Clarithromycin 250 mg Tablets

Adult dosage

○ Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual treatment period is 7～14 days. In patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be reduced by half. That is, administer 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer for more than 14 days in these patients. ○ Mycobacterial infections: Administer 500mg (potency) twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, or rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) 3 times daily for 14 days in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

○ Children 12 years of age and older: Same as adults ○ Children under 12 years of age: Use clarithromycin dry syrup.

This medication should not be used in patients with allergies to specific components. Patients with a history of hypersensitivity to macrolide antibiotics should also avoid it. Patients taking medications related to heart rhythms may be at risk for cardiac arrhythmias and should not use this medication concurrently. Patients with severely impaired liver or kidney function may experience issues with metabolism and excretion of this drug, thus it should be administered cautiously or avoided. It is recommended that pregnant or nursing women do not take this medication. This medication should not be used for patients with central nervous system infections. Caution is necessary as serious side effects may arise from drug interactions when used with specific medications. This medication contains lactose and should not be given to patients with lactose intolerance. Older adults or patients with heart diseases should use this medication cautiously due to a higher risk of side effects. If any allergic reactions or cardiac symptoms appear while taking this medication, discontinue use immediately and consult a physician. This medication can cause various side effects, including gastrointestinal disturbances, skin rashes, liver dysfunction, kidney dysfunction, and central nervous system issues, so patients should inform healthcare providers of any symptoms. Prolonged or high-dose usage may lead to hearing loss or tinnitus, requiring caution. When using this medication with other drugs, it is advisable to consult a specialist as drug concentration may change due to interactions. If persistent diarrhea or abdominal pain occurs while taking this medication, it may indicate a serious condition such as pseudomembranous colitis, requiring immediate medical attention. Pregnant or lactating women should avoid this medication, and if absolutely necessary, breastfeeding should be discontinued. Pediatric patients or those with severely impaired kidney function may require dosage adjustments, as safety for children under 12 has not been adequately established. In the case of an overdose, gastrointestinal symptoms and central nervous system issues may occur, necessitating immediate medical treatment. Caution is also advised during driving or operating machinery, as dizziness or confusion may occur. When using this medication, to prevent the development of resistant bacteria, it should be taken only for the required duration and not stopped or adjusted arbitrarily.

Shock, anaphylactic symptoms, difficulty breathing, convulsions, flushing, rash, itching, hives, skin flushing, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, indigestion, abdominal pain, discomfort, gas retention, diarrhea, oral mucosal erosion, upper abdominal pain, dry mouth, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, loss of appetite, constipation, discoloration of stool, pseudomembranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltrates, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, orientation disturbance, hallucinations, psychosis, derealization, tremor, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, elevated LDH, increased ALP, elevated total bilirubin, increased serum creatinine, elevated BUN, interstitial nephritis, kidney failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, ventricular fibrillation, malaise, headache, dysgeusia, hearing loss, paresthesia, arthralgia, myalgia, olfactory disturbance, hypoglycemia, purpuric rash, acute generalized exanthematous pustulosis (AGEP), muscle cramps, musculoskeletal rigidity, myopathy, elevated blood urea, venous thrombophlebitis at injection site, pain at injection site, inflammation at injection site, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, increased serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color, cardiac arrest, atrial fibrillation, ectopic beats, palpitations, vasodilation, asthma, nosebleed, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, teeth discoloration, rash, diaphoresis, vesicular dermatitis, papulovesicular rash, acne, Henoch-Schonlein purpura, angioedema, anaphylactic reaction

This medication is sensitive to light and should be stored in a tightly sealed container that protects it from light exposure. Additionally, it is best stored at room temperature between 15°C and 30°C. Proper storage will help maintain its effectiveness and safety.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 200 tablets/bottle