Certirol Tablet 0.75 mg (Everolimus)

Adult dosage

Kidney and heart transplant patients: As soon as possible after transplantation, administer an initial dose of 0.75mg orally twice daily (total daily dose 1.5mg). Liver transplant patients: At approximately 4 weeks after transplantation, administer an initial dose of 1.0mg orally twice daily (total daily dose 2.0mg). The total daily dose of this medication should always be administered consistently either with food or on an empty stomach, divided into 2 doses per day, and used in combination with cyclosporine or tacrolimus in microemulsion formulation. For oral use only. Swallow whole with water; do not crush before administration. Dose adjustments are made at intervals of 4-5 days according to the patient's blood levels, tolerability, individual response, changes in concomitant medications, and clinical status. The dose should be reduced in patients with hepatic impairment: to approximately 2/3 of the usual dose in mild impairment (Child-Pugh A), approximately 1/2 in moderate impairment (Child-Pugh B), and approximately 1/3 in severe impairment (Child-Pugh C).

Children's dosage

Pediatric patients under 18 years of age: The safety and efficacy of this medication have not been established in children under 18 years of age.

This drug is an immunosuppressive agent, so caution is especially needed when using it in combination with other immunosuppressants. The risk of acute rejection may increase if not used with calcineurin inhibitors, so follow the doctor's instructions carefully. Care should be taken when using this drug in conjunction with certain antibody treatments such as thymoglobulin, as it may increase the risk of infections. The immune function is suppressed, increasing the risk of various infections, including bacteria, viruses, and fungi, so if any symptoms of infection appear, immediate consultation with a healthcare professional is necessary. Medications that affect CYP3A4, the enzyme that metabolizes this drug in the liver, may alter drug concentrations, so interactions should be carefully monitored. This medication may increase the risk of malignant tumors such as lymphoma or skin cancer; therefore, it is essential to protect the skin from UV rays and undergo regular check-ups. Side effects such as angioedema have been reported when taken with ACE inhibitors, so extreme caution is warranted. It might affect kidney function, so regular kidney function tests are needed, and more caution should be taken when combined with other nephrotoxic drugs. Proteinuria may occur, so urine tests should check protein levels, and if proteinuria worsens, consult a physician. There is an increased risk of thrombosis within the first 30 days after kidney transplantation, so symptoms should be closely monitored. Delayed wound healing or increased risk of infection may occur after surgery, so the use of this drug should be discussed with the doctor before and after the procedure. Blood-related abnormalities, such as anemia and leukopenia, may occur, requiring regular blood tests. Serious lung diseases, such as interstitial lung disease or non-infectious pneumonia, may occur, so immediate medical attention should be sought if there are symptoms like shortness of breath or cough. This medication contains lactose, so patients with lactose intolerance should not take it. It may pose risks to the fetus during pregnancy, so it should be avoided in pregnant women or those planning to become pregnant, and breastfeeding women should also avoid its use. For men, this drug may cause temporary infertility, so effective contraceptive methods should be used during treatment and for a certain period after discontinuation. In cases of overdose, there is no specific antidote, so one should seek immediate medical attention for appropriate treatment. This medication must be taken whole and should not be crushed or divided. There is no clear information regarding its effects on driving or operating machinery, so caution is advised.

• Infection
• pneumonia
• upper respiratory tract infection
• urinary tract infection
• sepsis
• wound infection
• malignant tumor
• skin malignant tumor
• lymphoma
• anemia

This medication should be stored in a tightly sealed container to protect it from air and moisture, and it should be kept away from direct sunlight in a cool place (below 30 degrees). This ensures that the medication's effectiveness is maintained for a longer period.

Appearance

White to yellowish round tablets

Package unit

60 tablets (10 tablets/PTP X 6)