Q-Pam XR Extended-Release Tablet 500 mg (Levetiracetam)

Adult dose

Because this medicine is an extended-release tablet, swallow it whole without crushing, splitting, or chewing. This medicine may be taken with or without food, with plenty of water. Take the daily dose once daily. Monotherapy and adjunctive therapy for partial-onset seizures (12 years and older) Adults (18 years and older): Start this medicine at 1,000mg once daily. Depending on clinical response and tolerability, the dose may be increased or decreased by 1,000mg once daily every 2 weeks. The maximum recommended dose is 3,000mg per day. Patients with renal impairment: Because levetiracetam clearance is related to renal function, administer the dose individually according to the patient's renal function. Dose adjustment in adults with renal impairment Normal, creatinine clearance ≧ 80 (mL/min/1.73m2): Single dose 1,000-3,000mg, once daily (24-hour interval) Mild, creatinine clearance 50-79 (mL/min/1.73m2): Single dose 1,000-2,000mg, once daily (24-hour interval) Moderate, creatinine clearance 30-49 (mL/min/1.73m2): Single dose 500-1,500mg, once daily (24-hour interval) Severe, creatinine clearance < 30 (mL/min/1.73m2): Single dose 500-1,000mg, once daily (24-hour interval) Patients with hepatic impairment: No dose adjustment is necessary in patients with mild to moderate hepatic impairment. In patients with severe hepatic impairment, creatinine clearance may underestimate renal impairment. Therefore, when creatinine clearance is less than 60mL/min/1.73m2, reducing the daily maintenance dose by 50% is recommended. Older adults (65 years and older): Dose adjustment is recommended in older patients with impaired renal function.

Child dose

Adolescents weighing 50kg or more (12~17 years): Start this medicine at 1,000mg once daily. Depending on clinical response and tolerability, the dose may be increased or decreased by 1,000mg once daily every 2 weeks. The maximum recommended dose is 3,000mg per day.

This drug is used to treat epilepsy and there is a risk of mental health issues such as suicidal thoughts, suicidal behavior, and depression during treatment. Therefore, patients and caregivers should immediately inform healthcare professionals if these symptoms occur. This medication may cause central nervous system side effects such as drowsiness, fatigue, coordination problems, and behavioral changes when initially taken or when dosage adjustments are made. Abruptly stopping the medication may lead to worsening seizures, so it should be gradually reduced under a doctor's instruction. Patients should avoid this drug if allergic to any of its components, and dose adjustment may be necessary for patients with impaired kidney function. There can also be side effects such as decreased blood cell counts, so blood tests should be conducted if fever or infection symptoms arise. The medication may also induce psychiatric symptoms, such as irritability, aggression, anxiety, and depression, and medical consultation is warranted if such symptoms appear. Patients with heart diseases or electrolyte imbalances should be cautious due to the risk of QT interval prolongation on ECG. Pregnant women or those planning pregnancy should consult healthcare professionals about the use of this drug, and breastfeeding mothers are advised to avoid breastfeeding. The safety in children and the elderly has not been well established, so it should be used with caution. Symptoms such as drowsiness or dizziness may appear when driving or operating machinery, so caution is advised. In case of overdose, symptoms such as drowsiness, decreased consciousness, or respiratory depression may occur, requiring immediate emergency treatment. Although this drug has low interaction potential with other medications, caution is required when combined with certain medications, so current medications should be disclosed to healthcare professionals. Finally, this medication should be kept out of reach of children, and it is safer not to change the container.

• Suicidal impulses
• suicidal behavior
• depression
• abnormal changes in mood and behavior
• drowsiness
• fatigue
• coordination motor disorder
• behavioral abnormalities
• asthenia
• irritability

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. Additionally, it should be protected from extreme heat or cold, and stored at room temperature between 1°C and 30°C.

Appearance

White, rectangular extended-release film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle