severe allergic reactions, severe rashes with high fever, blisters, skin peeling, pain in oral/ocular mucosa, severe skin adverse reactions, asthma attacks, respiratory abnormalities accompanied by cough and fever, breathing difficulties, yellowing of skin or eyes (jaundice), extreme lethargy, liver abnormalities (jaundice), sudden and severe headache, lightning headache.

Mild side effects

• Itching
• rash
• nausea
• diarrhea
• loss of appetite
• vomiting
• abdominal pain
• dyspepsia
• abdominal bloating
• constipation

This drug should be stored in a sealed container that is protected from air and light, avoiding direct sunlight and storing at room temperature between 1 degree and 30 degrees Celsius.

Appearance

A clear yellowish liquid with a faint green tint in a colorless transparent vial injection.

Package unit

100mL/vial × 1 vial