Clarithromycin Tablets 500 mg

Adult dosage

○ Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7～14 days. In patients with renal failure and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer this medication to such patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) of this medication twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medication 3 times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for an additional 14 days. That is, administer clarithromycin 500mg (potency) 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

○ Children aged 12 years and older: same as adults. For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be used in patients with allergies to specific additives or in those who have had hypersensitivity reactions to similar classes of antibiotics. Additionally, it is not safe to administer to patients with a history of cardiovascular disease or prolonged QT interval, or in those with severe liver or kidney dysfunction. It is not recommended for use in pregnant or nursing women. This medication may interact with various other drugs; therefore, it is essential to inform healthcare providers about any medications currently being taken. During administration, if any abnormal symptoms such as allergic reactions, gastrointestinal symptoms, skin rashes, or breathing difficulties occur, immediate consultation with a physician is required. Caution should be taken as elderly patients or those with reduced liver or kidney function may require dose adjustments. Long-term or excessive use may lead to side effects like hearing loss, tinnitus, and myalgia, thus adherence to prescribed dosages and administration is crucial. This medication contains lactose, so patients with lactose intolerance should avoid taking it, and if gastrointestinal disturbances like diarrhea or abdominal pain occur after administration, they should consult healthcare providers. Finally, during the use of this medication, caution is advised as dizziness or decreased concentration may occur while driving or operating machinery.

shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, itching, urticaria, skin erythema, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient teeth discoloration, pancreatitis, increased amylase, dysgeusia, anorexia, constipation, fecal discoloration, membrane colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltrate, interstitial pneumonia, chronic bronchitis, exacerbation of acute maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucination, psychosis, depersonalization, tremors, paresthesia, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, injection site phlebitis, injection site pain, injection site inflammation, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, increased serum alkaline phosphatase, increased serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, urine color abnormality

This medication is sensitive to light, so it should be stored in a tightly sealed container that protects from light exposure. Additionally, to maintain the efficacy of the drug, it is recommended to store it at room temperature between 15°C and 30°C.

Appearance

Yellow oval film-coated tablets

Package unit

30 tablets/bottle, 200 tablets/bottle