Tobramycin Injection 80mg (Tobramycin)

Adult administration

For severe infections, administer 3mg (potency) per kg body weight per day, divided into 3 doses via intravenous or intramuscular injection. In life-threatening infections, doses may be increased up to 5mg (potency) per kg body weight per day, divided into 3 to 4 doses. Upon symptom improvement, reduce to 3mg (potency) per kg body weight per day. Do not exceed 5mg (potency) per kg body weight per day without serum concentration measurement.

Child administration

Administer 6 to 7.5mg (potency) per kg body weight per day, divided into 3 to 4 doses via intravenous or intramuscular injection. For neonates (less than 1 week old): administer 4mg (potency) per kg body weight per day, divided and given every 12 hours.

This medication may allow glass particles to enter when the injection container is opened; therefore, care must be taken not to introduce any glass particles. Extra caution is necessary for children and the elderly. This drug should not be administered to patients with known allergies to it, patients with specific ear diseases, severe renal impairment, those who are pregnant or nursing, patients with muscular disorders, patients with asthma, and patients with neurological disorders. Patients with reduced kidney or liver function, newborns or premature infants, the elderly, and those with poor nutritional status should be particularly cautious when using this medication, and any signs of an allergic reaction should be closely monitored. Rarely, using this medication may result in shock, indigestion, blood abnormalities, dizziness, tinnitus, hearing loss, liver dysfunction, kidney damage, skin rash, allergic reactions, vitamin deficiency symptoms, and injection site pain. If any unusual symptoms occur, use should be immediately discontinued, and medical attention should be sought. To prevent the emergence of resistant strains, it is important to confirm susceptibility to the infecting bacteria and use this medication for the minimum required duration. To prevent hearing impairment and deterioration of kidney function, it is advisable to limit the duration of administration to 10 days. Regularly monitoring blood drug concentrations is crucial to ensure levels do not become excessively high or low, especially in patients with compromised renal function, the elderly, or those on prolonged treatment. Patients with specific genetic mutations may have an increased risk of permanent hearing loss from this medication, and alternative treatments may need to be considered in such cases. This medication should not be used with other drugs that place strain on the kidneys, and caution is needed when used concurrently with anesthetics or muscle relaxants due to the risk of respiratory depression. During pregnancy, it may cause hearing damage to the fetus, so administration should only occur when absolutely necessary, whereas breastfeeding mothers should discontinue breastfeeding while taking this medication as it can be passed into breast milk. Newborns or low birth weight infants have immature renal function potentially leading to prolonged drug retention in the body, necessitating careful adjustment of dosing intervals. The elderly are at a higher risk of drug accumulation due to decreased renal function, which may lead to side effects, requiring adjustment of dosage and monitoring of their status. In the event of overdose, kidney damage, hearing and vestibular dysfunction, muscle paralysis, and respiratory failure may occur, requiring immediate hospital treatment such as hemodialysis. This medication's efficacy may diminish if mixed with beta-lactam antibiotics; accordingly, they should be administered through different routes. Caution is warranted when administering this medication to patients who have undergone massive blood transfusions, as it may result in neuromuscular blockade and respiratory paralysis. Lastly, some bacteria resistant to this medication have been reported, so usage should be in accordance with medical personnel's directions.

Serious side effects

Hives, severe swelling (edema), severe allergic reactions, shock, severe renal failure, acute renal failure, jaundice, serious skin adverse reactions (exfoliative dermatitis, toxic epidermal necrolysis, erythema multiforme, Stevens-Johnson syndrome), asthma attacks, respiratory depression, eighth cranial nerve disorders (including dizziness, tinnitus, hearing loss), severe edema, seizures, confusion, paralysis, severe headache, severe edema, or urination abnormalities

Mild side effects

• Nausea
• vomiting
• loss of appetite
• stomatitis
• diarrhea
• anemia
• leukopenia
• leukocytosis
• granulocytosis
• eosinophilia

To protect this medication from air and moisture, it should be stored in a sealed container at a temperature between 1 degree and 30 degrees Celsius. Proper storage can help maintain the efficacy of the medication over time.

Appearance

A colorless to pale yellow transparent liquid contained in a colorless transparent ampoule

Package unit

2mL-50 ampoules per box